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Volumn 113, Issue 2, 2006, Pages 91-101

The quest for non-invasive delivery of bioactive macromolecules: A focus on heparins

Author keywords

Alternative routes; Bioactive macromolecule; Drug delivery; Heparin; Non invasive

Indexed keywords

BIOCHEMISTRY; DRUG PRODUCTS; MOLECULAR WEIGHT; NANOTECHNOLOGY; PATIENT TREATMENT; PH EFFECTS;

EID: 33745274728     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2006.04.008     Document Type: Review
Times cited : (71)

References (147)
  • 3
    • 0000983222 scopus 로고
    • The thromboplastic action of heparin
    • McLean J. The thromboplastic action of heparin. Am. J. Physiol. 41 (1916) 250-257
    • (1916) Am. J. Physiol. , vol.41 , pp. 250-257
    • McLean, J.1
  • 4
    • 1842608517 scopus 로고    scopus 로고
    • Heparin to pentasaccharide and beyond: the end is not in sight
    • Messmore H.L., Wehrmacher W.H., Coyne E., and Fareed J. Heparin to pentasaccharide and beyond: the end is not in sight. Semin. Thromb. Hemost. 30 Suppl 1 (2004) 81-88
    • (2004) Semin. Thromb. Hemost. , vol.30 , Issue.SUPPL. 1 , pp. 81-88
    • Messmore, H.L.1    Wehrmacher, W.H.2    Coyne, E.3    Fareed, J.4
  • 5
    • 0036463453 scopus 로고    scopus 로고
    • Novel drug development opportunities for heparin
    • Lever R., and Page C.P. Novel drug development opportunities for heparin. Nat. Rev. Drug Discov. 1 2 (2002) 140-148
    • (2002) Nat. Rev. Drug Discov. , vol.1 , Issue.2 , pp. 140-148
    • Lever, R.1    Page, C.P.2
  • 7
    • 21744442224 scopus 로고    scopus 로고
    • Gastrointestinal absorption of heparin by lipidization or coadministration with penetration enhancers
    • Ross B.P., and Toth I. Gastrointestinal absorption of heparin by lipidization or coadministration with penetration enhancers. Curr. Drug Deliv. 2 3 (2005) 277-287
    • (2005) Curr. Drug Deliv. , vol.2 , Issue.3 , pp. 277-287
    • Ross, B.P.1    Toth, I.2
  • 8
    • 2942667700 scopus 로고    scopus 로고
    • Oral delivery of heparin: SNAC and related formulations
    • Pineo G., Hull R., and Marder V. Oral delivery of heparin: SNAC and related formulations. Best Pract. Res. Clin. Haematol. 17 1 (2004) 153-160
    • (2004) Best Pract. Res. Clin. Haematol. , vol.17 , Issue.1 , pp. 153-160
    • Pineo, G.1    Hull, R.2    Marder, V.3
  • 9
    • 0036204925 scopus 로고    scopus 로고
    • Oral heparins
    • Hiebert L.M. Oral heparins. Clin. Lab. 48 3-4 (2002) 111-116
    • (2002) Clin. Lab. , vol.48 , Issue.3-4 , pp. 111-116
    • Hiebert, L.M.1
  • 10
    • 0003409027 scopus 로고
    • An investigation of routes of administration of heparin other than injection
    • Windsor E., and Freeman L. An investigation of routes of administration of heparin other than injection. Am. J. Med. 37 (1964) 408-416
    • (1964) Am. J. Med. , vol.37 , pp. 408-416
    • Windsor, E.1    Freeman, L.2
  • 11
    • 4544226466 scopus 로고    scopus 로고
    • New anticoagulants for treatment of venous thromboembolism
    • Weitz J.I. New anticoagulants for treatment of venous thromboembolism. Circulation 110 9 Suppl 1 (2004) I19-I26
    • (2004) Circulation , vol.110 , Issue.9 SUPPL. 1
    • Weitz, J.I.1
  • 12
    • 17644379907 scopus 로고    scopus 로고
    • Antithrombotic therapy during percutaneous coronary interventions
    • Verheugt F.W., Dieker H., and Aengevaeren W.R. Antithrombotic therapy during percutaneous coronary interventions. Ned. Tijdschr. Geneeskd. 149 17 (2005) 912-916
    • (2005) Ned. Tijdschr. Geneeskd. , vol.149 , Issue.17 , pp. 912-916
    • Verheugt, F.W.1    Dieker, H.2    Aengevaeren, W.R.3
  • 13
    • 2442545479 scopus 로고    scopus 로고
    • The use of bivalirudin to prevent subacute thrombosis during drug-eluting stent implantation
    • Medina R.P., and Foto D. The use of bivalirudin to prevent subacute thrombosis during drug-eluting stent implantation. J. Invasive Cardiol. 16 5 (2004) 236-239
    • (2004) J. Invasive Cardiol. , vol.16 , Issue.5 , pp. 236-239
    • Medina, R.P.1    Foto, D.2
  • 15
    • 1242339648 scopus 로고    scopus 로고
    • Percutaneous coronary intervention in diabetic patients with non-ST-segment elevation acute coronary syndromes
    • Roffi M., and Topol E.J. Percutaneous coronary intervention in diabetic patients with non-ST-segment elevation acute coronary syndromes. Eur. Heart. J. 25 3 (2004) 190-198
    • (2004) Eur. Heart. J. , vol.25 , Issue.3 , pp. 190-198
    • Roffi, M.1    Topol, E.J.2
  • 16
    • 20444402267 scopus 로고    scopus 로고
    • Heparin-loaded zein microsphere film and hemocompatibility
    • Wang H.J., Lin Z.X., Liu X.M., Sheng S.Y., and Wang J.Y. Heparin-loaded zein microsphere film and hemocompatibility. J. Control. Release 105 1-2 (2005) 120-131
    • (2005) J. Control. Release , vol.105 , Issue.1-2 , pp. 120-131
    • Wang, H.J.1    Lin, Z.X.2    Liu, X.M.3    Sheng, S.Y.4    Wang, J.Y.5
  • 18
    • 0035979396 scopus 로고    scopus 로고
    • Physiological transport forces govern drug distribution for stent-based delivery
    • Hwang C.W., Wu D., and Edelman E.R. Physiological transport forces govern drug distribution for stent-based delivery. Circulation 104 5 (2001) 600-605
    • (2001) Circulation , vol.104 , Issue.5 , pp. 600-605
    • Hwang, C.W.1    Wu, D.2    Edelman, E.R.3
  • 19
    • 4043177078 scopus 로고    scopus 로고
    • Targeted delivery of heparin and LMWH using a fibrin antibody prevents restenosis
    • Thomas A.C., and Campbell J.H. Targeted delivery of heparin and LMWH using a fibrin antibody prevents restenosis. Atherosclerosis 176 1 (2004) 73-81
    • (2004) Atherosclerosis , vol.176 , Issue.1 , pp. 73-81
    • Thomas, A.C.1    Campbell, J.H.2
  • 20
    • 0037428958 scopus 로고    scopus 로고
    • ATTEMPTS: a heparin/protamine-based triggered release system for the delivery of enzyme drugs without associated side-effects
    • Park Y.J., Liang J.F., Song H., Li Y.T., Naik S., and Yang V.C. ATTEMPTS: a heparin/protamine-based triggered release system for the delivery of enzyme drugs without associated side-effects. Adv. Drug Deliv. Rev. 55 2 (2003) 251-265
    • (2003) Adv. Drug Deliv. Rev. , vol.55 , Issue.2 , pp. 251-265
    • Park, Y.J.1    Liang, J.F.2    Song, H.3    Li, Y.T.4    Naik, S.5    Yang, V.C.6
  • 21
    • 0029936713 scopus 로고    scopus 로고
    • Low-molecular-weight heparin-an opportunity for home treatment of venous thrombosis
    • Schafer A.I. Low-molecular-weight heparin-an opportunity for home treatment of venous thrombosis. N. Engl. J. Med. 334 11 (1996) 724-725
    • (1996) N. Engl. J. Med. , vol.334 , Issue.11 , pp. 724-725
    • Schafer, A.I.1
  • 23
    • 0033844117 scopus 로고    scopus 로고
    • Purification and characterization of a novel heparinase from Bacteroides stercoris HJ-15
