Design of highly potent noncovalent thrombin inhibitors that utilize a novel lipophilic binding pocket in the thrombin active site

Journal of Medicinal Chemistry

Volumn 40, Issue 6, 1997, Pages 830-832

  Tucker, T J ^a   Lumma, W C ^a   Mulichak, A M ^a   Chen, Z ^a   Naylor Olsen, A M ^a   Lewis, S D ^a   Lucas, R ^a   Freidinger, R M ^a   Kuo, L C ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLASMIN; SERINE PROTEINASE; SULFONAMIDE; THROMBIN INHIBITOR; TISSUE PLASMINOGEN ACTIVATOR; TRYPSIN;

ARTICLE; DRUG BINDING SITE; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; LIPOPHILICITY; MOLECULAR MODEL; ORAL DRUG ADMINISTRATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYCLOHEXYLAMINES; DIPEPTIDES; DRUG DESIGN; FIBRINOLYTIC AGENTS; HYDROGEN BONDING; MOLECULAR STRUCTURE; PROTEIN BINDING; THROMBIN;

EID: 0030895222     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960762y     Document Type: Article

References (12)