New binding site on common molecular scaffold provides HERG channel specificity of scorpion toxin BeKm-1

Journal of Biological Chemistry

Volumn 277, Issue 45, 2002, Pages 43104-43109

  Korolkova, Yuliya V ^a,b   Bocharov, Eduard V ^a   Angelo, Kamilla ^a   Maslennikov, Innokenty V ^a   Grinenko, Olga V ^a   Lipkin, Aleksey V ^a   Nosyreva, Elena D ^a   Pluzhnikov, Kirill A ^a   Olesen, Søren Peter ^a   Arseniev, Alexander S ^a   Grishin, Eugene V ^a  

^a SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BIODIVERSITY; GENES; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE; STRUCTURE (COMPOSITION);

COMMON MOLECULAR SCAFFOLD;

BIOCHEMISTRY;

ARGININE; LYSINE; MEMBRANE PROTEIN; POTASSIUM CHANNEL; PROTEIN BEKM 1; PROTEIN HERG; SCORPION VENOM; TYROSINE; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; BETA SHEET; BINDING SITE; CONTROLLED STUDY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; TOXIN ANALYSIS; TOXIN STRUCTURE;

AMINO ACID SEQUENCE; BINDING SITES; CATION TRANSPORT PROTEINS; DNA-BINDING PROTEINS; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PLASMIDS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN SUBUNITS; RECOMBINANT PROTEINS; SCORPION VENOMS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SOLUTIONS; SUBSTRATE SPECIFICITY; TRANS-ACTIVATORS;

SCORPIONES;

EID: 0037044745     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M204083200     Document Type: Article

References (44)

