Conversion of a scorpion toxin agonist into an antagonist highlights an acidic residue involved in voltage sensor trapping during activation of neuronal Na+ channels

FASEB Journal

Volumn 18, Issue 6, 2004, Pages 683-689

  Izhar, Karbat ^a   Lior, Cohen ^a   Nicolas, Gilles ^b   Gordon, Dalia ^a   Michael, Gurevitz ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b CEA SACLAY   (France)

Author keywords

Competitive antagonist; Scorpion toxin; Sodium channel; Voltage sensor

Indexed keywords

ARGININE; GLUTAMIC ACID; POLYPEPTIDE; SCORPION BETA TOXIN; SCORPION VENOM; SCORPION VENOM AGONIST; SCORPION VENOM ANTAGONIST; SODIUM CHANNEL; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BIOSENSOR; CHANNEL GATING; CIRCULAR DICHROISM; COMPETITIVE INHIBITION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ELECTRIC POTENTIAL; MEMBRANE DEPOLARIZATION; MEMBRANE PERMEABILITY; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SCORPION; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; SPIDER; TOXICITY TESTING; TOXIN ANALYSIS; TOXIN STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; DIPTERA; GLUTAMIC ACID; INSECT PROTEINS; ION CHANNEL GATING; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEURONS; NEUROTOXINS; PERIPLANETA; SCORPION VENOMS; SEQUENCE ALIGNMENT; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

ARANEAE; SCORPIONES;

EID: 1842454965     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.03-0733com     Document Type: Article

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