Design and Characterization of a Highly Selective Peptide Inhibitor of the Small Conductance Calcium-activated K+ Channel, SkCa2

Journal of Biological Chemistry

Volumn 276, Issue 46, 2001, Pages 43145-43151

  Shakkottai, Vikram G ^a   Regaya, Imed ^b   Wulff, Heike ^a   Fajloun, Ziad ^b   Tomita, Hiroaki ^a   Fathallah, Mohamed ^b,c   Cahalan, Michael D ^a   Gargus, J Jay ^a   Sabatier, Jean Marc ^b   Chandy, K George ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CNRS   (France)

^c HÔPITAL SAINTE MARGUERITE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROLOGY; TISSUE; TOXICITY;

NEURONS;

BIOCHEMISTRY;

BUTYRIC ACID DERIVATIVE; CALCIUM ACTIVATED POTASSIUM CHANNEL; DIAMINOBUTANOIC ACID; LEIUROTOXIN I; LEIUROTOXIN I DIAMINOBUTANOIC ACID; PO5 TOXIN; POTASSIUM CHANNEL BLOCKING AGENT; PROTEIN INHIBITOR; SKCA2 INHIBITOR; TOXIN; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID; ALANINE; ARGININE; DIAMINOBUTANOYL(7) LEIUROTOXIN I; DIAMINOBUTANOYL(7)-LEIUROTOXIN I; MAUROTOXIN; METHIONINE; NEUROTOXIN; PEPTIDE; PHENYLALANINE; PI1 TOXIN; POTASSIUM CHANNEL; SCORPION VENOM; SCORPION VENOM P05; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; THREONINE; VALINE;

AFTERHYPERPOLARIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL 2; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CELL STRAIN; CELL STRAIN COS1; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; ELECTROPHYSIOLOGY; GENETIC TRANSFECTION; KINETICS; MOLECULAR CLONING; MOLECULAR GENETICS; MUTATION; PROTEIN BINDING; RAT; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

ANIMALIA; MAMMALIA;

ALANINE; AMINO ACID SEQUENCE; ANIMALS; ARGININE; CELL LINE; CLONING, MOLECULAR; COS CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; GAMMA-AMINOBUTYRIC ACID; HUMANS; KINETICS; METHIONINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; NEUROTOXINS; PC12 CELLS; PEPTIDES; PHENYLALANINE; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; PROTEIN BINDING; RATS; SCORPION VENOMS; SEQUENCE HOMOLOGY, AMINO ACID; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; THREONINE; TRANSFECTION; VALINE;

EID: 0035900701     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M106981200     Document Type: Article

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