Critical role of heme oxygenase-1 in Foxp3-mediated immune suppression

Biochemical and Biophysical Research Communications

Volumn 327, Issue 4, 2005, Pages 1066-1071

  Choi, Byung Min ^a   Pae, Hyun Ock ^a   Jeong, Young Ran ^a   Kim, Young Myeong ^b   Chung, Hun Taeg ^a  

^a School of Medicine   (South Korea)

^b Kangwon National University   (South Korea)

Author keywords

Foxp3; Heme oxygenase; Immune suppression; T cells

Indexed keywords

CD4 ANTIGEN; HEME OXYGENASE 1; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3;

ARTICLE; CELL COMMUNICATION; CELL FUNCTION; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LEUKEMIA CELL LINE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; DNA-BINDING PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, LEUKEMIC; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HUMANS; IMMUNE TOLERANCE; JURKAT CELLS; MEMBRANE PROTEINS; RECEPTORS, INTERLEUKIN-2; TRANSFECTION;

EID: 12344335548     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.12.106     Document Type: Article

References (19)

1. S. Sakaguchi Regulatory T cells: key controllers of immunologic self-tolerance Cell 101 2000 455
2. L. Van Parijs, and A.K. Abbas Hemeostasis and self-tolerance in the immune system: turning lymphocytes off Science 280 1998 243 248
3. K.J. Maloy, and F. Powrie Regulatory T cells in the control of immune pathology Nat. Immunol. 2 2001 816 822
4. + regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance Immunol. Rev. 182 2001 18 32
5. + suppressor T cells: more questions than answers Nat. Rev. Immunol. 2 2002 389 400
6. S. Sakaguchi, N. Sakaguchi, M. Asano, M. Itoh, and M. Toda Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases J. Immunol. 155 1995 1151 1164
7. + T cells Biochem. Biophys. Res. Commun. 306 2003 701 705
8. B.M. Choi, H.O. Pae, Y.R. Jeong, G.S. Oh, C.D. Jun, B.R. Kim, Y.M. Kim, and H.T. Chung Overexpression of heme oxygenase (HO)-1 renders Jurkat T cells resistant to Fas-mediated apoptosis: involvement of iron released by HO-1 Free Radic. Biol. Med. 36 2004 858 871
9. H.O. Pae, G.S. Oh, B.M. Choi, S.C. Chae, Y.M. Kim, K.R. Chung, and H.T. Chung Carbon monoxide produced by heme oxygenase-1 suppresses T cell proliferation via inhibition of IL-2 production J. Immunol. 172 2004 4744 4751
10. S. Hori, T. Nomura, and S. Sakaguchi Control of regulatory T cell development by the transcription factor Foxp3 Science 299 2003 1057 1061
11. + T regulatory cells Nat. Immunol. 4 2003 337 342
12. + regulatory T cells Nat. Immunol. 4 2003 330 336
13. E.A. Tivol, F. Borriello, A.N. Schweitzer, W.P. Lynch, J.A. Bluestone, and A.H. Sharpe Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4 Immunity 3 1995 541 547
14. P. Waterhouse, J.M. Penninger, E. Timms, A. Wakeham, A. Shahinian, K.P. Lee, C.B. Thompson, H. Griesser, and T.W. Mak Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4 Science 270 1995 985 988
15. A.B. Kulkarni, C.G. Huh, D. Becker, A. Geiser, M. Lyght, K.C. Flanders, A.B. Roberts, M.B. Sporn, J.M. Ward, and S. Karlsson Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death Proc. Natl. Acad. Sci. USA 90 1993 770 774
16. + regulatory T cells Int. Immunol. 16 2004 1643 1656
17. R. Song, R.S. Mahidhara, Z. Zhou, R.A. Hoffman, D.W. Seol, R.A. Flavell, T.R. Billiar, L.E. Otterbein, and A.M. Choi Carbon monoxide inhibits T lymphocyte proliferation via caspase-dependent pathway J. Immunol. 172 2004 1220 1226
18. J. Woo, S. Iyer, M.C. Cornejo, N. Mori, L. Gao, I. Sipos, M. Maines, and R. Buelow Stress protein-induced immunosuppression: inhibition of cellular immune effector functions following overexpression of haem oxygenase (HSP 32) Transpl. Immunol. 6 1998 84 93
19. M.H. Kapturczak, C. Wasserfall, T. Brusko, M. Campbell-Thompson, T.M. Ellis, M.A. Atkinson, and A. Agarwal Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse Am. J. Pathol. 165 2004 1045 1053