Effector protease receptor 1 mediates the mitogenic activity of factor Xa for vascular smooth muscle cells in vitro and in vivo

Journal of Clinical Investigation

Volumn 101, Issue 5, 1998, Pages 993-1000

  Herbert, J M ^a   Bono, F ^a   Herault J P ^a   Avril, C ^a   Dol, F ^a   Mares, A M ^a   Schaeffer, P ^a  

^a SANOFI   (France)

Author keywords

Effector cell protease receptor 1; Factor Xa; Myointimal; Restenosis; Smooth muscle cells

Indexed keywords

2 [4 [(1 ACETIMIDOYL 3 PYRROLIDINYL)OXY]PHENYL] 3 (7 AMIDINO 2 NAPHTHYL)PROPIONIC ACID; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 10A; EFFECTOR CELL PROTEASE RECEPTOR 1; RECEPTOR; THROMBIN; UNCLASSIFIED DRUG;

ANIMAL CELL; AORTA; ARTERY INTIMA PROLIFERATION; ARTICLE; CAROTID ARTERY; CONTROLLED STUDY; HUMAN; HUMAN CELL; MALE; MITOGENESIS; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; RABBIT; VASCULAR SMOOTH MUSCLE;

EID: 0032030842     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1833     Document Type: Article

References (35)

