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Volumn 35, Issue 3, 2005, Pages 187-195

BjαIT: A novel scorpion α-toxin selective for insects - Unique pharmacological tool

Author keywords

Alpha neurotoxins; Black Judean Scorpion; Insect selectivity; Scorpion venom; Voltage Gated Sodium Channels

Indexed keywords

ANDROCTONUS CRASSICAUDA; ANIMALIA; BUTHIDAE; HEXAPODA; HOTTENTOTTA; HOTTENTOTTA JUDAICA; INSECTA; MAMMALIA; SCORPIONES; XENOPUS LAEVIS;

EID: 19944431668     PISSN: 09651748     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ibmb.2004.11.005     Document Type: Article
Times cited : (33)

References (60)
  • 2
    • 0031972937 scopus 로고    scopus 로고
    • A specific interaction between the cardiac sodium channel and site-3 toxin anthopleurin B
    • G.R. Benzinger, J.W. Kyle, K.M. Blumenthal, and D.A. Hanck A specific interaction between the cardiac sodium channel and site-3 toxin anthopleurin B J. Biol. Chem. 273 1 1998 80 84
    • (1998) J. Biol. Chem. , vol.273 , Issue.1 , pp. 80-84
    • Benzinger, G.R.1    Kyle, J.W.2    Blumenthal, K.M.3    Hanck, D.A.4
  • 3
    • 0037021470 scopus 로고    scopus 로고
    • The sea anemone Bunodosoma granulifera contains surprisingly efficacious and potent insect-selective toxins
    • F. Bosmans, A. Aneiros, and J. Tytgat The sea anemone Bunodosoma granulifera contains surprisingly efficacious and potent insect-selective toxins FEBS Lett 532 1-2 2002 131 134
    • (2002) FEBS Lett , vol.532 , Issue.1-2 , pp. 131-134
    • Bosmans, F.1    Aneiros, A.2    Tytgat, J.3
  • 4
    • 0026490286 scopus 로고
    • Cellular and molecular biology of voltage gated sodium channels
    • R.D. Catterall Cellular and molecular biology of voltage gated sodium channels Am. J. Physiol 72 1992 15 48
    • (1992) Am. J. Physiol , vol.72 , pp. 15-48
    • Catterall, R.D.1
  • 5
    • 0033731909 scopus 로고    scopus 로고
    • Molecular mechanisms of neurotoxin action on voltage-gated sodium channels
    • S. Cestele, and W.A. Catterall Molecular mechanisms of neurotoxin action on voltage-gated sodium channels Biochimie 82 9-10 2000 883 892
    • (2000) Biochimie , vol.82 , Issue.9-10 , pp. 883-892
    • Cestele, S.1    Catterall, W.A.2
  • 6
    • 0030611173 scopus 로고    scopus 로고
    • Bot IT2: A new scorpion toxin to study receptor site on insect sodium channels
    • S. Cestele, L. Borchani, M. El Ayeb, and H. Rochat Bot IT2 a new scorpion toxin to study receptor site on insect sodium channels FEBS Lett 405 1 1997 77 80
    • (1997) FEBS Lett , vol.405 , Issue.1 , pp. 77-80
    • Cestele, S.1    Borchani, L.2    El Ayeb, M.3    Rochat, H.4
  • 7
    • 0343488851 scopus 로고    scopus 로고
    • Toxin III from Leiurus quinquestriatus quinquestriatus: A specific probe for receptor site 3 on insect sodium channels
    • S. Cestele, D. Gordon, C. Kopeyan, and H. Rochat Toxin III from Leiurus quinquestriatus quinquestriatus a specific probe for receptor site 3 on insect sodium channels Insect. Biochem. Mol. Biol. 27 6 1997 523 528
    • (1997) Insect. Biochem. Mol. Biol. , vol.27 , Issue.6 , pp. 523-528
    • Cestele, S.1    Gordon, D.2    Kopeyan, C.3    Rochat, H.4
  • 8
    • 0032191111 scopus 로고    scopus 로고
    • Voltage sensor-trapping: Enhanced activation of sodium channels by beta-scorpion toxin bound to the S3-S4 loop in domain II