    • Kim B.T., Kim W.S., Kim Y.S., Linhardt R.J., and Kim D.H. Purification and characterization of a novel heparinase from Bacteroides stercoris HJ-15. J. Biochem. (Tokyo) 128 2 (2000) 323-328
    • (2000) J. Biochem. (Tokyo) , vol.128 , Issue.2 , pp. 323-328
    • Kim, B.T.1    Kim, W.S.2    Kim, Y.S.3    Linhardt, R.J.4    Kim, D.H.5
  • 24
    • 0031815528 scopus 로고    scopus 로고
    • Characterization of a Bacteroides species from human intestine that degrades glycosaminoglycans
    • Ahn M.Y., Shin K.H., Kim D.H., Jung E.A., Toida T., Linhardt R.J., and Kim Y.S. Characterization of a Bacteroides species from human intestine that degrades glycosaminoglycans. Can. J. Microbiol. 44 5 (1998) 423-429
    • (1998) Can. J. Microbiol. , vol.44 , Issue.5 , pp. 423-429
    • Ahn, M.Y.1    Shin, K.H.2    Kim, D.H.3    Jung, E.A.4    Toida, T.5    Linhardt, R.J.6    Kim, Y.S.7
  • 26
    • 0024562085 scopus 로고
    • Resistance of heparinase-derived heparin fragments to biotransformation
    • Larsen A.K., Rice K.G., Linhardt R.J., Wogan G., and Langer R. Resistance of heparinase-derived heparin fragments to biotransformation. J. Biol. Chem. 264 3 (1989) 1570-1577
    • (1989) J. Biol. Chem. , vol.264 , Issue.3 , pp. 1570-1577
    • Larsen, A.K.1    Rice, K.G.2    Linhardt, R.J.3    Wogan, G.4    Langer, R.5
  • 27
    • 0023945212 scopus 로고
    • Effects of N-deacetylation and N-desulfation of heparin on its anticoagulant activity and in vivo disposition
    • Bjornsson T.D., Schneider D.E., and Hecht A.R. Effects of N-deacetylation and N-desulfation of heparin on its anticoagulant activity and in vivo disposition. J. Pharmacol. Exp. Ther. 245 3 (1988) 804-808
    • (1988) J. Pharmacol. Exp. Ther. , vol.245 , Issue.3 , pp. 804-808
    • Bjornsson, T.D.1    Schneider, D.E.2    Hecht, A.R.3
  • 28
    • 0037393955 scopus 로고    scopus 로고
    • Challenges for the oral delivery of macromolecules
    • Goldberg M., and Gomez-Orellana I. Challenges for the oral delivery of macromolecules. Nat. Rev. Drug Discov. 2 4 (2003) 289-295
    • (2003) Nat. Rev. Drug Discov. , vol.2 , Issue.4 , pp. 289-295
    • Goldberg, M.1    Gomez-Orellana, I.2
  • 29
    • 0027264167 scopus 로고
    • The heparin target organ-the endothelium. Studies in a rat model
    • Hiebert L.M., Wice S.M., McDuffie N.M., and Jaques L.B. The heparin target organ-the endothelium. Studies in a rat model. Q. J. Med. 86 5 (1993) 341-348
    • (1993) Q. J. Med. , vol.86 , Issue.5 , pp. 341-348
    • Hiebert, L.M.1    Wice, S.M.2    McDuffie, N.M.3    Jaques, L.B.4
  • 30
    • 0030048879 scopus 로고    scopus 로고
    • Tissue average binding and equilibrium distribution: an example with heparin in arterial tissues
    • Lovich M.A., and Edelman E.R. Tissue average binding and equilibrium distribution: an example with heparin in arterial tissues. Biophys. J. 70 3 (1996) 1553-1559
    • (1996) Biophys. J. , vol.70 , Issue.3 , pp. 1553-1559
    • Lovich, M.A.1    Edelman, E.R.2
  • 31
    • 0035019608 scopus 로고    scopus 로고
    • Delivery of bioactive peptides and proteins across oral (buccal) mucosa
    • Senel S., Kremer M., Nagy K., and Squier C. Delivery of bioactive peptides and proteins across oral (buccal) mucosa. Curr. Pharm. Biotechnol. 2 2 (2001) 175-186
    • (2001) Curr. Pharm. Biotechnol. , vol.2 , Issue.2 , pp. 175-186
    • Senel, S.1    Kremer, M.2    Nagy, K.3    Squier, C.4
  • 33
    • 33745227494 scopus 로고
    • Sublingual heparin in hyperlipemia; a preliminary report
    • Fuller H.L. Sublingual heparin in hyperlipemia; a preliminary report. Angiology 9 5 (1958) 311-313
    • (1958) Angiology , vol.9 , Issue.5 , pp. 311-313
    • Fuller, H.L.1
  • 35
    • 33745256840 scopus 로고
    • Kardiologiia 8 7 (1968) 50-53
    • (1968) Kardiologiia , vol.8 , Issue.7 , pp. 50-53
  • 36
    • 33745274879 scopus 로고
    • Sublingual administration of heparin
    • Kalliomaki L. Sublingual administration of heparin. Duodecim 68 7-8 (1952) 655-658
    • (1952) Duodecim , vol.68 , Issue.7-8 , pp. 655-658
    • Kalliomaki, L.1
  • 37
    • 33745261898 scopus 로고
    • Buccal and sublingual administration of heparin potassium (clarin); studies of plasma triglyceride lipolysis and heparin levels
    • Engelberg H. Buccal and sublingual administration of heparin potassium (clarin); studies of plasma triglyceride lipolysis and heparin levels. J. Am. Med. Assoc. 169 12 (1959) 1322-1325
    • (1959) J. Am. Med. Assoc. , vol.169 , Issue.12 , pp. 1322-1325
    • Engelberg, H.1
  • 38
    • 33745265343 scopus 로고
    • Ineffectiveness of heparin by sublingual administration
    • McDevitt E., Huebner R.D., and Wright I.S. Ineffectiveness of heparin by sublingual administration. J. Am. Med. Assoc. 148 13 (1952) 1123-1124
    • (1952) J. Am. Med. Assoc. , vol.148 , Issue.13 , pp. 1123-1124
    • McDevitt, E.1    Huebner, R.D.2    Wright, I.S.3
  • 39
    • 33745279859 scopus 로고
    • An evaluation of anticoagulant therapy
    • Wright I.S. An evaluation of anticoagulant therapy. Am. J. Med. 14 6 (1953) 720-730
    • (1953) Am. J. Med. , vol.14 , Issue.6 , pp. 720-730
    • Wright, I.S.1
  • 40
    • 0021947991 scopus 로고
    • Low molecular weight heparin-like preparations with oral activity
    • Lasker S.E. Low molecular weight heparin-like preparations with oral activity. Semin. Thromb. Hemost. 11 1 (1985) 37-39
    • (1985) Semin. Thromb. Hemost. , vol.11 , Issue.1 , pp. 37-39
    • Lasker, S.E.1
  • 41
    • 0020572581 scopus 로고
    • Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone
    • Folkman J., Langer R., Linhardt R.J., Haudenschild C., and Taylor S. Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone. Science 221 4612 (1983) 719-725
    • (1983) Science , vol.221 , Issue.4612 , pp. 719-725
    • Folkman, J.1    Langer, R.2    Linhardt, R.J.3    Haudenschild, C.4    Taylor, S.5
  • 43
    • 20344385254 scopus 로고    scopus 로고
    • Oral heparin delivery: design and in vivo evaluation of a stomach-targeted mucoadhesive delivery system
    • Schmitz T., Leitner V.M., and Bernkop-Schnurch A. Oral heparin delivery: design and in vivo evaluation of a stomach-targeted mucoadhesive delivery system. J. Pharm. Sci. 94 5 (2005) 966-973
    • (2005) J. Pharm. Sci. , vol.94 , Issue.5 , pp. 966-973
    • Schmitz, T.1    Leitner, V.M.2    Bernkop-Schnurch, A.3
  • 44
    • 0022474258 scopus 로고
    • Oral heparin results in the appearance of heparin fragments in the plasma of rats
    • Larsen A.K., Lund D.P., Langer R., and Folkman J. Oral heparin results in the appearance of heparin fragments in the plasma of rats. Proc. Natl. Acad. Sci. U. S. A. 83 9 (1986) 2964-2968
    • (1986) Proc. Natl. Acad. Sci. U. S. A. , vol.83 , Issue.9 , pp. 2964-2968
    • Larsen, A.K.1    Lund, D.P.2    Langer, R.3    Folkman, J.4
