Deduction of functional peptide motifs in scorpion toxins

Journal of Peptide Science

Volumn 12, Issue 6, 2006, Pages 420-427

  Tan, Paul T J ^a,b   Ranganathan, Shoba ^b,c   Brusic, Vladimir ^a,d  

^a INSTITUTE FOR INFOCOMM RESEARCH   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c MACQUARIE UNIVERSITY   (Australia)

^d UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Binding motifs; Ion channel subtypes; Mutation; Scorpion toxins

Indexed keywords

ION CHANNEL; PEPTIDE; SCORPION VENOM;

ARTICLE; DATA BASE; EXTRACTION; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MOTIF; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; CHLORIDE CHANNELS; DATABASES, FACTUAL; KV1.1 POTASSIUM CHANNEL; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SCORPION VENOMS; SCORPIONS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP;

SCORPIONES;

EID: 33745322044     PISSN: 10752617     EISSN: 10991387     Source Type: Journal    
DOI: 10.1002/psc.744     Document Type: Article

References (51)

1. + channels. Curr. Pharm. Des. 2004; 10: 1057-1067.
2. Mouhat S, Jouirou B, Mosbah A, De Waard M, Sabatier JM. Diversity of folds in animal toxins acting on ion channels. Biochem. J. 2004; 378: 717-726.
3. Arnon T, Potikha T, Sher D, Elazar M, Mao W, Tal T, Bosmans F, Tytgat J, Ben-Arie N, Zlotkin E. BjalphaIT: a novel scorpion alpha-toxin selective for insects-unique pharmacological tool. Insect Biochem. Mol. Biol. 2005; 35: 187-195.
4. Gilquin B, Bourgoin M, Menez R, Le Du MH, Servent D, Zinn-Justin S, Menez A. Motions and structural variability within toxins: implication for their use as scaffolds for protein engineering. Protein Sci. 2003, 12: 266-277.
5. Maria WS, Velarde DT, Alvarenga LM, Nguyen C, Villard S, Granier C, Chavez-Olortegui C. Localization of epitopes in the toxins of Tityus serrulatus scorpions and neutralizing potential of therapeutic antivenoms. Toxicon 2005; 46: 210-217.
6. Gazarian KG, Gazarian T, Hernandez R, Possani LD. Immunology of scorpion toxins and perspectives for generation of anti-venom vaccines. Vaccine 2005; 23: 3357-3368.
7. Gilles N, Gurevitz M, Gordon D. Allosteric interactions among pyrethroid, brevetoxin, and scorpion toxin receptors on insect sodium channels raise an alternative approach for insect control. FEBS Lett 2003; 540: 81-85.
8. Regev A, Rivkin H, Inceoglu B, Gershburg E, Hammock BD, Gurevitz M, Chejanovsky N. Further enhancement of baculovirus insecticidal efficacy with scorpion toxins that interact cooperatively. FEBS Lett. 2003; 537: 106-110.
9. Wang J, Chen Z, Du J, Sun Y, Liang A. Novel insect resistance in Brassica napus developed by transformation of chitinase and scorpion toxin genes. Plant Cell Rep. 2005, 24: 549-555.
10. Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 1997; 25: 3389-3402.
11. Pearson WR. Flexible sequence similarity searching with the FASTA3 program package. Methods Mol. Biol. 2000: 132: 185-219.
12. Hulo N, Sigrist CJ, Le Saux V, Langendijk-Genevaux PS, Bordoli L, Gattiker A, De Castro E, Bucher P, Bairoch A. Recent improvements to the PROSITE database. Nucleic Acids Res. 2004; 32: Database issue: D134-D137.
13. Attwood TK, Bradley P, Flower DR, Gaulton A, Maudling N, Mitchell AL, Moulton G, Nordle A, Paine K, Taylor P, Uddin A, Zygouri C. PRINTS and its automatic supplement, prePRINTS. Nucleic Acids Res. 2003; 31: 400-402.