    • S. Cestele, Y. Qu, J.C. Rogers, H. Rochat, T. Scheuer, and W.A. Catterall Voltage sensor-trapping enhanced activation of sodium channels by beta-scorpion toxin bound to the S3-S4 loop in domain II Neuron 21 4 1998 919 931
    • (1998) Neuron , vol.21 , Issue.4 , pp. 919-931
    • Cestele, S.1    Qu, Y.2    Rogers, J.C.3    Rochat, H.4    Scheuer, T.5    Catterall, W.A.6
  • 10
    • 0023277545 scopus 로고
    • Single step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction
    • P. Chomczynski, and N. Sacci Single step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction Analytical Biochemistry 162 1987 156 159
    • (1987) Analytical Biochemistry , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacci, N.2
  • 11
    • 0000986960 scopus 로고
    • Mechanism of action of scorpion toxins
    • L.W. Chang R.S. Dyer Marcel Dekker New York
    • F. Couraud, and E. Jover Mechanism of action of scorpion toxins L.W. Chang R.S. Dyer Handbook of Natural Toxins 1984 Marcel Dekker New York 659 678
    • (1984) Handbook of Natural Toxins , pp. 659-678
    • Couraud, F.1    Jover, E.2
  • 12
    • 0029001619 scopus 로고
    • Promoter structure and intron-exon organization of a scorpion alpha-toxin gene
    • M.L. Delabre, P. Pasero, M. Marilley, and P.E. Bougis Promoter structure and intron-exon organization of a scorpion alpha-toxin gene Biochemistry 34 20 1995 6729 6736
    • (1995) Biochemistry , vol.34 , Issue.20 , pp. 6729-6736
    • Delabre, M.L.1    Pasero, P.2    Marilley, M.3    Bougis, P.E.4
  • 13
    • 0025303099 scopus 로고
    • A scorpion venom neurotoxin paralytic to insects that affects sodium current inactivation: Purification, primary structure, and mode of action
    • M. Eitan, E. Fowler, R. Herrmann, A. Duval, M. Pelhate, and E. Zlotkin A scorpion venom neurotoxin paralytic to insects that affects sodium current inactivation purification, primary structure, and mode of action Biochemistry 29 25 1990 5941 5947
    • (1990) Biochemistry , vol.29 , Issue.25 , pp. 5941-5947
    • Eitan, M.1    Fowler, E.2    Herrmann, R.3    Duval, A.4    Pelhate, M.5    Zlotkin, E.6
  • 14
    • 0029091192 scopus 로고
    • Cloning and functional analysis of TipE, a novel membrane protein that enhances Drosophila para sodium channel function
    • G. Feng, P. Deak, M. Chopra, and L.M. Hall Cloning and functional analysis of TipE, a novel membrane protein that enhances Drosophila para sodium channel function Cell 82 6 1995 1001 1011
    • (1995) Cell , vol.82 , Issue.6 , pp. 1001-1011
    • Feng, G.1    Deak, P.2    Chopra, M.3    Hall, L.M.4
  • 16
    • 0024094439 scopus 로고
    • Orthorhombic crystals and three-dimensional structure of the potent toxin II from the scorpion Androctonus australis Hector
    • J.C. Fontecilla-Camps, C. Habersetzer-Rochat, and H. Rochat Orthorhombic crystals and three-dimensional structure of the potent toxin II from the scorpion Androctonus australis Hector Proc. Natl. Acad. Sci. USA 85 20 1988 7443 7447
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , Issue.20 , pp. 7443-7447
    • Fontecilla-Camps, J.C.1    Habersetzer-Rochat, C.2    Rochat, H.3
  • 18
    • 0026530472 scopus 로고
    • Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel
    • M.E. Gellens, A.L. George Jr., L.Q. Chen, M. Chahine, R. Horn, R.L. Barchi, and R.G. Kallen Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel Proc. Natl. Acad. Sci. USA 89 2 1992 554 558
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , Issue.2 , pp. 554-558