  • 45
    • 0001502515 scopus 로고
    • Gastrointestinal absorption of heparin and synthetic heparinoids
    • Windsor E., and Cronheim G.E. Gastrointestinal absorption of heparin and synthetic heparinoids. Naturwissenschaften 190 (1961) 263-264
    • (1961) Naturwissenschaften , vol.190 , pp. 263-264
    • Windsor, E.1    Cronheim, G.E.2
  • 46
    • 0014608894 scopus 로고
    • Intestinal absorption of heparin: a study of the interactions of components of oil-in-water emulsions
    • Engel R.H., and Riggi S.J. Intestinal absorption of heparin: a study of the interactions of components of oil-in-water emulsions. J. Pharm. Sci. 58 11 (1969) 1372-1375
    • (1969) J. Pharm. Sci. , vol.58 , Issue.11 , pp. 1372-1375
    • Engel, R.H.1    Riggi, S.J.2
  • 47
    • 0026561010 scopus 로고
    • Oral heparin normalizes blood pressure and elevated cytosolic calcium in hypertensive rats
    • Vasdev S., Sampson C.A., Longerich L., Prabhakaran V.M., and Parai S. Oral heparin normalizes blood pressure and elevated cytosolic calcium in hypertensive rats. Artery 19 3 (1992) 124-146
    • (1992) Artery , vol.19 , Issue.3 , pp. 124-146
    • Vasdev, S.1    Sampson, C.A.2    Longerich, L.3    Prabhakaran, V.M.4    Parai, S.5
  • 48
    • 0031422605 scopus 로고    scopus 로고
    • Heparin absorption across the intestine: effects of sodium N-[8-(2-hydroxybenzoyl)amino]caprylate in rat in situ intestinal instillations and in Caco-2 monolayers
    • Brayden D., Creed E., O'Connell A., Leipold H., Agarwal R., and Leone-Bay A. Heparin absorption across the intestine: effects of sodium N-[8-(2-hydroxybenzoyl)amino]caprylate in rat in situ intestinal instillations and in Caco-2 monolayers. Pharm. Res. 14 12 (1997) 1772-1779
    • (1997) Pharm. Res. , vol.14 , Issue.12 , pp. 1772-1779
    • Brayden, D.1    Creed, E.2    O'Connell, A.3    Leipold, H.4    Agarwal, R.5    Leone-Bay, A.6
  • 50
    • 0029952488 scopus 로고    scopus 로고
    • Antithrombotic activity of oral unfractionated heparin
    • Hiebert L.M., Wice S.M., and Jaques L.B. Antithrombotic activity of oral unfractionated heparin. J. Cardiovasc. Pharmacol. 28 1 (1996) 26-29
    • (1996) J. Cardiovasc. Pharmacol. , vol.28 , Issue.1 , pp. 26-29
    • Hiebert, L.M.1    Wice, S.M.2    Jaques, L.B.3
  • 51
    • 0034617433 scopus 로고    scopus 로고
    • Intragastric administration of heparin enhances gastric ulcer healing through a nitric oxide-dependent mechanism in rats
    • Li Y., Wang W.P., Wang H.Y., and Cho C.H. Intragastric administration of heparin enhances gastric ulcer healing through a nitric oxide-dependent mechanism in rats. Eur. J. Pharmacol. 399 2-3 (2000) 205-214
    • (2000) Eur. J. Pharmacol. , vol.399 , Issue.2-3 , pp. 205-214
    • Li, Y.1    Wang, W.P.2    Wang, H.Y.3    Cho, C.H.4
  • 52
    • 0033952724 scopus 로고    scopus 로고
    • Absorption and antithrombotic activity of unfractioned heparin after intraduodenal administration in rats
    • Costantini V., Deveglia R., Stabile A., and Nenci G.G. Absorption and antithrombotic activity of unfractioned heparin after intraduodenal administration in rats. Blood Coagul. Fibrinolysis 11 1 (2000) 7-13
    • (2000) Blood Coagul. Fibrinolysis , vol.11 , Issue.1 , pp. 7-13
    • Costantini, V.1    Deveglia, R.2    Stabile, A.3    Nenci, G.G.4
  • 53
    • 0038015493 scopus 로고    scopus 로고
    • Development and in vivo evaluation of an oral delivery system for low molecular weight heparin based on thiolated polycarbophil
    • Kast C.E., Guggi D., Langoth N., and Bernkop-Schnurch A. Development and in vivo evaluation of an oral delivery system for low molecular weight heparin based on thiolated polycarbophil. Pharm. Res. 20 6 (2003) 931-936
    • (2003) Pharm. Res. , vol.20 , Issue.6 , pp. 931-936
    • Kast, C.E.1    Guggi, D.2    Langoth, N.3    Bernkop-Schnurch, A.4
  • 54
    • 0034748293 scopus 로고    scopus 로고
    • Enhancement of the intestinal absorption of low molecular weight heparin (LMWH) in rats and pigs using Carbopol 934P
    • Thanou M., Verhoef J.C., Nihot M.T., Verheijden J.H., and Junginger H.E. Enhancement of the intestinal absorption of low molecular weight heparin (LMWH) in rats and pigs using Carbopol 934P. Pharm. Res. 18 11 (2001) 1638-1641
    • (2001) Pharm. Res. , vol.18 , Issue.11 , pp. 1638-1641
    • Thanou, M.1    Verhoef, J.C.2    Nihot, M.T.3    Verheijden, J.H.4    Junginger, H.E.5
  • 55
    • 14644424682 scopus 로고    scopus 로고
    • Tetradecylmaltoside (TDM) enhances in vitro and in vivo intestinal absorption of enoxaparin, a low molecular weight heparin
    • Yang T., Arnold J.J., and Ahsan F. Tetradecylmaltoside (TDM) enhances in vitro and in vivo intestinal absorption of enoxaparin, a low molecular weight heparin. J. Drug Target. 13 1 (2005) 29-38
    • (2005) J. Drug Target. , vol.13 , Issue.1 , pp. 29-38
    • Yang, T.1    Arnold, J.J.2    Ahsan, F.3
  • 56
    • 30844439844 scopus 로고    scopus 로고
    • Oral delivery of low-molecular-weight heparin using sodium caprate as absorption enhancer reaches therapeutic levels
    • Motlekar N.A., Srivenugopal K.S., Wachtel M.S., and Youan B.B. Oral delivery of low-molecular-weight heparin using sodium caprate as absorption enhancer reaches therapeutic levels. J. Drug Target. 13 10 (2005) 573-583
    • (2005) J. Drug Target. , vol.13 , Issue.10 , pp. 573-583
    • Motlekar, N.A.1    Srivenugopal, K.S.2    Wachtel, M.S.3    Youan, B.B.4
  • 59
    • 0035910111 scopus 로고    scopus 로고
    • Oral heparin prevents neointimal hyperplasia after arterial injury: inhibitory potential depends on type of vascular injury
    • Welt F.G., Woods T.C., and Edelman E.R. Oral heparin prevents neointimal hyperplasia after arterial injury: inhibitory potential depends on type of vascular injury. Circulation 104 25 (2001) 3121-3124
    • (2001) Circulation , vol.104 , Issue.25 , pp. 3121-3124
    • Welt, F.G.1    Woods, T.C.2    Edelman, E.R.3
  • 60
    • 0020383837 scopus 로고
    • Oral administration of liposomally-entrapped heparin to beagle dogs
    • Ueno M., Nakasaki T., Horikoshi I., and Sakuragawa N. Oral administration of liposomally-entrapped heparin to beagle dogs. Chem. Pharm. Bull. (Tokyo) 30 6 (1982) 2245-2247
    • (1982) Chem. Pharm. Bull. (Tokyo) , vol.30 , Issue.6 , pp. 2245-2247
    • Ueno, M.1    Nakasaki, T.2    Horikoshi, I.3    Sakuragawa, N.4
  • 61
    • 0024338219 scopus 로고
    • Investigations on plasma activity of low molecular weight heparin after intravenous and oral administrations
    • Dryjski M., Schneider D.E., Mojaverian P., Kuo B.S., and Bjornsson T.D. Investigations on plasma activity of low molecular weight heparin after intravenous and oral administrations. Br. J. Clin. Pharmacol. 28 2 (1989) 188-192
    • (1989) Br. J. Clin. Pharmacol. , vol.28 , Issue.2 , pp. 188-192
