Exploration of the functional site of a scorpion α-like toxin by site-directed mutagenesis

Biochemistry

Volumn 42, Issue 16, 2003, Pages 4699-4708

  Wang, Chun Guang ^a,b   Gilles, Nicolas ^c   Hamon, Alain ^d   Le Gall, Frédéric ^c   Stankiewicz, Maria ^d,e   Pelhate, Marcel ^d   Xiong, Yu Mei ^a,b   Wang, Da Cheng ^b   Chi, Cheng Wu ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b INSTITUTE OF BIOPHYSICS   (China)

^c DIF   (France)

^d UNIVERSITÉ D'ANGERS   (France)

^e NICOLAUS COPERNICUS UNIVERSITY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROPHOBIC CHROMATOGRAPHY; PHARMACODYNAMICS; TOXICITY;

ELECTROPHYSIOLOGICAL RECORDINGS;

TOXIC MATERIALS;

NEUROTOXIN; SCORPION VENOM; SODIUM CHANNEL;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA SHEET; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CIRCULAR DICHROISM; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GENE MUTATION; HYDROPHOBICITY; MALE; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; RECEPTOR BINDING; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; TOXIN ANALYSIS;

ACTION POTENTIALS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; ELECTRIC CONDUCTIVITY; HYDROPHOBICITY; INSECT PROTEINS; INSECTS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEUROTOXINS; PROTEIN STRUCTURE, TERTIARY; SCORPION VENOMS; SEQUENCE ALIGNMENT; SODIUM CHANNELS; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPTOSOMES;

ANIMALIA; BUTHUS; INSECTA; MESOBUTHUS MARTENSII; SCORPIONES;

EID: 0242432359     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0270438     Document Type: Article

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