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Volumn 13, Issue 14, 2003, Pages 2297-2302

Heterocyclic thrombin inhibitors. Part 2: Quinoxalinone derivatives as novel, potent antithrombotic agents

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 10A INHIBITOR; QUINOXALINE DERIVATIVE; THROMBIN INHIBITOR;

EID: 0038004032     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00443-8     Document Type: Article
Times cited : (91)

References (24)
  • 3
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    • Greenlee, W., Ed.; Academic Press: San Diego, New York, Boston, London, Sydney, Tokyo, Toronto
    • (c) Fevig, J. M., Wexler, R. R., In Annual Reports in Medicinal Chemistry; Greenlee, W., Ed.; Academic Press: San Diego, New York, Boston, London, Sydney, Tokyo, Toronto 1999, Vol. 34, p81.
    • (1999) Annual Reports in Medicinal Chemistry , vol.34 , pp. 81
    • Fevig, J.M.1    Wexler, R.R.2
  • 10
    • 85031150612 scopus 로고    scopus 로고
    • note
    • 2, R factor 18.9%, R free 21.1%.
  • 11
    • 85031148596 scopus 로고    scopus 로고
    • note
    • 13 using MMFF94 charges. During the calculations the factor Xa binding site remained flexible in order to allow possible induced fits. The factor Xa binding site was defined by including residues within a sphere of 7 Å radius around 17 in its trypsin bound position.
  • 19
    • 11944251068 scopus 로고
    • Maximally diagonal force constants in dependent angle-bending coordinates. Implications for the design of empirical foerce fields
    • (a) Halgren T. Maximally diagonal force constants in dependent angle-bending coordinates. Implications for the design of empirical foerce fields. J. Am. Chem. Soc. 112:1990;4710.
    • (1990) J. Am. Chem. Soc. , vol.112 , pp. 4710
    • Halgren, T.1
  • 20
    • 5544242529 scopus 로고    scopus 로고
    • MMFF VI, MMFF94s option for energy minimization studies
    • (b) Halgern T. MMFF VI, MMFF94s option for energy minimization studies. J. Comp. Chem. 20:1999;720.
    • (1999) J. Comp. Chem. , vol.20 , pp. 720
    • Halgern, T.1
  • 23
    • 85031161463 scopus 로고
    • PhD. Thesis; TU Muenchen: Muenchen
    • Turk D. PhD. Thesis. 1992;TU Muenchen: Muenchen.
    • (1992)
    • Turk, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.