High resolution mapping of mast cell membranes reveals primary and secondary domains of FcεRI and LAT

Journal of Cell Biology

Volumn 154, Issue 3, 2001, Pages 645-658

  Wilson, Bridget S ^a   Pfeiffer, Janet R ^a   Surviladze, Zurab ^a   Gaudet, Elizabeth A ^a   Oliver, Janet M ^a  

^a UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

Author keywords

Gab2; LAT; Microdomains; Phosphatidylinositol 3 kinase; PLC

Indexed keywords

ANTIBODY; BINDING PROTEIN; FC RECEPTOR; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; IMMUNOGLOBULIN E RECEPTOR; LAT PROTEIN; LINK PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY LABELING; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; ENZYME ACTIVITY; MAST CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN DOMAIN; PROTEIN LOCALIZATION; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CARRIER PROTEINS; CELL FRACTIONATION; CELL MEMBRANE; CROSS-LINKING REAGENTS; IMMUNOHISTOCHEMISTRY; ISOENZYMES; LEUKEMIA, BASOPHILIC, ACUTE; LYMPHOCYTE ACTIVATION; MAST CELLS; MEMBRANE MICRODOMAINS; MEMBRANE PROTEINS; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHOPROTEINS; RATS; RECEPTORS, IGE; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0035817631     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200104049     Document Type: Article

References (57)

1. The caveolae membrane system
2. Wortmann-insensitive phosphorylation, translocation and activation of PLCγ1, but not PLCγ2, in antigen-stimulated RBL-2H3 mast cells
3. 2+ mobilization in antigen-stimulated mast cells
4. Control of cell surface topography
5. The cell surface
6. Functions of lipid rafts in biological membranes
7. Lipid rafts and their role in signal transduction-mast cells as a model
8. Signaling takes shape in the immune system
9. Lipid microdomains in cell-surface membranes
10. lyn to detergent-resistant membrane domains accompanies cellular signaling
11. Compartmentalized activation of the high affinity immunoglobulin E receptor within membrane domains
12. Structural aspects of the association of FcεRI with detergent-resistant membranes
13. LAT is required for TCR-mediated activation of PLCγ1 and the Ras pathway
14. T cell activation-dependent association between the p85 subunit of the phosphatidylinositol 3-kinase and Grb2/phospholipase Cγ1-binding phosphotyrosyl protein pp36/38
15. The docking molecule Gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common γ chain-using cytokines
16. Evidence that phospholipase C-γ2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor γ-chain after stimulation of the collagen receptor glycoprotein VI in human platelets
17. Cloning of p97/Gab2, the major SHP-2 binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation
18. One-dimensional thin-layer chromatography of all known D-3 and D-4 isomers of phosphoinosi tides
19. Interactions between FcERI and lipid raft components are regulated by the actin cytoskeleton
20. A Grb2-associated docking protein in EGF- and insulin-receptor signalling
21. GPI-microdomains: A role in signalling via immunoreceptors
22. Involvement of LAT, Gads and Grb2 in compartmentation of SLP-76 to the plasma membrane
23. Looking at lipid rafts?
24. Receptor specificity of growth factor-stimulated synthesis of 3-phosphorylated inositol lipids in Swiss 3T3 cells
25. A role for the adaptor protein LAT in human NK cell-mediated cytotoxicity
26. A supramolecular basis for CD45 regulation during T cell activation
27. Tyrosine phosphorylation of the linker for activator of T cells in mast cells by stimulation with the high affinity IgE receptor
28. Membrane rafts and signaling by the multichain immune recognition receptor
29. 2+ responses of RBL-2H3 cells
30. Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes
31. Monoclonal dintrophenyl-specific murine IgE antibody: Preparation, isolation and characterization
32. Signaling via LAT (linker for T-cell activation) and Syk/ZAP-70 is required for ERK activation and NFAT transcriptional activation following CD2 stimulation
33. Threedimensional segregation of supramolecular activation in T cells
34. Adaptor proteins in lymphocyte antigen-receptor signaling
35. Gabfamily adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors
36. Effects of phagocytosis and colchicine on the distribution of lectin-binding sites on cell surfaces
37. LAT is required for tyrosine phosphorylation of phospholipase Cγ2 and platelet activity by the collagen receptor GPVI
38. The role of SLP-76 and LAT in lymphocyte development
39. A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling
40. LAT is essential for FcεRI-mediated mast cell activation
41. Simultaneous visualization of LDL receptor distribution and clathrin lattices on membranes torn from the upper surface of cultured cells
42. Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
43. The relationship of IgE receptor topography to secretion in RBL-2H3 mast cells
44. Functional rafts in cell membranes
45. The fluid mosaic model of the structure of cell membranes
46. 3 production
47. TCR signaling induces selective exclusion of CD43 from the T cell-antigen-presenting cell contact site
48. Compartmentalized IgE receptor-mediated signal transduction in living cells
49. Functional heterogeneity of Thy-1 membrane microdomains in rat basophilic leukemia cells
50. Translocation and reversible localization of signaling proteins: A dynamic future for signal transduction
51. Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils
52. The adaptor protein LAT enhances Fcγ receptor-mediated signal transduction in myeloid cells
53. Effect of phagocytosis on membrane transport ofnon-electrolytes
54. Molecular cloning of the cDNA encoding pp36: A tyrosine phosphotylated adaptor protein selectively expressed by T cells and natural killer cells
55. Observing FcεRI signaling from the inside of the mast cell membrane
56. LAT palmitoylation: Its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation
57. Association of Grb2, Gads, and phospholipase Cγ1 with phosphorylated LAT tyrosine residues