    • Gellens, M.E.1    George Jr., A.L.2    Chen, L.Q.3    Chahine, M.4    Horn, R.5    Barchi, R.L.6    Kallen, R.G.7
  • 19
    • 0033570298 scopus 로고    scopus 로고
    • A scorpion alpha-like toxin that is active on insects and mammals reveals an unexpected specificity and distribution of sodium channel subtypes in rat brain neurons
    • N. Gilles, C. Blanchet, I. Shichor, M. Zaninetti, I. Lotan, D. Bertrand, and D. Gordon A scorpion alpha-like toxin that is active on insects and mammals reveals an unexpected specificity and distribution of sodium channel subtypes in rat brain neurons J. Neurosci. 19 20 1999 8730 8739
    • (1999) J. Neurosci. , vol.19 , Issue.20 , pp. 8730-8739
    • Gilles, N.1    Blanchet, C.2    Shichor, I.3    Zaninetti, M.4    Lotan, I.5    Bertrand, D.6    Gordon, D.7
  • 21
    • 0031370681 scopus 로고    scopus 로고
    • A new approach to insect-pest control - Combination of neurotoxins interacting with voltage sensitive sodium channels to increase selectivity and specificity
    • D. Gordon A new approach to insect-pest control - combination of neurotoxins interacting with voltage sensitive sodium channels to increase selectivity and specificity Invert. Neurosci. 3 2-3 1997 103 116
    • (1997) Invert. Neurosci. , vol.3 , Issue.2-3 , pp. 103-116
    • Gordon, D.1
  • 22
    • 0037306968 scopus 로고    scopus 로고
    • The selectivity of scorpion alpha-toxins for sodium channel subtypes is determined by subtle variations at the interacting surface
    • D. Gordon, and M. Gurevitz The selectivity of scorpion alpha-toxins for sodium channel subtypes is determined by subtle variations at the interacting surface Toxicon 41 2 2003 125 128
    • (2003) Toxicon , vol.41 , Issue.2 , pp. 125-128
    • Gordon, D.1    Gurevitz, M.2
  • 23
    • 0021682684 scopus 로고
    • The binding of the insect selective neurotoxin (AaIT) from scorpion venom to locust synaptosomal membranes
    • D. Gordon, E. Jover, F. Couraud, and E. Zlotkin The binding of the insect selective neurotoxin (AaIT) from scorpion venom to locust synaptosomal membranes Biochim. Biophys. Acta 778 1984 349 358
    • (1984) Biochim. Biophys. Acta , vol.778 , pp. 349-358
    • Gordon, D.1    Jover, E.2    Couraud, F.3    Zlotkin, E.4
  • 24
    • 0030009637 scopus 로고    scopus 로고
    • Scorpion toxins affecting sodium current inactivation bind to distinct homologous receptor sites on rat brain and insect sodium channels
    • D. Gordon, M.F. Martin-Eauclaire, S. Cestele, C. Kopeyan, E. Carlier, R.B. Khalifa, M. Pelhate, and H. Rochat Scorpion toxins affecting sodium current inactivation bind to distinct homologous receptor sites on rat brain and insect sodium channels J. Biol. Chem. 271 14 1996 8034 8045
    • (1996) J. Biol. Chem. , vol.271 , Issue.14 , pp. 8034-8045
    • Gordon, D.1    Martin-Eauclaire, M.F.2    Cestele, S.3    Kopeyan, C.4    Carlier, E.5    Khalifa, R.B.6    Pelhate, M.7    Rochat, H.8
  • 27
    • 0031473847 scopus 로고    scopus 로고
    • SWISS-MODEL and the Swiss-PdbViewer: An environment for comparative protein modeling
    • N. Guex, and M.C. Peitsch SWISS-MODEL and the Swiss-PdbViewer an environment for comparative protein modeling Electrophoresis 18 15 1997 2714 2723
    • (1997) Electrophoresis , vol.18 , Issue.15 , pp. 2714-2723
    • Guex, N.1    Peitsch, M.C.2
  • 28
    • 0025937530 scopus 로고