    • Dryjski, M.1    Schneider, D.E.2    Mojaverian, P.3    Kuo, B.S.4    Bjornsson, T.D.5
  • 64
    • 0000477658 scopus 로고    scopus 로고
    • Treatment of corticosteroid-resistant ulcerative colitis with oral low molecular weight heparin
    • Cui H.F., and Jiang X.L. Treatment of corticosteroid-resistant ulcerative colitis with oral low molecular weight heparin. World J. Gastroenterol. 5 5 (1999) 448-450
    • (1999) World J. Gastroenterol. , vol.5 , Issue.5 , pp. 448-450
    • Cui, H.F.1    Jiang, X.L.2
  • 65
    • 15944426155 scopus 로고    scopus 로고
    • Increased plasma anti-Xa activity and recovery of heparin from urine suggest absorption of orally administered unfractionated heparin in human subjects
    • Hiebert L.M., Wice S.M., and Ping T. Increased plasma anti-Xa activity and recovery of heparin from urine suggest absorption of orally administered unfractionated heparin in human subjects. J. Lab. Clin. Med. 145 3 (2005) 151-155
    • (2005) J. Lab. Clin. Med. , vol.145 , Issue.3 , pp. 151-155
    • Hiebert, L.M.1    Wice, S.M.2    Ping, T.3
  • 66
    • 1842760484 scopus 로고    scopus 로고
    • Oral heparin administration with a novel drug delivery agent (SNAC) in healthy volunteers and patients undergoing elective total hip arthroplasty
    • Berkowitz S.D., Marder V.J., Kosutic G., and Baughman R.A. Oral heparin administration with a novel drug delivery agent (SNAC) in healthy volunteers and patients undergoing elective total hip arthroplasty. J. Thromb. Haemost. 1 9 (2003) 1914-1919
    • (2003) J. Thromb. Haemost. , vol.1 , Issue.9 , pp. 1914-1919
    • Berkowitz, S.D.1    Marder, V.J.2    Kosutic, G.3    Baughman, R.A.4
  • 67
    • 32044444307 scopus 로고    scopus 로고
    • Oral delivery of chemical conjugates of heparin and deoxycholic acid in aqueous formulation
    • Kim S.K., Vaishali B., Lee E., Lee S., Lee Y.K., Kumar T.S., Moon H.T., and Byun Y. Oral delivery of chemical conjugates of heparin and deoxycholic acid in aqueous formulation. Thromb. Res. 117 4 (2005) 419-427
    • (2005) Thromb. Res. , vol.117 , Issue.4 , pp. 419-427
    • Kim, S.K.1    Vaishali, B.2    Lee, E.3    Lee, S.4    Lee, Y.K.5    Kumar, T.S.6    Moon, H.T.7    Byun, Y.8
  • 68
    • 0035910004 scopus 로고    scopus 로고
    • Conjugation of low-molecular-weight heparin and deoxycholic acid for the development of a new oral anticoagulant agent
    • Lee Y., Nam J.H., Shin H.C., and Byun Y. Conjugation of low-molecular-weight heparin and deoxycholic acid for the development of a new oral anticoagulant agent. Circulation 104 25 (2001) 3116-3120
    • (2001) Circulation , vol.104 , Issue.25 , pp. 3116-3120
    • Lee, Y.1    Nam, J.H.2    Shin, H.C.3    Byun, Y.4
  • 69
    • 11144247937 scopus 로고    scopus 로고
    • Preparation and characterization of self-assembled nanoparticles of heparin-deoxycholic acid conjugates
    • Park K., Kim K., Kwon I.C., Kim S.K., Lee S., Lee D.Y., and Byun Y. Preparation and characterization of self-assembled nanoparticles of heparin-deoxycholic acid conjugates. Langmuir 20 26 (2004) 11726-11731
    • (2004) Langmuir , vol.20 , Issue.26 , pp. 11726-11731
    • Park, K.1    Kim, K.2    Kwon, I.C.3    Kim, S.K.4    Lee, S.5    Lee, D.Y.6    Byun, Y.7
  • 70
    • 27744527586 scopus 로고    scopus 로고
    • Polycationic lipophilic-core dendrons as penetration enhancers for the oral administration of low molecular weight heparin
    • Hayes P.Y., Ross B.P., Thomas B.G., and Toth I. Polycationic lipophilic-core dendrons as penetration enhancers for the oral administration of low molecular weight heparin. Bioorg. Med. Chem. 14 1 (2006) 143-152
    • (2006) Bioorg. Med. Chem. , vol.14 , Issue.1 , pp. 143-152
    • Hayes, P.Y.1    Ross, B.P.2    Thomas, B.G.3    Toth, I.4
  • 71
    • 1142309794 scopus 로고    scopus 로고
    • In situ intestinal absorption studies on low molecular weight heparin in rats using labrasol as absorption enhancer
    • Rama Prasad Y.V., Minamimoto T., Yoshikawa Y., Shibata N., Mori S., Matsuura A., and Takada K. In situ intestinal absorption studies on low molecular weight heparin in rats using labrasol as absorption enhancer. Int. J. Pharm. 271 1-2 (2004) 225-232
    • (2004) Int. J. Pharm. , vol.271 , Issue.1-2 , pp. 225-232
    • Rama Prasad, Y.V.1    Minamimoto, T.2    Yoshikawa, Y.3    Shibata, N.4    Mori, S.5    Matsuura, A.6    Takada, K.7
  • 72
    • 0014483190 scopus 로고
    • Effect of sulfated and sulfonated surfactants on the intestinal absorption of heparin
    • Engel R.H., and Riggi S.J. Effect of sulfated and sulfonated surfactants on the intestinal absorption of heparin. Proc. Soc. Exp. Biol. Med. 130 3 (1969) 879-884
    • (1969) Proc. Soc. Exp. Biol. Med. , vol.130 , Issue.3 , pp. 879-884
    • Engel, R.H.1    Riggi, S.J.2
  • 73
    • 4143053457 scopus 로고    scopus 로고
    • Enhancement of heparin and heparin disaccharide absorption by the Phytolacca americana saponins
    • Cho S.Y., Sim J.S., Kang S.S., Jeong C.S., Linhardt R.J., and Kim Y.S. Enhancement of heparin and heparin disaccharide absorption by the Phytolacca americana saponins. Arch. Pharm. Res. 26 12 (2003) 1102-1108
    • (2003) Arch. Pharm. Res. , vol.26 , Issue.12 , pp. 1102-1108
    • Cho, S.Y.1    Sim, J.S.2    Kang, S.S.3    Jeong, C.S.4    Linhardt, R.J.5    Kim, Y.S.6
  • 74
    • 0035171635 scopus 로고    scopus 로고
    • Mono-N-carboxymethyl chitosan (MCC), a polyampholytic chitosan derivative, enhances the intestinal absorption of low molecular weight heparin across intestinal epithelia in vitro and in vivo
    • Thanou M., Nihot M.T., Jansen M., Verhoef J.C., and Junginger H.E. Mono-N-carboxymethyl chitosan (MCC), a polyampholytic chitosan derivative, enhances the intestinal absorption of low molecular weight heparin across intestinal epithelia in vitro and in vivo. J. Pharm. Sci. 90 1 (2001) 38-46
    • (2001) J. Pharm. Sci. , vol.90 , Issue.1 , pp. 38-46
    • Thanou, M.1    Nihot, M.T.2    Jansen, M.3    Verhoef, J.C.4    Junginger, H.E.5
  • 75
    • 0038460837 scopus 로고    scopus 로고
    • Thiolated polymers-thiomers: synthesis and in vitro evaluation of chitosan-2-iminothiolane conjugates
    • Bernkop-Schnurch A., Hornof M., and Zoidl T. Thiolated polymers-thiomers: synthesis and in vitro evaluation of chitosan-2-iminothiolane conjugates. Int. J. Pharm. 260 2 (2003) 229-237
    • (2003) Int. J. Pharm. , vol.260 , Issue.2 , pp. 229-237
    • Bernkop-Schnurch, A.1    Hornof, M.2    Zoidl, T.3
  • 76
    • 33745284758 scopus 로고    scopus 로고
    • N. Motlekar, A. Fasano, M. Wachtel, B.B. Youan, Zonula occludens toxin synthetic peptide derivative AT1002 enhances in vitro and in vivo intestinal absorption of low-molecular-weight-heparin. Journal of Drug Targeting (in press).
