Structural basis for inhibition promiscuity of dual specific thrombin and factor Xa blood coagulation inhibitors

Structure

Volumn 9, Issue 1, 2001, Pages 29-37

  Nar, Herbert ^a   Bauer, Margit ^a   Schmid, Angela ^a   Stassen, Jean Marie ^a   Wienen, Wolfgang ^a   Priepke, Henning W M ^a   Kauffmann, Iris K ^a   Ries, Uwe J ^a   Hauel, Norbert H ^a  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Blood coagulation; Crystal structure; Factor Xa; Inhibitor complexes; Thrombin

Indexed keywords

BENZAMIDINE DERIVATIVE; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 10A INHIBITOR; THROMBIN; THROMBIN INHIBITOR;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; DRUG BINDING; DRUG CONFORMATION; DRUG STRUCTURE; HYDROPHOBICITY; LIGAND BINDING; PRIORITY JOURNAL; STEREOSPECIFICITY; X RAY CRYSTALLOGRAPHY;

ANIMALS; BLOOD COAGULATION; BLOOD COAGULATION FACTOR INHIBITORS; CATTLE; CRYSTALLOGRAPHY, X-RAY; FACTOR XA; HUMANS; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; THROMBIN; THROMBOSIS; TRYPSIN;

EID: 0035151738     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(00)00551-7     Document Type: Article

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