    • Nucleotide sequence and structure analysis of a cDNA encoding an alpha insect toxin from the scorpion Leiurus quinquestriatus hebraeus
    • M. Gurevitz, D. Urbach, E. Zlotkin, and N. Zilberberg Nucleotide sequence and structure analysis of a cDNA encoding an alpha insect toxin from the scorpion Leiurus quinquestriatus hebraeus Toxicon 29 10 1991 1270 1272
    • (1991) Toxicon , vol.29 , Issue.10 , pp. 1270-1272
    • Gurevitz, M.1    Urbach, D.2    Zlotkin, E.3    Zilberberg, N.4
  • 29
    • 0022552962 scopus 로고
    • Toxin gamma of the scorpion Tityus serrulatus modifies both activation and inactivation of sodium permeability of nerve membrane
    • P. Jonas, W. Vogel, E.C. Arantes, and J.R. Giglio Toxin gamma of the scorpion Tityus serrulatus modifies both activation and inactivation of sodium permeability of nerve membrane Pflugers. Arch. 407 1 1986 92 99
    • (1986) Pflugers. Arch. , vol.407 , Issue.1 , pp. 92-99
    • Jonas, P.1    Vogel, W.2    Arantes, E.C.3    Giglio, J.R.4
  • 30
    • 0018829595 scopus 로고
    • Binding of scorpion toxins to rat brain synaptosomal fraction. Effects of membrane potential, ions, and other neurotoxins
    • E. Jover, N. Martin-Moutot, F. Couraud, and H. Rochat Binding of scorpion toxins to rat brain synaptosomal fraction. Effects of membrane potential, ions, and other neurotoxins Biochemistry 19 3 1980 463 467
    • (1980) Biochemistry , vol.19 , Issue.3 , pp. 463-467
    • Jover, E.1    Martin-Moutot, N.2    Couraud, F.3    Rochat, H.4
  • 31
    • 0021960313 scopus 로고
    • Primary structure of toxin IV of Leiurus quinquestriatus quinquestriatus: Characterization of a new group of scorpion toxins
    • C. Kopeyan, G. Martinez, and H. Rochat Primary structure of toxin IV of Leiurus quinquestriatus quinquestriatus Characterization of a new group of scorpion toxins FEBS Lett. 181 2 1985 211 217
    • (1985) FEBS Lett. , vol.181 , Issue.2 , pp. 211-217
    • Kopeyan, C.1    Martinez, G.2    Rochat, H.3
  • 32
    • 0025137493 scopus 로고
    • Primary structure of scorpion anti-insect toxins isolated from the venom of Leiurus quinquestriatus quinquestriatus
    • C. Kopeyan, P. Mansuelle, F. Sampieri, T. Brando, E.M. Bahraoui, H. Rochat, and C. Granier Primary structure of scorpion anti-insect toxins isolated from the venom of Leiurus quinquestriatus quinquestriatus FEBS Lett 261 2 1990 423 426
    • (1990) FEBS Lett , vol.261 , Issue.2 , pp. 423-426
    • Kopeyan, C.1    Mansuelle, P.2    Sampieri, F.3    Brando, T.4    Bahraoui, E.M.5    Rochat, H.6    Granier, C.7
  • 33
    • 0027250861 scopus 로고
    • Characterization of toxin III of the scorpion Leiurus quinquestriatus quinquestriatus: A new type of alpha-toxin highly toxic both to mammals and insects
    • C. Kopeyan, P. Mansuelle, M.F. Martin-Eauclaire, H. Rochat, and F. Miranda Characterization of toxin III of the scorpion Leiurus quinquestriatus quinquestriatus a new type of alpha-toxin highly toxic both to mammals and insects Nat. Toxins 1 5 1993 308 312
    • (1993) Nat. Toxins , vol.1 , Issue.5 , pp. 308-312
    • Kopeyan, C.1    Mansuelle, P.2    Martin-Eauclaire, M.F.3    Rochat, H.4    Miranda, F.5
  • 34
    • 0029670286 scopus 로고    scopus 로고
    • 1H-NMR-derived secondary structure and the overall fold of the potent anti-mammal and anti-insect toxin III from the scorpion Leiurus quinquestriatus quinquestriatus