  • 77
    • 0024427918 scopus 로고
    • New heparin complexes active by intestinal absorption: I. Multiple ion pairs with basic organic compounds
    • Dal Pozzo A., Acquasaliente M., Geron M.R., and Andriuoli G. New heparin complexes active by intestinal absorption: I. Multiple ion pairs with basic organic compounds. Thromb. Res. 56 1 (1989) 119-124
    • (1989) Thromb. Res. , vol.56 , Issue.1 , pp. 119-124
    • Dal Pozzo, A.1    Acquasaliente, M.2    Geron, M.R.3    Andriuoli, G.4
  • 79
    • 0031404885 scopus 로고    scopus 로고
    • Oral delivery of heparin in combination with sodium N-[8-(2-hydroxybenzoyl)amino]caprylate: pharmacological considerations
    • Rivera T.M., Leone-Bay A., Paton D.R., Leipold H.R., and Baughman R.A. Oral delivery of heparin in combination with sodium N-[8-(2-hydroxybenzoyl)amino]caprylate: pharmacological considerations. Pharm. Res. 14 12 (1997) 1830-1834
    • (1997) Pharm. Res. , vol.14 , Issue.12 , pp. 1830-1834
    • Rivera, T.M.1    Leone-Bay, A.2    Paton, D.R.3    Leipold, H.R.4    Baughman, R.A.5
  • 80
    • 0037433841 scopus 로고    scopus 로고
    • Small particles of a heparin/chitosan complex prepared from a pharmaceutically acceptable microemulsion
    • Andersson M., and Lofroth J.E. Small particles of a heparin/chitosan complex prepared from a pharmaceutically acceptable microemulsion. Int. J. Pharm. 257 1-2 (2003) 305-309
    • (2003) Int. J. Pharm. , vol.257 , Issue.1-2 , pp. 305-309
    • Andersson, M.1    Lofroth, J.E.2
  • 81
    • 1642579649 scopus 로고    scopus 로고
    • Study of the micellization behavior of different order amino block copolymers with heparin
    • Dufresne M.H., and Leroux J.C. Study of the micellization behavior of different order amino block copolymers with heparin. Pharm. Res. 21 1 (2004) 160-169
    • (2004) Pharm. Res. , vol.21 , Issue.1 , pp. 160-169
    • Dufresne, M.H.1    Leroux, J.C.2
  • 82
    • 0033430984 scopus 로고    scopus 로고
    • Microemulsions: an overview and pharmaceutical applications
    • Tenjarla S. Microemulsions: an overview and pharmaceutical applications. Crit. Rev. Ther. Drug Carrier Syst. 16 5 (1999) 461-521
    • (1999) Crit. Rev. Ther. Drug Carrier Syst. , vol.16 , Issue.5 , pp. 461-521
    • Tenjarla, S.1
  • 83
    • 0038387390 scopus 로고    scopus 로고
    • The dawning era of polymer therapeutics
    • Duncan R. The dawning era of polymer therapeutics. Nat. Rev. Drug. Discov. 2 5 (2003) 347-360
    • (2003) Nat. Rev. Drug. Discov. , vol.2 , Issue.5 , pp. 347-360
    • Duncan, R.1
  • 84
    • 0018842307 scopus 로고
    • Tailoring liposome structure
    • Gregoriadis G. Tailoring liposome structure. Nature 283 5750 (1980) 814-815
    • (1980) Nature , vol.283 , Issue.5750 , pp. 814-815
    • Gregoriadis, G.1
  • 85
    • 0022363671 scopus 로고
    • Oral administration of low molecular weight heparin fractions in rabbits
    • Doutremepuich C., Toulemonde F., and Lormeau J.C. Oral administration of low molecular weight heparin fractions in rabbits. Semin. Thromb. Hemost. 11 3 (1985) 323-325
    • (1985) Semin. Thromb. Hemost. , vol.11 , Issue.3 , pp. 323-325
    • Doutremepuich, C.1    Toulemonde, F.2    Lormeau, J.C.3
  • 86
    • 33745273133 scopus 로고    scopus 로고
    • G. Andriuoli, M. Bossi, I. Caramazza, G. Zoppetti, Heparin by alternative routes of administration, (1990).
