Migration and function of FoxP3+ regulatory T cells in the hematolymphoid system

Experimental Hematology

Volumn 34, Issue 8, 2006, Pages 1033-1040

  Kim, Chang H ^a  

^a Purdue University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR FOXP3;

AUTOIMMUNITY; CELL DIFFERENTIATION; CELL FUNCTION; CELL MIGRATION; GRAFT VERSUS HOST REACTION; HEMATOPOIESIS; HUMAN; LYMPH NODE; LYMPHOID TISSUE; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SPLEEN; STEM CELL; T LYMPHOCYTE;

ANIMALS; CELL MOVEMENT; FORKHEAD TRANSCRIPTION FACTORS; GRAFT VS HOST DISEASE; HUMANS; L-SELECTIN; LYMPHOID TISSUE; RECEPTORS, CHEMOKINE; T-LYMPHOCYTES, REGULATORY;

EID: 33746098905     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2006.03.014     Document Type: Review

References (100)

1. Baum J., Liebermann G., and Frenkel E.P. The effect of immunologically induced lymphopenia on antibody formation. J Immunol 102 (1969) 187-193
2. Baker P.J., Barth R.F., Stashak P.W., and Amsbaugh D.F. Enhancement of the antibody response to type 3 pneumococcal polysaccharide in mice treated with antilymphocyte serum. J Immunol 104 (1970) 1313-1315
3. Kerbel R.S., and Eidinger D. Variable effects of anti-lymphocyte serum on humoral antibody formation: role of thymus dependency of antigen. J Immunol 106 (1971) 917-926
4. Katz D.H. The allogeneic effect on immune responses: model for regulatory influences of T lymphocytes on the immune system. Transplant Rev 12 (1972) 141-179
5. Gershon R.K., and Kondo K. Infectious immunological tolerance. Immunology 21 (1971) 903-914
6. Katz D.H., and Benacerraf B. The regulatory influence of activated T cells on B cell responses to antigen. Adv Immunol 15 (1972) 1-94
7. Okumura K., Herzenberg L.A., Murphy D.B., and McDevitt H.O. Selective expression of H-2 (i-region) loci controlling determinants on helper and suppressor T lymphocytes. J Exp Med 144 (1976) 685-698
8. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., and Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155 (1995) 1151-1164
9. Sakaguchi S., and Thymus Sakaguchi N. T cells and autoimmunity: Various causes but a common mechanism of autoimmune disease. In: Coutinho A., and Kazatchkine M. (Eds). Autoimmunity: Physiology and Disease (1994), Wiley-Liss, New York 203-227
10. + T cells. J Exp Med 178 (1993) 237-244
11. + T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int Immunol 5 (1993) 1461-1471
12. + T cells. Immunity 1 (1994) 553-562
13. von Boehmer H. Mechanisms of suppression by suppressor T cells. Nat Immunol 6 (2005) 338-344
14. + regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 6 (2005) 345-352
15. + suppressor T cells. Novartis Found Symp 252 (2003) 24-36
16. Russel W., Russel L., and Gower J. Exceptional inheritiance of a sex-linked gene in the mouse explained on the basis that the X/O sex-chromosome constitution is female. Proc Natl Acad Sci U S A 45 (1959) 554-560
17. Godfrey V.L., Wilkinson J.E., and Russell L.B. X-linked lymphoreticular disease in the scurfy (sf) mutant mouse. Am J Pathol 138 (1991) 1379-1387
18. Brunkow M.E., Jeffery E.W., Hjerrild K.A., et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 27 (2001) 68-73
19. Hori S., Nomura T., and Sakaguchi S. Control of regulatory T cell development by the transcription factor FoxP3. Science 299 (2003) 1057-1061
20. + T cell effector function. J Immunol 171 (2003) 1216-1223
21. + regulatory T cells. Nat Immunol 4 (2003) 330-336
22. Schubert L.A., Jeffery E., Zhang Y., Ramsdell F., and Ziegler S.F. Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J Biol Chem 276 (2001) 37672-37679
23. Bettelli E., Dastrange M., and Oukka M. FoxP3 interacts with nuclear factor of activated T cells and NF-κ B to repress cytokine gene expression and effector functions of T helper cells. Proc Natl Acad Sci U S A 102 (2005) 5138-5143
24. Kretschmer K., Apostolou I., Hawiger D., Khazaie K., Nussenzweig M.C., and von Boehmer H. Inducing and expanding regulatory T cell populations by foreign antigen. Nat Immunol 6 (2005) 1219-1227
25. + T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med 192 (2000) 1213-1222
26. + regulatory T cells by targeting of antigens to immature dendritic cells. Blood 101 (2003) 4862-4869
27. Min W.P., Zhou D., Ichim T.E., et al. Inhibitory feedback loop between tolerogenic dendritic cells and regulatory T cells in transplant tolerance. J Immunol 170 (2003) 1304-1312