    • C. Landon, B. Cornet, J.M. Bonmatin, C. Kopeyan, H. Rochat, F. Vovelle, and M. Ptak 1H-NMR-derived secondary structure and the overall fold of the potent anti-mammal and anti-insect toxin III from the scorpion Leiurus quinquestriatus quinquestriatus Eur. J. Biochem. 236 2 1996 395 404
    • (1996) Eur. J. Biochem. , vol.236 , Issue.2 , pp. 395-404
    • Landon, C.1    Cornet, B.2    Bonmatin, J.M.3    Kopeyan, C.4    Rochat, H.5    Vovelle, F.6    Ptak, M.7
  • 35
    • 0034073434 scopus 로고    scopus 로고
    • Sodium channels in central neurons of the tobacco budworm, Heliothis virescens: Basic properties and modification by scorpion toxins
    • D. Lee, and M.E. Adams Sodium channels in central neurons of the tobacco budworm, Heliothis virescens basic properties and modification by scorpion toxins J. Insect. Physiol. 46 4 2000 499 508
    • (2000) J. Insect. Physiol. , vol.46 , Issue.4 , pp. 499-508
    • Lee, D.1    Adams, M.E.2
  • 36
    • 0007316181 scopus 로고
    • Purification, characterization and action of two insect toxins from the venom of the scorpion Buthus indiacus
    • D. Lester, P. Lazarovici, M. Pelhate, and E. Zlotkin Purification, characterization and action of two insect toxins from the venom of the scorpion Buthus indiacus Biochim. Biophys. Acta 688 1982 229 236
    • (1982) Biochim. Biophys. Acta , vol.688 , pp. 229-236
    • Lester, D.1    Lazarovici, P.2    Pelhate, M.3    Zlotkin, E.4
  • 37
    • 0026485457 scopus 로고
    • Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs
    • E.R. Liman, J. Tytgat, and P. Hess Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs Neuron 9 5 1992 861 871
    • (1992) Neuron , vol.9 , Issue.5 , pp. 861-871
    • Liman, E.R.1    Tytgat, J.2    Hess, P.3
  • 38
    • 0003017338 scopus 로고
    • Scorpion neurotoxins: Effects and mechanisms
    • L.W. Chang R.S. Dyer Marcel Dekker New York
    • M.F. Martin-Eauclaire, and F. Couraud Scorpion neurotoxins Effects and mechanisms L.W. Chang R.S. Dyer Handbook of neurotoxicology 1995 Marcel Dekker New York 683 716
    • (1995) Handbook of Neurotoxicology , pp. 683-716
    • Martin-Eauclaire, M.F.1    Couraud, F.2
  • 39
    • 0027974873 scopus 로고
    • Variability among insect sodium channels revealed by binding of selective neurotoxins
    • H. Moskowitz, R. Herrmann, E. Zlotkin, and D. Gordon Variability among insect sodium channels revealed by binding of selective neurotoxins Insect. Biochem. Mol. Biol. 224 1994 13 19
    • (1994) Insect. Biochem. Mol. Biol. , vol.224 , pp. 13-19
    • Moskowitz, H.1    Herrmann, R.2    Zlotkin, E.3    Gordon, D.4
  • 41
    • 0020124225 scopus 로고
    • Actions of insect toxin and other toxins derived from the venom of the scorpion Androctonus australis on isolated giant axons of the cockroach (Periplaneta americana)
    • M. Pelhate, and E. Zlotkin Actions of insect toxin and other toxins derived from the venom of the scorpion Androctonus australis on isolated giant axons of the cockroach (Periplaneta americana) J. Exp. Biol. 97 1982 67 77
    • (1982) J. Exp. Biol. , vol.97 , pp. 67-77
    • Pelhate, M.1    Zlotkin, E.2
  • 43
    • 35948934147 scopus 로고
    • The effect of toxins derived from the venom of the scorpion Androctonus australis Hector on beuromuscular transmission
    • P. Rosenberg Pergamon press Oxford
    • W. Rathmayer, M. Ruhland, M. Tintpulver, C. Walther, and E. Zlotkin The effect of toxins derived from the venom of the scorpion Androctonus australis Hector on beuromuscular transmission P. Rosenberg Toxins Animal, Plant and Microbial 1978 Pergamon press Oxford 629 637