  • 87
    • 0036273993 scopus 로고    scopus 로고
    • Delivery of LMW heparin via surface coated chitosan/peg-alginate microspheres prevents thrombosis
    • Chandy T., Rao G.H., Wilson R.F., and Das G.S. Delivery of LMW heparin via surface coated chitosan/peg-alginate microspheres prevents thrombosis. Drug Deliv. 9 2 (2002) 87-96
    • (2002) Drug Deliv. , vol.9 , Issue.2 , pp. 87-96
    • Chandy, T.1    Rao, G.H.2    Wilson, R.F.3    Das, G.S.4
  • 88
    • 0017149366 scopus 로고
    • Effects of acidity, cations and alcoholic fractionation on absorption of heparin from gastrointestinal tract
    • Sue T.K., Jaques L.B., and Yuen E. Effects of acidity, cations and alcoholic fractionation on absorption of heparin from gastrointestinal tract. Can. J. Physiol. Pharmacol. 54 4 (1976) 613-617
    • (1976) Can. J. Physiol. Pharmacol. , vol.54 , Issue.4 , pp. 613-617
    • Sue, T.K.1    Jaques, L.B.2    Yuen, E.3
  • 90
    • 0030993565 scopus 로고    scopus 로고
    • The oral absorption of micro- and nanoparticulates: neither exceptional nor unusual
    • Florence A.T. The oral absorption of micro- and nanoparticulates: neither exceptional nor unusual. Pharm. Res. 14 3 (1997) 259-266
    • (1997) Pharm. Res. , vol.14 , Issue.3 , pp. 259-266
    • Florence, A.T.1
  • 92
    • 0016195788 scopus 로고
    • Rectal administration of drugs
    • Senior N. Rectal administration of drugs. Adv. Pharm. Sci. 4 (1974) 363-435
    • (1974) Adv. Pharm. Sci. , vol.4 , pp. 363-435
    • Senior, N.1
  • 93
    • 0034467005 scopus 로고    scopus 로고
    • Intestinal absorption of low molecular weight heparin in animals and human subjects
    • Nissan A., Ziv E., Kidron M., Bar-On H., Friedman G., Hyam E., and Eldor A. Intestinal absorption of low molecular weight heparin in animals and human subjects. Haemostasis 30 5 (2000) 225-232
    • (2000) Haemostasis , vol.30 , Issue.5 , pp. 225-232
    • Nissan, A.1    Ziv, E.2    Kidron, M.3    Bar-On, H.4    Friedman, G.5    Hyam, E.6    Eldor, A.7
  • 94
    • 0020584531 scopus 로고
    • Bile salts facilitate the absorption of heparin from the intestine
    • Ziv E., Eldor A., Kleinman Y., Bar-On H., and Kidron M. Bile salts facilitate the absorption of heparin from the intestine. Biochem. Pharmacol. 32 5 (1983) 773-776
    • (1983) Biochem. Pharmacol. , vol.32 , Issue.5 , pp. 773-776
    • Ziv, E.1    Eldor, A.2    Kleinman, Y.3    Bar-On, H.4    Kidron, M.5
  • 95
    • 0019774395 scopus 로고
    • Rectal absorption of some glycosaminoglycan sulphates and heparin in rats
    • Stanzani L., Mascellani G., Corbelli G.P., and Bianchini P. Rectal absorption of some glycosaminoglycan sulphates and heparin in rats. J. Pharm. Pharmacol. 33 12 (1981) 783-786
    • (1981) J. Pharm. Pharmacol. , vol.33 , Issue.12 , pp. 783-786
    • Stanzani, L.1    Mascellani, G.2    Corbelli, G.P.3    Bianchini, P.4
  • 96
    • 0021262783 scopus 로고
    • Rectal absorption of lysozyme and heparin in rabbits in the presence of non-surfactant adjuvants
    • Miyake M., Nishihata T., Wada N., Takeshima E., and Kamada A. Rectal absorption of lysozyme and heparin in rabbits in the presence of non-surfactant adjuvants. Chem. Pharm. Bull. (Tokyo) 32 5 (1984) 2020-2025
    • (1984) Chem. Pharm. Bull. (Tokyo) , vol.32 , Issue.5 , pp. 2020-2025
    • Miyake, M.1    Nishihata, T.2    Wada, N.3    Takeshima, E.4    Kamada, A.5
  • 97
    • 0030853187 scopus 로고    scopus 로고
    • Optimizing therapy for inflammatory bowel disease
    • Robinson M. Optimizing therapy for inflammatory bowel disease. Am. J. Gastroenterol. 92 12 Suppl (1997) 12S-17S
    • (1997) Am. J. Gastroenterol. , vol.92 , Issue.12 SUPPL
    • Robinson, M.1
  • 98
    • 0032196418 scopus 로고    scopus 로고
    • Prevention of deep vein thrombosis (DVT) with the low molecular weight heparin (LMWH) and epidural/spinal anesthesia. The efficacy viewpoint
    • Cyrkowicz A., Fiala J., Kacalski J., Jackowski P., Bielaszka K., and Smida A. Prevention of deep vein thrombosis (DVT) with the low molecular weight heparin (LMWH) and epidural/spinal anesthesia. The efficacy viewpoint. Ginekol. Pol. 69 11 (1998) 795-799
    • (1998) Ginekol. Pol. , vol.69 , Issue.11 , pp. 795-799
    • Cyrkowicz, A.1    Fiala, J.2    Kacalski, J.3    Jackowski, P.4    Bielaszka, K.5    Smida, A.6
  • 99
    • 0027181919 scopus 로고
    • Massive septic pelvic thrombophlebitis
    • Magee K.P., Blanco J.D., and Graham J.M. Massive septic pelvic thrombophlebitis. Obstet. Gynecol. 82 4 Pt 2 Suppl (1993) 662-664
    • (1993) Obstet. Gynecol. , vol.82 , Issue.4 PART 2 SUPPL , pp. 662-664
    • Magee, K.P.1    Blanco, J.D.2    Graham, J.M.3
  • 100
    • 0028929407 scopus 로고
    • Postpartum ovarian vein thrombosis after vaginal delivery: a report of 11 cases
    • Witlin A.G., and Sibai B.M. Postpartum ovarian vein thrombosis after vaginal delivery: a report of 11 cases. Obstet. Gynecol. 85 5 Pt 1 (1995) 775-780
    • (1995) Obstet. Gynecol. , vol.85 , Issue.5 PART 1 , pp. 775-780
    • Witlin, A.G.1    Sibai, B.M.2
  • 101
    • 0038201927 scopus 로고    scopus 로고
    • Nasal drug delivery
    • Suman J.D. Nasal drug delivery. Expert Opin. Biol. Ther. 3 3 (2003) 519-523
    • (2003) Expert Opin. Biol. Ther. , vol.3 , Issue.3 , pp. 519-523
    • Suman, J.D.1
  • 102
    • 1542724890 scopus 로고    scopus 로고
    • Chain length-dependent effects of alkylmaltosides on nasal absorption of enoxaparin
    • Mustafa F., Yang T., Khan M.A., and Ahsan F. Chain length-dependent effects of alkylmaltosides on nasal absorption of enoxaparin. J. Pharm. Sci. 93 3 (2004) 675-683
    • (2004) J. Pharm. Sci. , vol.93 , Issue.3 , pp. 675-683
    • Mustafa, F.1    Yang, T.2    Khan, M.A.3    Ahsan, F.4
  • 103
    • 0036284795 scopus 로고    scopus 로고
    • Synthetic long-chain alkyl maltosides and alkyl sucrose esters as enhancers of nasal insulin absorption
    • Pillion D.J., Ahsan F., Arnold J.J., Balusubramanian B.M., Piraner O., and Meezan E. Synthetic long-chain alkyl maltosides and alkyl sucrose esters as enhancers of nasal insulin absorption. J. Pharm. Sci. 91 6 (2002) 1456-1462
    • (2002) J. Pharm. Sci. , vol.91 , Issue.6 , pp. 1456-1462
    • Pillion, D.J.1    Ahsan, F.2    Arnold, J.J.3    Balusubramanian, B.M.4    Piraner, O.5    Meezan, E.6
  • 106
    • 0030630763 scopus 로고    scopus 로고
    • Changes in hemostasis and vagal tonus in healthy individuals and patients with facial neuropathy by micro-dose heparin stimulation of nasal receptors
    • Uryvaev I.V., Iudel'son I.B., and Sergeev V.V. Changes in hemostasis and vagal tonus in healthy individuals and patients with facial neuropathy by micro-dose heparin stimulation of nasal receptors. Vestn. Ross. Akad. Med. Nauk. 8 (1997) 22-23