14. Cohen L, Karbat I, Gilles N, Ilan N, Benveniste M, Gordon D, Gurevitz M. Common features in the functional surface of scorpion β-toxins and elements that confer specificity for insect and mammalian voltage-gated sodium channels. J. Biol. Chem. 2005; 280: 5045-5053.
15. Huys I, Tytgat J. Evidence for a function-specific mutation in the neurotoxin, parabutoxin 3. Eur. J. Neurosci. 2003; 17: 1786-1792.
16. Benson DA, Karsch-Mizrachi I, Lipman DJ, Ostell J, Wheeler DL. GenBank. Nucleic Acids Res. 2005; 33: Database Issue: D34-D38.
17. Bairoch A, Boeckmann B, Ferro S, Gasteiger E. Swiss-prot: juggling between evolution and stability. Brief. Bioinform. 2004; 5: 39-55.
18. Deshpande N, Addess KJ, Bluhm WF, Merino-Ott JC, Townsend-Merino W, Zhang Q, Knezevich C, Xie L, Chen L, Feng Z, Green RK, Flipper-Anderson JL, Westbrook J, Berman HM, Bourne PE. The RCSB protein data bank: a redesigned query system and relational database based on the mmCIF schema. Nucleic Acids Res. 2005; 33: Database Issue: D233-D237.
19. Kong L, Lee BT, Tong JC, Tan TW, Ranganathan S. SDPMOD: an automated comparative modeling server for small disulfide-bonded proteins. Nucleic Acids Res. 2004; 32: W356-W359.
20. Srinivasan KN, Gopalakrishnakone P, Tan PT, Chew KC, Cheng B, Kini RM, Koh JL, Seah SH, Brusic V. SCORPION, a molecular database of scorpion toxins. Toxicon 2002; 40: 23-31.
21. Tan PT, Srinivasan KN, Seah SH, Koh JL, Tan TW, Ranganathan S, Brusic V. Accurate prediction of scorpion toxin functional properties from primary structures. J. Mol. Graph. Model. 2005; 24: 17-24.
22. Thompson JD, Higgins DG, Gibson TJ. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 1994; 22: 4673-4680.
23. Kumar S, Tamura K, Nei M. MEGA3: integrated software for molecular evolutionary genetics analysis and sequence alignment. Brief. Bioinform. 2004; 5: 150-163.
24. Saitou N, Nei M. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol. Biol. Evol. 1987; 4: 406-425.
25. Koschak A, Bugianesi RM, Mitterdorfer J, Kaczorowski GJ, Garcia ML, Knaus HG. Subunit composition of brain voltage-gated potassium channels determined by hongotoxin-1, a novel peptide derived from Centruroides limbatus venom. J. Biol. Chem. 1998; 273: 2639-2644.
26. Hassani O, Mansuelle P, Cestele S, Bourdeaux M, Rochat H, Sampieri F. Role of lysine and tryptophan residues in the biological activity of toxin VII (Ts gamma) from the scorpion Tityus serrulatus. Eur. J. Biochem. 1999; 260: 76-86.
27. Gattiker A, Gasteiger E, Bairoch A. ScanProsite: a reference implementation of a PROSITE scanning tool. Appl. Bioinformatics 2002; 1: 107-108.
28. + channel selectivity filter by mutant cycle-based structure analysis. Neuron 1996, 16: 131-139.
29. + channels. Faseb J. 2004; 18: 683-689.
30. + channels. J. Biol. Chem. 2004; 279: 8206-8211.
31. Karbat I, Frolow F, Froy O, Gilles N, Cohen L, Turkov M, Gordon D, Gurevitz M. Molecular basis of the high insecticidal potency of scorpion alpha-toxins. J. Biol. Chem. 2004; 279: 31 679-31 686.
32. Zilberberg N, Froy O, Loret E, Cestele S, Arad D, Gordon D, Gurevitz M. Identification of structural elements of a scorpion alpha-neurotoxin important for receptor site recognition. J. Biol. Chem. 1997; 272: 14810-14816.