    • (1978) Toxins: Animal, Plant and Microbial , pp. 629-637
    • Rathmayer, W.1    Ruhland, M.2    Tintpulver, M.3    Walther, C.4    Zlotkin, E.5
  • 44
    • 33745158157 scopus 로고
    • A simple method of estimating fifty per cent end point
    • L.J. Reed, and S. Muench A simple method of estimating fifty per cent end point Am. J. Hyg. 27 1938 493
    • (1938) Am. J. Hyg. , vol.27 , pp. 493
    • Reed, L.J.1    Muench, S.2
  • 46
    • 0017338845 scopus 로고
    • The effect of toxins from the venom of the scorpion Androctonus australis on a spider nerve-muscle preparation
    • M. Ruhland, E. Zlotkin, and W. Rathmayer The effect of toxins from the venom of the scorpion Androctonus australis on a spider nerve-muscle preparation Toxicon 15 2 1977 157 160
    • (1977) Toxicon , vol.15 , Issue.2 , pp. 157-160
    • Ruhland, M.1    Zlotkin, E.2    Rathmayer, W.3
  • 47
    • 0036618134 scopus 로고    scopus 로고
    • Domain 2 of Drosophila para voltage-gated sodium channel confers insect properties to a rat brain channel
    • I. Shichor, E. Zlotkin, N. Ilan, D. Chikashvili, W. Stuhmer, D. Gordon, and I. Lotan Domain 2 of Drosophila para voltage-gated sodium channel confers insect properties to a rat brain channel J. Neurosci. 22 11 2002 4364 4371
    • (2002) J. Neurosci. , vol.22 , Issue.11 , pp. 4364-4371
    • Shichor, I.1    Zlotkin, E.2    Ilan, N.3    Chikashvili, D.4    Stuhmer, W.5    Gordon, D.6    Lotan, I.7
  • 48
    • 0030023340 scopus 로고    scopus 로고
    • BotIT2, a toxin paralytic to insevts from the Buthus occitanus tunetanus venom modifying the activity of insect sodium channels
    • M. Stankiewicz, F. Grolleau, B. Lapied, L. Borchani, M. El Ayeb, and M. Pelhate BotIT2, a toxin paralytic to insevts from the Buthus occitanus tunetanus venom modifying the activity of insect sodium channels J. Insect. Physiol. 42 4 1996 397 405
    • (1996) J. Insect. Physiol. , vol.42 , Issue.4 , pp. 397-405
    • Stankiewicz, M.1    Grolleau, F.2    Lapied, B.3    Borchani, L.4    El Ayeb, M.5    Pelhate, M.6
  • 49
    • 0038606006 scopus 로고    scopus 로고
    • Importance of the conserved aromatic residues in the scorpion alpha-like toxin BmK M1: The hydrophobic surface region revisited
    • Y.M. Sun, F. Bosmans, R.H. Zhu, C. Goudet, Y.M. Xiong, J. Tytgat, and D.C. Wang Importance of the conserved aromatic residues in the scorpion alpha-like toxin BmK M1 the hydrophobic surface region revisited J. Biol. Chem. 278 26 2003 24125 24131
    • (2003) J. Biol. Chem. , vol.278 , Issue.26 , pp. 24125-24131
    • Sun, Y.M.1    Bosmans, F.2    Zhu, R.H.3    Goudet, C.4    Xiong, Y.M.5    Tytgat, J.6    Wang, D.C.7
  • 50
    • 0032964297 scopus 로고    scopus 로고
    • BLAST 2 Sequences, a new tool for comparing protein and nucleotide sequences
    • T.A. Tatusova, and T.L. Madden BLAST 2 Sequences, a new tool for comparing protein and nucleotide sequences FEMS Microbiol Lett 174 2 1999 247 250
    • (1999) FEMS Microbiol Lett , vol.174 , Issue.2 , pp. 247-250
    • Tatusova, T.A.1    Madden, T.L.2
  • 51
    • 0021275484 scopus 로고
    • The effect of Tityus serrulatus scorpion toxin gamma on Na channels in neuroblastoma cells
    • H.P. Vijverberg, D. Pauron, and M. Lazdunski The effect of Tityus serrulatus scorpion toxin gamma on Na channels in neuroblastoma cells Pflugers. Arch. 401 3 1984 297 303
