Importance of the conserved aromatic residues in the scorpion α-like toxin BmK M1. The hydrophobic surface region revisited

Journal of Biological Chemistry

Volumn 278, Issue 26, 2003, Pages 24125-24131

  Sun, Yan Mei ^a   Bosmans, Frank ^a,b   Zhu, Rong Huan ^a   Goudet, Cyril ^b   Xiong, Yu Mei ^a   Tytgat, Jan ^b   Wang, Da Cheng ^a  

^a INSTITUTE OF BIOPHYSICS   (China)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; HYDROPHOBICITY; MOLECULAR STRUCTURE; MUTAGENESIS; TOXICITY; YEAST;

ELECTROPHYSIOLOGY;

AMINO ACIDS;

ALPHA TOXIN; BMK M1 TOXIN; SCORPION VENOM; SODIUM CHANNEL; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BETA SHEET; BIOASSAY; CONTROLLED STUDY; CORRELATION ANALYSIS; ELECTROPHYSIOLOGY; FEMALE; HYDROPHOBICITY; LD 50; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE; SITE DIRECTED MUTAGENESIS; TOXIN STRUCTURE; YEAST CELL;

AMINO ACID SEQUENCE; AMINO ACIDS, AROMATIC; ANIMALS; CIRCULAR DICHROISM; CLONING, MOLECULAR; CONSERVED SEQUENCE; ELECTROPHYSIOLOGY; INSECT PROTEINS; MICE; NEUROTOXINS; OOCYTES; POINT MUTATION; SCORPION VENOMS; SCORPIONS; SODIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

ANIMALIA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE; SCORPIONES;

EID: 0038606006     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M211931200     Document Type: Article

References (27)

1. Couraud, F., Jover, E., Dobois, J. M., and Rochat, H. (1982) Toxicon 20, 9-16
2. Possani, L. D., Becerril, B., Delepierre, M., and Tytgat, J. (1999) Eur. J. Biochem. 264, 287-300
3. Goudet, C., Chi, C., and Tytgat, J. (2002) Toxicon 40, 1239-1258
4. Gordon, D., Martin-Eauclaire, M. F., Cestele, S., Kopeyan, C., Carlier, E., Ben Khalifa, R., Pelhate, M., and Rochat, H. (1996) J. Biol. Chem. 271, 8034-8045
5. Gordon, D., Savarin, P., Gurevitz, M., and Zinn-Justin, S. (1998) J. Toxicol. Toxin Rev. 17, 131-159
6. Housset, D., Habersetzer-Rochat, C., Astier, J. P., and Fontecilla-Camps, J. C. (1994) J. Mol. Biol. 238, 88-103
7. Li, H. M., Wang, D.-C., Zeng, Z. H., Jin, L., and Hu, R. Q. (1996) J. Mol. Biol. 261, 415-431
8. He, X. L., Li, H, M., Zeng, Z. H., Liu, X. Q., Wang, M., and Wang, D.-C. (1999) J. Mol. Biol. 292, 125-135
9. Krimm, I., Gilles, N., Sautiere, P., Stankiewicz, M., Pelhate, M., Gordon, D., and Lancelin, J. M. (1999) J. Mol. Biol. 285, 1749-1763
10. Tugarinov, V., Kustanovich, I., Zilberberg, N., Gurevitz, M., and Anglister, J. (1997) Biochemistry 36, 2414-2424
11. Zilberberg, N., Froy, O., Loret, E., Cestele, S., Arad, D., Gordon, D., and Gurevitz, M. (1997) J. Biol. Chem. 272, 14810-14816
12. Sun, Y.-M., Liu, W., Zhu, R.-H., Goudet, C., Tytgat, J., and Wang, D.-C. (2002) J. Pept. Res. 60, 247-256
13. Goudet, C., Huys, I., Clynen, E., Schoofs, L., Wang, D.-C, Waelkens, E., and Tytgat, J. (2001) FEBS Lett. 495, 61-65
14. Xiong, Y.-M., Ling, M. H., Wang, D.-C., and Chi, C. W. (1997) Toxicon 35, 1025-1031
15. Shao, F., Xiong, Y.-M., Zhu, R.-H., Ling, M. H., Chi, C. W., and Wang, D.-C. (1999) Protein Expression Purif 17, 358-365
16. Li, H. M., Zhao, T., Jin, L., Wang, M., Zhang, Y., and Wang, D.-C. (1999) Acta Crystallogr. Sect. D Biol. Crystallogr. 55, 341-344
17. Fontecilla-Camps, J. C., Habersetzer-Rochat, C., and Rochat, H. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 7443-7447
18. Ito, H., Fukuda, Y., Murata, K., and Kimura, A. (1983) J. Bacteriol. 153, 163-168
19. Meier, J., and Theakston, R. D. G. (1986) Toxicon 24, 395-401
20. Gellens, M. E., George, A. L., Jr., Chen, L. Q., Chahine, M., Horn, R., Barchi, R. L., and Kallen, R. G. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 554-558
21. Liman, E. R., Tytgat, J., and Hess, P. (1992) Neuron 9, 861-871
22. Fontecilla-Camps, J. C., Alamassy, R. J., Suddath, F. L., Watt, D. D., and Bugg, C. E. (1980) Proc. Natl. Acad. Sci. U. S. A. 77, 6496-6500
23. Fontecilla-Camps, J. C., Almassy, R. J., Suddath, F. L., and Bugg, C. E. (1982) Toxicon 20, 1-7
24. Kharrat, R., Darbon, H., Rochat, H., and Granier, C. (1989) Eur. J. Biochem. 181, 381-390
25. Zilberberg, N., Gordon, D., Pelhate, M., Adams, M. E., Norris, T., Zlotkin, E., and Gurevitz, M. (1996) Biochemistry 35, 10215-10222
26. Burley, S. K., and Petsko, G. A. (1988) Adv. Protein Chem. 39, 125-189
27. Koradi, R., Billeter, M., and Wuσthrich, K. (1996) J. Mol. Graphics 14, 51-55