28. + T cells by human mature autologous dendritic cells. Eur J Immunol 34 (2004) 762-772
29. + regulatory T cells from human peripheral blood. J Immunol 166 (2001) 7282-7289
30. - precursors. J Immunol 169 (2002) 4183-4189
31. - precursors. Am J Transplant 4 (2004) 1614-1627
32. + precursors. J Immunol 175 (2005) 6107-6116
33. + regulatory T cell compartment. J Immunol 173 (2004) 2227-2230
34. Gregori S., Casorati M., Amuchastegui S., Smiroldo S., Davalli A.M., and Adorini L. Regulatory T cells induced by 1 α, 25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance. J Immunol 167 (2001) 1945-1953
35. + T cells. J Immunol 175 (2005) 1483-1490
36. - cells to develop suppressive activity: the role of IL-2, TGF-β, and IL-10. J Immunol 172 (2004) 5213-5221
37. + regulatory T cells. J Immunol 172 (2004) 5986-5993
38. + regulatory T cells at the single-cell level. Eur J Immunol 35 (2005) 1681-1691
39. Fontenot J.D., Rasmussen J.P., Williams L.M., Dooley J.L., Farr A.G., and Rudensky A.Y. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22 (2005) 329-341
40. Fontenot J.D., and Rudensky A.Y. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor FoxP3. Nat Immunol 6 (2005) 331-337
41. + regulatory T cells is mediated by cell surface-bound transforming growth factor β. J Exp Med 194 (2001) 629-644
42. + regulatory T cells by oral antigen administration. J Immunol 167 (2001) 4245-4253
43. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 188 (1998) 287-296
44. + immunoregulatory cells. J Immunol 167 (2001) 1137-1140
45. + regulatory T cells suppress NKT cell functions. Cancer Res 63 (2003) 4516-4520
46. + regulatory T cells. Hum Immunol 66 (2005) 222-230
47. + regulatory T cells. J Immunol 175 (2005) 4180-4183
48. + regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells. Eur J Immunol 30 (2000) 1538-1543
49. + human thymocytes. J Exp Med 196 (2002) 379-387
50. + regulatory T cells. Eur J Immunol 32 (2002) 2888-2896
51. Grohmann U., Orabona C., Fallarino F., et al. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat Immunol 3 (2002) 1097-1101
52. Choi B.M., Pae H.O., Jeong Y.R., Kim Y.M., and Chung H.T. Critical role of heme oxygenase-1 in FoxP3-mediated immune suppression. Biochem Biophys Res Commun 327 (2005) 1066-1071
53. Grossman W.J., Verbsky J.W., Barchet W., Colonna M., Atkinson J.P., and Ley T.J. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity 21 (2004) 589-601
54. + regulatory cells involves a granzyme B-dependent, perforin-independent mechanism. J Immunol 174 (2005) 1783-1786
55. Kim C.H., Rott L., Kunkel E.J., et al. Rules of chemokine receptor association with T cell polarization in vivo. J Clin Invest 108 (2001) 1331-1339
56. Sallusto F., Lenig D., Forster R., Lipp M., and Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401 (1999) 708-712
57. Campbell J.J., Murphy K.E., Kunkel E.J., et al. CCR7 expression and memory T cell diversity in humans. J Immunol 166 (2001) 877-884
58. Warnock R.A., Campbell J.J., Dorf M.E., Matsuzawa A., McEvoy L.M., and Butcher E.C. The role of chemokines in the microenvironmental control of T versus B cell arrest in Peyer's patch high endothelial venules. J Exp Med 191 (2000) 77-88
59. Stein J.V., Rot A., Luo Y., et al. The CC chemokine thymus-derived chemotactic agent 4 (TCA-4, secondary lymphoid tissue chemokine, 6Ckine, exodus-2) triggers lymphocyte function-associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules. J Exp Med 191 (2000) 61-76
60. Ngo V.N., Tang H.L., and Cyster J.G. Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naive T cells and activated B cells. J Exp Med 188 (1998) 181-191
61. Yoshida R., Nagira M., Kitaura M., Imagawa N., Imai T., and Yoshie O. Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7. J Biol Chem 273 (1998) 7118-7122
62. Kim C.H., Pelus L.M., White J.R., Applebaum E., Johanson K., and Broxmeyer H.E. CK β-11/macrophage inflammatory protein-3 β/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells. J Immunol 160 (1998) 2418-2424
63. Hromas R., Kim C.H., Klemsz M., et al. Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension. J Immunol 159 (1997) 2554-2558
64. Gunn M.D., Tangemann K., Tam C., Cyster J.G., Rosen S.D., and Williams L.T. A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. Proc Natl Acad Sci U S A 95 (1998) 258-263
65. Langenkamp A., Messi M., Lanzavecchia A., and Sallusto F. Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells. Nat Immunol 1 (2000) 311-316