33. Wang CG, Gilles N, Hamon A, Le Gall F, Stankiewicz M, Pelhate M, Xiong YM, Wang DC, Chi CW. Exploration of the functional site of a scorpion alpha-like toxin by site-directed mutagenesis. Biochemistry 2003; 42: 4699-4708.
34. Sun YM, Bosmans F, Zhu RH, Goudet C, Xiong YM, Tytgat J, Wang DC. Importance of the conserved aromatic residues in the scorpion alpha-like toxin BmK M1: the hydrophobic surface region revisited. J. Biol. Chem. 2003; 278: 24125-24131.
35. He XL, Li HM, Zeng ZH, Liu XQ, Wang M, Wang DC. Crystal structures of two alpha-like scorpion toxins: non-proline cis peptide bonds and implications for new binding site selectivity on the sodium channel. J. Mol. Biol. 1999; 292: 125-135.
36. Korołkova YV, Bocharov EV, Angelo K, Maslennikov IV, Grinenko OV, Lipkin AV, Nosyreva ED, Pluzhnikov KA, Olesen SP, Arseniev AS, Grishin EV. New binding site on common molecular scaffold provides HERG channel specificity of scorpion toxin BeKm-1. J. Biol. Chem. 2002; 277: 43104-43109.
37. + channels with increased affinity. Biochemistry 1993; 32: 2763-2770.
38. + channels. Structure-activity analysis using synthetic analogs. Int. J. Pept. Protein Res. 1994; 43: 486-495.
39. Ca2. J. Biol. Chem. 2001; 276: 43145-43151.
40. Wu JJ, He LL, Zhou Z, Chi CW. Gene expression, mutation, and structure-function relationship of scorpion toxin BmPO5 active on SK(Ca) channels. Biochemistry 2002; 41: 2844-2849.
41. Lecomte C, Ferrat G, Fajloun Z, Van Rietschoten J, Rochat H, Martin-Eauclaire MF, Darbon H, Sabatier JM. Chemical synthesis and structure-activity relationships of Ts kappa, a novel scorpion toxin acting on apamin-sensitive SK channel. J. Pept. Res. 1999; 54: 369-376.
42. + channel. Biophys. J. 1993; 65: 1613-1619.
43. Dauplais M, Lecoq A, Song J, Cotton J, Jamin N, Gilquin B, Roumestand C, Vita C, de Medeiros CL, Rowan EG, Harvey AL, Menez A. On the convergent evolution of animal toxins. Conservation of a diad of functional residues in potassium channel-blocking toxins with unrelated structures. J. Biol. Chem. 1997; 272: 4302-4309.
44. + channel structure from a complete functional map of the molecular surface of charybdotoxin. Biochemistry 1994; 33: 443-450.
45. Park CS, Miller C. Mapping function to structure in a channel-blocking peptide: electrostatic mutants of charybdotoxin. Biochemistry 1992; 31: 7749-7755.
46. Galvez A, Gimenez-Gallego G, Reuben JP, Roy-Contancin L, Feigenbaum P, Kaczorowski GJ, Garcia ML. Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus. J. Biol. Chem. 1990; 265: 083 11-90.
47. v channels. FEBS Lett. 2002; 527: 298-302.
48. Zuo XP, Ji YH. Molecular mechanism of scorpion neurotoxins acting on sodium channels: insight into their diverse selectivity. Mol. Neurobiol. 2004; 30: 265-278.
49. Korn SJ, Trapani JG. Potassium channels. IEEE Trans. Nanobioscience 2005: 4: 21-33.
50. + channels: what is the difference? Trends Pharmacol. Sci. 2003; 24: 446-448; author reply 448-449.
51. Mouhat S, Mosbah A, Visan V, Wulff H, Delepierre M, Darbon H, Grissmer S, De Waard M, Sabatier JM. The 'functional' dyad of scorpion toxin Pi1 is not itself a prerequisite for toxin binding to the voltage-gated Kv1.2 potassium channels. Biochem. J. 2004; 377: 25-36.