1. Miller, C. (1995) Neuron 15, 5-10
2. Tytgat, J., Chandy, K. G., Garcia, M. L., Gutman, G. A., Martin-Eauclaire, M. F., van der Walt, J. J., and Possani, L. D. (1999) Trends Pharmacol. Sci. 20, 444-447
3. Garcia, M. L., Gao, Y., McManus, O. B., and Kaczorowski, G. J. (2001) Toxicon 39, 739-748
4. Tenenholz, T. C., Klenk, K. C., Matteson, D. R., Blaustein, M. P., and Weber, D. J. (2000) Rev. Physiol. Biochem. Pharmacol. 140, 135-185
5. Korolkova, Y. V., Kozlov, S. A., Lipkin, A. V., Pluzhnikov, K. A., Hadley, J. K., Filippov, A. K., Brown, D. A., Angelo, K., Strøbæk, D., Jespersen, T., Olesen, S. P., Jensen, B. S., and Grishin, E. V. (2001) J. Biol. Chem. 276, 9868-9876
6. Tseng, G. N. (2001) J. Mol. Cell. Cardiol. 33, 835-849
7. Vandenberg, J. I., Walker, B. D., and Campbell, T. J. (2001) Trends Pharmacol. Sci. 22, 240-246
8. Li, H., Fuentes-Garcia, J., and Towbin, J. A. (2000) Pediatr. Cardiol. 21, 542-550
9. Moss, A. J., Zareba, W., Kaufman, E. S., Gartman, E., Peterson, D. R., Benhorin, J., Towbin, J. A., Keating, M. T., Priori, S. G., Schwartz, P. J., Vincent, G. M., Robinson, J. L., Andrews, M. L., Feng, C., Hall, W. J., Medina, A., Zhang, L., and Wang, Z. (2002) Circulation 105, 794-799
10. Roden, D. M., and Balser, J. R. (1999) Cardiovasc. Res. 44, 242-246
11. Plotto, M., Saudek, V., and Sklenar V. (1992) J. Biomol. NMR 2, 661-665
12. Rance, M., Sorensen, O. W., Bodenhausen, G., Wagner, G., Ernst, R. R., and Wutrich, K. (1983) Biochem. Biophys. Res. Commun. 117, 479-485
13. Bax, A., and Davis, D. G. (1985) J. Magn. Res. 65, 355-360
14. Jeener, J., Meier, G. N., Bachman, P., and Ernst, R. R. (1979) J. Chem. Phys. 71, 4546-4553
15. Bartels, C., Xia, T., Billeter, M., Güntert, P., and Wüthrich, K. (1995) J. Biomol. NMR 6, 1-10
16. Güntert, P., Mumenthaler, C., and Wüthrich, K. (1997) J. Mol. Biol. 273, 283-298
17. Jaravine, V. A., Nolde, D. E., Reibarkh, M. J., Korolkova, Y. V., Kozlov, S. A., Pluzhnikov, K. A., Grishin, E. V., and Arseniev A. S. (1997) Biochemistry 36, 1223-1232
18. Baker, E. N., and Hubbard, R. E. (1984) Prog. Biophys. Mol. Biol. 44, 97-179
19. Arseniev, A. S., Kondakov, V. I., Maiorov, V. N., and Bystrov V. F. (1984) FEBS Lett. 165, 57-62
20. Schaumann, T., Braun, W., and Wüthrich, K. (1990) Biopolymers 29, 679-694
21. Koradi, R., Billiter, M., and Wüthrich, K. (1996) J. Mol. Graphics 14, 51-55
22. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291
23. Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K., and Pease, L. R. (1989) Gene (Amst.) 77, 51-59
24. Søgaard, R., Ljungstrom, T., Pedersen, K. A., Olesen, S. P., and Jensen, B. S. (2001) Am. J. Physiol. Cell Physiol. 280, 859-866
25. Sigworth, F. J., Affclter, H., and Neher, E. (1995) J. Neurosci. Methods 56, 203-215
26. Strøbæk, D., Jørgensen, T. D., Christophersen, P., Ahring, P. K., and Olesen, S. P. (2000) Br. J. Pharmacol. 129, 991-999
27. Charles, A. C., Piros, E. T., Evans, C. J., and Hales, T. G. (1999) J. Biol. Chem. 274, 7508-7515
28. Hamill, O. P., Marty, A., Heher, E., Sakmann, B., and Sigworth, F. J. (1981) Pfluegers Arch. 391, 85-100
29. Wüthrich K. (1986) NMR of Proteins and Nucleic Acids, John Wiley & Sons Inc., New York
30. Dyke, T. R., Duggan, B. M., Pennington, M. W., Byrnes, M. E., Kem, W. R. and Norton, R. S. (1996) Biochim. Biophys. Acta 1293, 31-38
31. Dardon, H., Blanc, E., and Sabatier, J.-M. (2000) in Perspective in Drug Discovery and Design (Dardon, H., and Sabatier, J.-M., eds) Vol. 15/16, pp. 41-60, Kluwer, Dordrecht
32. Doyle, D. A., Morais Cabral, J., Pfuetzner, R. A., Kuo, A., Gulbis, J. M., Cohen, S. L., Chait, B. T., and MacKinnon, R. (1998) Science 280, 69-77
33. Rauer, H., Pennington, M., Cahalan, M., and Chandy, K. G. (1999) J. Biol. Chem. 274, 21885-21892
34. Choe, S. (2002) Nat. Rev. Neurosci. 3, 115-121
35. Park, C.-S., and Miller, C. (1992) Neuron 9, 307-313
36. Park, C.-S., and Miller, C. (1992) Biochemistry 31, 7749-7755
37. Ranganathan, R., Lewis, J. H., and MacKinnon, R. (1996) Neuron 16, 131-139
38. Dauplais, M., Lecoq, A., Song, J., Cotton, J., Jamin, N., Gilquin, B., Roumestand, C., Vita, C., de Medeiros, C. L., Rowan, E. G., Harvey, A. L., and Menez, A. (1997) J. Biol. Chem. 272, 4302-4309
39. Gasparini, S., Danse, J. M., Lecoq, A., Pinkasfeld, S., Zinn-Justin, S., Young, L, C., de Medeiros, C. C., Rowan, E. G., Harvey, A. L., and Menez, A. (1998) J. Biol. Chem. 273, 25393-25403
40. Jacobsen, R. B., Koch, E. D., Lange-Malecki, B., Stocker, M., Verhey, J., Van Wagoner, R. M., Vyazovkina, A., Olivera, B. M., and Terlau, H. (2000) J. Biol. Chem. 275, 24639-24644
41. Fan, J.-S., Jiang, M., Dun, W., McDonald, T. V., and Tseng, G.-N. (1999) Biophys. J. 76, 3128-3140
42. Dun, W., Jiang, M., and Tseng, G.-N. (1999) Pfluegers Arch. 439, 141-149
43. Pardo-Lopez, L., Zhang, M., Liu, J., Jiang, M., Possani, L. D., and Tseng, G. N. (2002) J. Biol. Chem. 277, 16403-16411
44. Pardo-Lopez, L., Garcia-Valdes, J., Gurrola, G. B., Robertson, G. A., and Possani, L. D. (2002) FEBS Lett. 510, 45-49