66. Kim C.H. Chemokine-chemokine receptor network in immune cell trafficking. Curr Drug Targets Immune Endocr Metabol Disord 4 (2004) 343-361
67. Moser B., Wolf M., Walz A., and Loetscher P. Chemokines: multiple levels of leukocyte migration control. Trends Immunol 25 (2004) 75-84
68. D'Ambrosio D., Iellem A., Bonecchi R., et al. Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells. J Immunol 161 (1998) 5111-5115
69. Sallusto F., Lenig D., Mackay C.R., and Lanzavecchia A. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J Exp Med 187 (1998) 875-883
70. Zingoni A., Soto H., Hedrick J.A., et al. The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells. J Immunol 161 (1998) 547-551
71. Imai T., Nagira M., Takagi S., et al. Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine. Int Immunol 11 (1999) 81-88
72. + regulatory T cells play no apparent role in the acute humoral response to intact Streptococcus pneumoniae. Infect Immun 73 (2005) 4427-4431
73. + human thymocytes. J Exp Med 196 (2002) 379-387
74. + regulatory T cells. J Exp Med 194 (2001) 847-853
75. Lim H.W., Hillsamer P., and Kim C.H. Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses. J Clin Invest 114 (2004) 1640-1649
76. Liu Y.J., Kadowaki N., Rissoan M.C., and Soumelis V. T cell activation and polarization by DC1 and DC2. Curr Top Microbiol Immunol 251 (2000) 149-159
77. Bystry R.S., Aluvihare V., Welch K.A., Kallikourdis M., and Betz A.G. B cells and professional APCs recruit regulatory T cells via CCL4. Nat Immunol 2 (2001) 1126-1132
78. + suppressor T cells. Eur J Immunol 33 (2003) 1488-1496
79. + regulatory T cells are numerically deficient in acute and chronic GvHD. Blood 107 (2005) 1717-1723
80. + splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7. J Immunol 169 (2002) 2461-2465
81. Sarween N., Chodos A., Raykundalia C., Khan M., Abbas A.K., and Walker L.S. CD4+CD25+ cells controlling a pathogenic CD4 response inhibit cytokine differentiation, CXCR-3 expression, and tissue invasion. J Immunol 173 (2004) 2942-2951
82. + regulatory T cells. J Exp Med 199 (2004) 303-313
83. Curiel T.J., Coukos G., Zou L., et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 10 (2004) 942-949
84. + regulatory T cells that traffic through CXCL12/CXCR4 signals. Cancer Res 64 (2004) 8451-8455
85. Shull M.M., Ormsby I., Kier A.B., et al. Targeted disruption of the mouse transforming growth factor-β 1 gene results in multifocal inflammatory disease. Nature 359 (1992) 693-699
86. Waterhouse P., Penninger J.M., Timms E., et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270 (1995) 985-988
87. Kim CH. Chemokines and their receptors in hematopoietic cell development and function. In: Schwiebert L, ed. Chemokines, Chemokine Receptors, and Disease. Current Topics in Membranes 2005;55:115-142.
88. Kanangat S., Blair P., Reddy R., et al. Disease in the scurfy (sf) mouse is associated with overexpression of cytokine genes. Eur J Immunol 26 (1996) 161-165
89. Clark L.B., Appleby M.W., Brunkow M.E., Wilkinson J.E., Ziegler S.F., and Ramsdell F. Cellular and molecular characterization of the scurfy mouse mutant. J Immunol 162 (1999) 2546-2554
90. Smyk-Pearson S.K., Bakke A.C., Held P.K., and Wildin R.S. Rescue of the autoimmune scurfy mouse by partial bone marrow transplantation or by injection with T-enriched splenocytes. Clin Exp Immunol 133 (2003) 193-199
91. + immune regulatory cells inhibits graft-versus-host disease lethality. Blood 99 (2002) 3493-3499
92. + regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med 196 (2002) 389-399
93. + immunoregulatory T cells: new therapeutics for graft-versus-host disease. J Exp Med 196 (2002) 401-406
94. + T cells promote engraftment and tolerance following MHC-mismatched hematopoietic cell transplantation. Blood 105 (2005) 1828-1836
95. + T-regulatory cells are potent inhibitors of GVHD and BM graft rejection. Blood 104 (2004) 3804-3812
96. + regulatory T cells protects from lethal acute GVHD. Blood 105 (2005) 2220-2226
97. + regulatory T cells during acute graft-versus-host disease. Blood 106 (2005) 3300-3307
98. + regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med 9 (2003) 1144-1150
99. + regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia. J Clin Invest 112 (2003) 1688-1696
100. + regulatory T cells in patients with chronic graft-versus-host disease. Blood 106 (2005) 2903-2911