Dissection of the Functional Surface of an Anti-insect Excitatory Toxin Illuminates a Putative "Hot Spot" Common to All Scorpion β-Toxins Affecting Na+ Channels

Journal of Biological Chemistry

Volumn 279, Issue 9, 2004, Pages 8206-8211

  Cohen, Lior ^a   Karbat, Izhar ^a   Gilles, Nicolas ^b   Froy, Oren ^c   Corzo, Gerardo ^b   Angelovici, Ruthie ^a   Gordon, Dalia ^a   Gurevitz, Michael ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b CEA SACLAY   (France)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ELECTRIC POTENTIAL; HYDROPHOBICITY; SOLVENTS; TOXIC MATERIALS; TOXICITY;

CHANNEL GATINGS; TOXIN-RECEPTORS;

BIOCHEMISTRY;

SCORPION BETA TOXIN; SCORPION VENOM; SODIUM CHANNEL; TOXIN; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ALPHA HELIX; ARTICLE; CHANNEL GATING; CIRCULAR DICHROISM; COMPETITIVE INHIBITION; ENZYME SPECIFICITY; HYDROPHOBICITY; MEMBRANE POTENTIAL; NONHUMAN; PATCH CLAMP; PHARMACOPHORE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN MOTIF;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CIRCULAR DICHROISM; INSECT PROTEINS; INSECTICIDES; INSECTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEUROTOXINS; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SCORPIONS; SEQUENCE ALIGNMENT; SODIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP;

HOTTENTOTTA; HOTTENTOTTA JUDAICA; INSECTA; MAMMALIA; SCORPIONES;

EID: 1542289623     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M307531200     Document Type: Article

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