1. Gasic, G.P., C.P. Arenas, T.B. Gasic, and G.J. Gasic, 1992. Coagulation factors X, Xa, and protein S as potent mitogens of cultured aortic smooth cells. Proc. Natl. Acad. Sci. USA. 89:2317-2320.
2. Ko, F.N., Y.C. Yang, S.C. Huang, and J.T. Ou. 1996. Coagulation factor Xa stimulates platelet-derived growth factor release and mitogenesis in cultured vascular smooth muscle cells of rats. J. Clin, Invest. 98:1493-1501.
3. Ragosta, M., L.W. Gimple, S.D. Gertz, CT. Dunwiddie, G.P. Vlasuk, E.R. Powers, W.C. Roberts, and I.J. Sarembock. 1994. Specific factor Xa inhibition reduces restenosis after balloon angioplasty of atherosclerotic femoral arteries in rabbits. Circulation. 89:1262-1271.
4. Altieri, D.C., and T.S. Edgington. 1990. Identification of effector cell protease receptor-1: a leukocyte-distributed receptor for the serine protease factor Xa. J. Immunol. 145:246-253.
5. Nicholson, A.C., R.L. Nachman, D.C. Altieri, B.D. Summers, W. Ruf, T.S. Edgington, and D.P. Hajjar. 1996. Effector cell protease receptor-1 is a vascular receptor for coagulation factor Xa. J. biol. Chem. 271:28407-28413.
6. Bono, F., J.P. Herault, C. Avril, P. Schaeffer, and J.M. Herbert. 1997. Human umbilical vein endothelial cells express high affinity receptors for factor Xa. J. Cell. Physiol. 172:36-43.
7. Hara, T., S. Kunitada, and M. Iwamoto. 1993. DX-9065a, a synthetic and selective factor Xa inhibitor: species difference in its anticoagulant activity. Thromb. Haemost. 69:890-896.
8. Lormeau, J.C., J.P. Hérault, C. Gaich, T. Barzu, T.G. van Dinther, A. Visser, and J.M. Herbert. 1997. Determination of the anti-factor Xa activity of the synthetic pentasaccharide SR 90107A/Org 31540 and of two structural analogues. Thromb, Res. 85:67-75.
9. Schaeffer, P., A.M. Mares, F. Dol, F. Bono, and J.M. Herbert. 1997. Coagulation factor Xa induces endothelium-dependent relaxations in rat aorta. Circ. Res. 81:824-828.
10. 88 in factor Xa mediates ligand binding to effector cell protease receptor-1. J. Biol. Chem. 272:8340-8345.
11. Munson, P.J., and D. Rodbard. 1980. Ligand: a versatile computerized approach for characterization of ligand-binding systems. Anal. Biochem. 107: 220-239.
12. Berridge, M., C. Dawson, C. Downes, C. Heslop, and R. Irvine. 1983. Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides. Biochem. J. 212:473-482.
13. Herbert, J.M., A. Tissinier, G. Defreyn, and J.M. Maffrand. 1993. Inhibitory effect of clopidogrel on platelet adhesion and intimai proliferation after arterial injury in rabbits. Arterioscler. Thromb. 13:1171-1179.
14. Davie, E.W., K. Fujikawa, and W. Kisiel. 1991. The coagulation cascade: initiation maintenance and regulation. Biochemistry. 30:10363-10370.
15. Daniel, T.O., V.C. Gibbs, D.F. Milfay, M.R. Garovoy, and L.T. Williams. 1986. Thrombin stimulates c-sis gene expression in microvascular endothelial cells. J. Biol. Chem. 261:9579-9582.
16. Coughlin, S. 1993. Thrombin receptor structure and function. Thromb. Haemostasis. 70:184-187.
17. Stitt, T.N., G. Conn, M. Gore, C. Lai, J. Bruno, J. Fisher, J. Gies, P.F. Jones, T.E. Ryan, D.H. Chen, et al. 1995. The anticoagulation factor protein S and its relative, GAS6, are ligands for the Tyro 3/AXL family of receptor tyrosine kinases. Cell. 80:661-670.
18. Ross, R. 1993. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 362:801-809.
19. Kook, Y.H., J. Adamshi, A. Zelent, and L. Ossowski. 1994. The effect of antisense inhibition of urokinase receptor in human squamous cell carcinoma on malignancy. EMBO (Eur. Mol. Biol. Organ.) J. 13:3983-3991.
20. Tracy, P.B., M.E. Nesheim, and K.G. Mann. 1992. Platelet factor Xa receptor. Methods Enzymol. 215:329-360.
21. Bouchard, B.A., C.S. Catcher, B.R. Thrash, C. Adida, and P.B. Tracy. 1997. Effector cell protease receptor-1, a platelet activation-dependent membrane protein, regulates prothrombinase-catalyzed thrombin generation. J. Biol. Chem. 272:9244-9251.
22. Rodgers, G.M., and M.A. Shuman, 1985. Characterization of the interaction between factor Xa and bovine aortic endothelial cells. Biochim. Biophys. Acta. 844:320-329.
23. McGee, M.P., and H. Rothberger. 1986. Assembly of the prothrombin activator complex on rabbit alveolar macrophage high-affinity factor Xa receptors. J. Exp. Med. 164:1902-1914.
24. Tracy, P.B., L.L. Eide, and K.G. Mann. 1985. Human prothrombinase complex assembly and function on isolated peripheral blood cell populations. J. Biol. Chem. 260:2119-2124.
25. Altieri, D.C. 1995. Xa receptor EPR-1. FASEB (Fed. Am. Sroc. Exp. Biol.) J. 9:860-865.
26. Kasama, K., J. Komiyama, and W. Kiesel. 1993. Tissue factor pathway inhibitor and protease nexin-1 are major factor Xa binding proteins on the HepG2 cell surface. Blood. 81:676-682.
27. Sakai, T., and W. Kiesel. 1990. Binding of human factors X and Xa to HepG2 and J82 human tumor cell lines. J. Biol. Chem. 265:9105-9113.
28. Wu, X., M.H. Helfrich, M.A. Horton, L.P. Feigen, and J.B. Lefkowith. 1994. Fibrinogen mediates platelet-polymorphonuclear leukocyte cooperation during immune complex glomerulonephritis in rats. J. Clin, Invest. 94:928-936.
29. Nystedt, S., K. Emilsson, C. Wahlestedt, and J. Sundelin. 1994. Molecular cloning of a potential proteinase-activated receptor. Proc. Natl. Acad. Sci. USA. 91:9208-9212.
30. Appella, E., E.A. Robinson, S.J. Ullrich, M.P. Stoppelli, A. Corti, G. Cassani, and F. Blasi. 1987. The receptor-binding sequence of urokinase: a biological function for the growth-factor module of proteases. J. Biol. Chem. 262: 4437-4440.
31. Ambrosini, G., and D.C. Altieri. 1996. Molecular dissection of effector cell protease receptor-1 recognition of factor Xa. J. Biol. Chem. 271:1243-1248.
32. Cirino, G., C. Cicala, M. Bucci, L. Sorrentino, G. Ambrosini, G. DeDominicis, and D.C. Altieri. 1997. Factor Xa as an interface between coagulation and inflammation. Molecular mimicry of factor Xa association with effector cell protease receptor-1 induces acute inflammation in vivo. J. Clin. Invest. 99:2446-2451.
33. Herbert, J.M., E. Dupuy, M.C. Laplace, J.M. Zini, R. Bar-Shavit, and G. Tobelem. 1994. Thrombin induces endothelial cell growth via both a proteolytic and a nonproteolytic pathway. Biochem. J. 303:227-231.
34. Herbert, J.M., I. Lamarche, and F. Dol. 1992. Induction of vascular smooth muscle cell growth by selective activation of the thrombin receptor. Effect of heparin. FEBS (Fed. Eur. Biochem. Soc.) Lett. 301:155-158.
35. Herbert, J.M., A.F. Guy, I. Lamarche, A.M. Mares, P. Savi, and F. Dol. 1997. Intimal hyperplasia following vascular injury is not inhibited by an antisense thrombin receptor oligodeoxynucleotide. J. Cell. Physiol. 170:106-114.