    • (1984) Pflugers. Arch. , vol.401 , Issue.3 , pp. 297-303
    • Vijverberg, H.P.1    Pauron, D.2    Lazdunski, M.3
  • 53
    • 0025882676 scopus 로고
    • The cDNA sequence of a depressant insect selective neurotoxin from the scorpion Buthotus judaicus
    • N. Zilberberg, E. Zlotkin, and M. Gurevitz The cDNA sequence of a depressant insect selective neurotoxin from the scorpion Buthotus judaicus Toxicon 29 9 1991 1155 1158
    • (1991) Toxicon , vol.29 , Issue.9 , pp. 1155-1158
    • Zilberberg, N.1    Zlotkin, E.2    Gurevitz, M.3
  • 55
    • 0030951334 scopus 로고    scopus 로고
    • Identification of structural elements of a scorpion alpha-neurotoxin important for receptor site recognition
    • N. Zilberberg, O. Froy, E. Loret, S. Cestele, D. Arad, D. Gordon, and M. Gurevitz Identification of structural elements of a scorpion alpha-neurotoxin important for receptor site recognition J. Biol. Chem. 272 23 1997 14810 14816
    • (1997) J. Biol. Chem. , vol.272 , Issue.23 , pp. 14810-14816
    • Zilberberg, N.1    Froy, O.2    Loret, E.3    Cestele, S.4    Arad, D.5    Gordon, D.6    Gurevitz, M.7
  • 56
    • 0033017102 scopus 로고    scopus 로고
    • The insect voltage-gated sodium channel as target of insecticides
    • E. Zlotkin The insect voltage-gated sodium channel as target of insecticides Ann. Rev. Entomol. 44 1999 429 455
    • (1999) Ann. Rev. Entomol. , vol.44 , pp. 429-455
    • Zlotkin, E.1
  • 57
    • 0014980110 scopus 로고
    • A new toxic protein in the venom of the scorpion Androctonus australis Hector
    • E. Zlotkin, F. Miranda, C. Kupeyan, and S. Lissitzky A new toxic protein in the venom of the scorpion Androctonus australis Hector Toxicon 9 1 1971 9 13
    • (1971) Toxicon , vol.9 , Issue.1 , pp. 9-13
    • Zlotkin, E.1    Miranda, F.2    Kupeyan, C.3    Lissitzky, S.4
  • 58
    • 0015197045 scopus 로고
    • Purification and properties of the insect toxin from the venom of the scorpion Androctonus australis Hector
    • E. Zlotkin, H. Rochat, Kopeyan, F. Miranda, and S. Lissitzky Purification and properties of the insect toxin from the venom of the scorpion Androctonus australis Hector Biochimie 53 10 1971 1073 1078
    • (1971) Biochimie , vol.53 , Issue.10 , pp. 1073-1078
    • Zlotkin, E.1    Rochat2    Kopeyan3    Miranda, F.4    Lissitzky, S.5
  • 59
    • 0007320895 scopus 로고
    • Chemistry, specificity and action of arthropod toxic proteins derived from scorpion venoms
    • D.L. Shankland R.M. Holingworth T.J. Smyth
    • E. Zlotkin, W. Rathmayer, and S. Lissitzky Chemistry, specificity and action of arthropod toxic proteins derived from scorpion venoms D.L. Shankland R.M. Holingworth T.J. Smyth Pesticide and venom Neurotoxicity 1978 227 246
    • (1978) Pesticide and Venom Neurotoxicity , pp. 227-246
    • Zlotkin, E.1    Rathmayer, W.2    Lissitzky, S.3
  • 60
    • 0025784813 scopus 로고
    • Functional duality and structural uniqueness of depressant insect-selective neurotoxins
    • E. Zlotkin, M. Eitan, V.P. Bindokas, M.E. Adams, M. Moyer, W. Burkhart, and E. Fowler Functional duality and structural uniqueness of depressant insect-selective neurotoxins Biochemistry 30 19 1991 4814 4821
    • (1991) Biochemistry , vol.30 , Issue.19 , pp. 4814-4821
    • Zlotkin, E.1    Eitan, M.2    Bindokas, V.P.3    Adams, M.E.4    Moyer, M.5    Burkhart, W.6    Fowler, E.7


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