    • (1997) Vestn. Ross. Akad. Med. Nauk. , vol.8 , pp. 22-23
    • Uryvaev, I.V.1    Iudel'son, I.B.2    Sergeev, V.V.3
  • 107
    • 0035998957 scopus 로고    scopus 로고
    • Nasal administration of low molecular weight heparin
    • Arnold J., Ahsan F., Meezan E., and Pillion D.J. Nasal administration of low molecular weight heparin. J Pharm Sci 91 7 (2002) 1707-1714
    • (2002) J Pharm Sci , vol.91 , Issue.7 , pp. 1707-1714
    • Arnold, J.1    Ahsan, F.2    Meezan, E.3    Pillion, D.J.4
  • 108
    • 0032484588 scopus 로고    scopus 로고
    • Nasal delivery systems and their effect on deposition and absorption
    • Vidgren M.T., and Kublik H. Nasal delivery systems and their effect on deposition and absorption. Adv. Drug Deliv. Rev. 29 1-2 (1998) 157-177
    • (1998) Adv. Drug Deliv. Rev. , vol.29 , Issue.1-2 , pp. 157-177
    • Vidgren, M.T.1    Kublik, H.2
  • 109
  • 110
    • 0017120034 scopus 로고
    • Intrapulmonary heparin. A new procedure for anticoagulant therapy
    • Jaques L.B., Mahadoo J., and Kavanagh L.W. Intrapulmonary heparin. A new procedure for anticoagulant therapy. Lancet 2 7996 (1976) 1157-1161
    • (1976) Lancet , vol.2 , Issue.7996 , pp. 1157-1161
    • Jaques, L.B.1    Mahadoo, J.2    Kavanagh, L.W.3
  • 111
    • 0037310266 scopus 로고    scopus 로고
    • Effect of covalent serpin-heparinoid complexes on plasma thrombin generation on fetal distal lung epithelium
    • Berry L.R., Klement P., Andrew M., and Chan A.K. Effect of covalent serpin-heparinoid complexes on plasma thrombin generation on fetal distal lung epithelium. Am. J. Respir. Cell. Mol. Biol. 28 2 (2003) 150-158
    • (2003) Am. J. Respir. Cell. Mol. Biol. , vol.28 , Issue.2 , pp. 150-158
    • Berry, L.R.1    Klement, P.2    Andrew, M.3    Chan, A.K.4
  • 112
    • 20444403247 scopus 로고    scopus 로고
    • Pulmonary delivery of low molecular weight heparins
    • Yang T., Mustafa F., Bai S., and Ahsan F. Pulmonary delivery of low molecular weight heparins. Pharm. Res. 21 11 (2004) 2009-2016
    • (2004) Pharm. Res. , vol.21 , Issue.11 , pp. 2009-2016
    • Yang, T.1    Mustafa, F.2    Bai, S.3    Ahsan, F.4
  • 113
    • 0029564079 scopus 로고
    • The effect of inhaled heparin and related glycosaminoglycans on allergen-induced eosinophil infiltration in guinea-pigs
    • Seeds E.A., Horne A.P., Tyrrell D.J., and Page C.P. The effect of inhaled heparin and related glycosaminoglycans on allergen-induced eosinophil infiltration in guinea-pigs. Pulm. Pharmacol. 8 2-3 (1995) 97-105
    • (1995) Pulm. Pharmacol. , vol.8 , Issue.2-3 , pp. 97-105
    • Seeds, E.A.1    Horne, A.P.2    Tyrrell, D.J.3    Page, C.P.4
  • 116
    • 0026596865 scopus 로고
    • Effects of inhaled heparin on immunologic and nonimmunologic bronchoconstrictor responses in sheep
    • Ahmed T., Abraham W.M., and D'Brot J. Effects of inhaled heparin on immunologic and nonimmunologic bronchoconstrictor responses in sheep. Am. Rev. Respir. Dis. 145 3 (1992) 566-570
    • (1992) Am. Rev. Respir. Dis. , vol.145 , Issue.3 , pp. 566-570
    • Ahmed, T.1    Abraham, W.M.2    D'Brot, J.3
  • 117
    • 0031910009 scopus 로고    scopus 로고
    • Breathing life into protein drugs
    • Patton J. Breathing life into protein drugs. Nat. Biotechnol. 16 2 (1998) 141-143
    • (1998) Nat. Biotechnol. , vol.16 , Issue.2 , pp. 141-143
    • Patton, J.1
  • 118
    • 0034071286 scopus 로고    scopus 로고
    • Effects of inhaled low molecular weight heparin on airway allergic inflammation in aerosol-ovalbumin-sensitized guinea pigs
    • Wang Q.L., Shang X.Y., Zhang S.L., Ji J.B., Cheng Y.N., Meng Y.J., and Zhu Y.J. Effects of inhaled low molecular weight heparin on airway allergic inflammation in aerosol-ovalbumin-sensitized guinea pigs. Jpn. J. Pharmacol. 82 4 (2000) 326-330
    • (2000) Jpn. J. Pharmacol. , vol.82 , Issue.4 , pp. 326-330
    • Wang, Q.L.1    Shang, X.Y.2    Zhang, S.L.3    Ji, J.B.4    Cheng, Y.N.5    Meng, Y.J.6    Zhu, Y.J.7
  • 119
    • 0027434514 scopus 로고
    • Heparin inhibits the immediate response to antigen in the skin and lungs of allergic subjects
    • Bowler S.D., Smith S.M., and Lavercombe P.S. Heparin inhibits the immediate response to antigen in the skin and lungs of allergic subjects. Am. Rev. Respir. Dis. 147 1 (1993) 160-163
    • (1993) Am. Rev. Respir. Dis. , vol.147 , Issue.1 , pp. 160-163
    • Bowler, S.D.1    Smith, S.M.2    Lavercombe, P.S.3
  • 120
    • 0034141855 scopus 로고    scopus 로고
    • Inhaled heparin is effective in exacerbations of asthma
    • Bendstrup K.E., and Jensen J.I. Inhaled heparin is effective in exacerbations of asthma. Respir. Med. 94 2 (2000) 174-175
    • (2000) Respir. Med. , vol.94 , Issue.2 , pp. 174-175
    • Bendstrup, K.E.1    Jensen, J.I.2
  • 121
    • 0033657642 scopus 로고    scopus 로고
    • Percutaneous absorption of heparin: a critical review of experimental results
    • Sznitowska M., and Janicki S. Percutaneous absorption of heparin: a critical review of experimental results. Pol .Merkuriusz. Lek. 7 43 (2000) 58-63
    • (2000) Pol .Merkuriusz. Lek. , vol.7 , Issue.43 , pp. 58-63
    • Sznitowska, M.1    Janicki, S.2
  • 122
    • 0017169765 scopus 로고
    • Penetration, permeation and resorption of heparin. In vivo studies on human skin
    • Zesch A., and Schaefer H. Penetration, permeation and resorption of heparin. In vivo studies on human skin. Arzneimittelforschung 26 7 (1976) 1365-1368
    • (1976) Arzneimittelforschung , vol.26 , Issue.7 , pp. 1365-1368
    • Zesch, A.1    Schaefer, H.2
  • 123
    • 0030747741 scopus 로고    scopus 로고
    • Topical application of low molecular weight heparin in a rabbit traumatic anastomosis model
    • Fu K., Izquierdo R., Vandevender D., Warpeha R.L., Wolf H., and Fareed J. Topical application of low molecular weight heparin in a rabbit traumatic anastomosis model. Thromb. Res. 86 5 (1997) 355-361
    • (1997) Thromb. Res. , vol.86 , Issue.5 , pp. 355-361
    • Fu, K.1    Izquierdo, R.2    Vandevender, D.3    Warpeha, R.L.4    Wolf, H.5    Fareed, J.6
  • 124
    • 0141743473 scopus 로고    scopus 로고
    • Liposomal heparin-spraygel in comparison with subcutaneous low molecular weight heparin in patients with superficial venous thrombosis. A randomized, controlled, open multicentre study
    • Katzenschlager R., Ugurluoglu A., and Hirsch M. Liposomal heparin-spraygel in comparison with subcutaneous low molecular weight heparin in patients with superficial venous thrombosis. A randomized, controlled, open multicentre study. J. Kardiol. 10 9 (2003) 375-378
    • (2003) J. Kardiol. , vol.10 , Issue.9 , pp. 375-378
    • Katzenschlager, R.1    Ugurluoglu, A.2    Hirsch, M.3
  • 125
    • 0035834195 scopus 로고    scopus 로고
    • Heparin penetration into and permeation through human skin from aqueous and liposomal formulations in vitro
    • Betz G., Nowbakht P., Imboden R., and Imanidis G. Heparin penetration into and permeation through human skin from aqueous and liposomal formulations in vitro. Int. J. Pharm 228 1-2 (2001) 147-159
    • (2001) Int. J. Pharm , vol.228 , Issue.1-2 , pp. 147-159
    • Betz, G.1    Nowbakht, P.2    Imboden, R.3    Imanidis, G.4
  • 126
    • 0034813451 scopus 로고    scopus 로고
    • Transdermal delivery of heparin and low-molecular weight heparin using low-frequency ultrasound
    • Mitragotri S., and Kost J. Transdermal delivery of heparin and low-molecular weight heparin using low-frequency ultrasound. Pharm. Res. 18 8 (2001) 1151-1156
    • (2001) Pharm. Res. , vol.18 , Issue.8 , pp. 1151-1156
    • Mitragotri, S.1    Kost, J.2
  • 127
    • 0033755812 scopus 로고    scopus 로고
    • Combined effect of low-frequency ultrasound and iontophoresis: applications for transdermal heparin delivery
    • Le L., Kost J., and Mitragotri S. Combined effect of low-frequency ultrasound and iontophoresis: applications for transdermal heparin delivery. Pharm. Res. 17 9 (2000) 1151-1154
    • (2000) Pharm. Res. , vol.17 , Issue.9 , pp. 1151-1154
    • Le, L.1    Kost, J.2    Mitragotri, S.3
  • 129
    • 0030902518 scopus 로고    scopus 로고
    • Macromolecules as novel transdermal transport enhancers for skin electroporation
    • Vanbever R., Prausnitz M.R., and Preat V. Macromolecules as novel transdermal transport enhancers for skin electroporation. Pharm. Res. 14 5 (1997) 638-644
    • (1997) Pharm. Res. , vol.14 , Issue.5 , pp. 638-644
    • Vanbever, R.1    Prausnitz, M.R.2    Preat, V.3
  • 132
    • 0033692993 scopus 로고    scopus 로고
    • Delivery of low molecular weight heparin for prophylaxis against deep vein thrombosis using a novel, needle-less injection device (J-Tip)
    • Hollingsworth S.J., Hoque K., Linnard D., Corry D.G., and Barker S.G. Delivery of low molecular weight heparin for prophylaxis against deep vein thrombosis using a novel, needle-less injection device (J-Tip). Ann. R. Coll. Surg. Engl. 82 6 (2000) 428-431
    • (2000) Ann. R. Coll. Surg. Engl. , vol.82 , Issue.6 , pp. 428-431
    • Hollingsworth, S.J.1    Hoque, K.2    Linnard, D.3    Corry, D.G.4    Barker, S.G.5
  • 133
    • 0344270926 scopus 로고    scopus 로고
    • Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: fabrication methods and transport studies
    • McAllister D.V., Wang P.M., Davis S.P., Park J.H., Canatella P.J., Allen M.G., and Prausnitz M.R. Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: fabrication methods and transport studies. Proc. Natl. Acad. Sci. U. S. A. 100 24 (2003) 13755-13760
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , Issue.24 , pp. 13755-13760
    • McAllister, D.V.1    Wang, P.M.2    Davis, S.P.3    Park, J.H.4    Canatella, P.J.5    Allen, M.G.6    Prausnitz, M.R.7
  • 134
    • 14944376721 scopus 로고    scopus 로고
    • Healing sound: the use of ultrasound in drug delivery and other therapeutic applications
    • Mitragotri S. Healing sound: the use of ultrasound in drug delivery and other therapeutic applications. Nat. Rev. Drug Discov. 4 3 (2005) 255-260
    • (2005) Nat. Rev. Drug Discov. , vol.4 , Issue.3 , pp. 255-260
    • Mitragotri, S.1
  • 136
    • 1842430006 scopus 로고    scopus 로고
    • Bacterial invasion: the paradigms of enteroinvasive pathogens
    • Cossart P., and Sansonetti P.J. Bacterial invasion: the paradigms of enteroinvasive pathogens. Science 304 5668 (2004) 242-248
    • (2004) Science , vol.304 , Issue.5668 , pp. 242-248
    • Cossart, P.1    Sansonetti, P.J.2
  • 138
    • 4444330530 scopus 로고    scopus 로고
    • Nanoscale technology of mucoadhesive interactions
    • Peppas N.A., and Huang Y. Nanoscale technology of mucoadhesive interactions. Adv. Drug Deliv. Rev. 56 11 (2004) 1675-1687
    • (2004) Adv. Drug Deliv. Rev. , vol.56 , Issue.11 , pp. 1675-1687
    • Peppas, N.A.1    Huang, Y.2
  • 141
    • 4444360199 scopus 로고    scopus 로고
    • Delineating mechanisms of dissociation for isomeric heparin disaccharides using isotope labeling and ion trap tandem mass spectrometry
    • Saad O.M., and Leary J.A. Delineating mechanisms of dissociation for isomeric heparin disaccharides using isotope labeling and ion trap tandem mass spectrometry. J. Am. Soc. Mass. Spectrom. 15 9 (2004) 1274-1286
    • (2004) J. Am. Soc. Mass. Spectrom. , vol.15 , Issue.9 , pp. 1274-1286
    • Saad, O.M.1    Leary, J.A.2
  • 142
    • 0037030653 scopus 로고    scopus 로고
    • Molecular properties that influence the oral bioavailability of drug candidates
    • Veber D.F., Johnson S.R., Cheng H.Y., Smith B.R., Ward K.W., and Kopple K.D. Molecular properties that influence the oral bioavailability of drug candidates. J. Med. Chem. 45 12 (2002) 2615-2623
    • (2002) J. Med. Chem. , vol.45 , Issue.12 , pp. 2615-2623
    • Veber, D.F.1    Johnson, S.R.2    Cheng, H.Y.3    Smith, B.R.4    Ward, K.W.5    Kopple, K.D.6
  • 143
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski C.A., Lombardo F., Dominy B.W., and Feeney P.J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug. Deliv. Rev. 46 1-3 (2001) 3-26
    • (2001) Adv. Drug. Deliv. Rev. , vol.46 , Issue.1-3 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 144
  • 145
    • 0017143535 scopus 로고
    • Absorption of heparin and cyanocobalamin from the rat lung
    • Schanker L.S., and Burton J.A. Absorption of heparin and cyanocobalamin from the rat lung. Proc. Soc. Exp. Biol. Med. 152 3 (1976) 377-380
    • (1976) Proc. Soc. Exp. Biol. Med. , vol.152 , Issue.3 , pp. 377-380
    • Schanker, L.S.1    Burton, J.A.2
  • 146
    • 0027159470 scopus 로고
    • Preventing bronchoconstriction in exercise-induced asthma with inhaled heparin
    • Ahmed T., Garrigo J., and Danta I. Preventing bronchoconstriction in exercise-induced asthma with inhaled heparin. N. Engl. J. Med. 329 2 (1993) 90-95
    • (1993) N. Engl. J. Med. , vol.329 , Issue.2 , pp. 90-95
    • Ahmed, T.1    Garrigo, J.2    Danta, I.3
  • 147
    • 0036212002 scopus 로고    scopus 로고
    • Effect of inhaled heparin on lung function and coagulation in healthy volunteers
    • Bendstrup K.E., Gram J., and Jensen J.I. Effect of inhaled heparin on lung function and coagulation in healthy volunteers. Eur. Respir. J. 19 4 (2002) 606-610
    • (2002) Eur. Respir. J. , vol.19 , Issue.4 , pp. 606-610
    • Bendstrup, K.E.1    Gram, J.2    Jensen, J.I.3


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