Enhancement of heparin and heparin disaccharide absorption by thePhytolacca americana saponins

Archives of Pharmacal Research

Volumn 26, Issue 12, 2003, Pages 1102-1108

  Cho, So Yean ^a   Sim, Joon Soo ^a   Kang, Sam Sik ^a   Jeong, Choon Sik ^b   Linhardt, Robert J ^c   Kim, Yeong Shik ^a  

^a Seoul National University   (South Korea)

^b Duksung Women's University   (South Korea)

^c RENSSELAER POLYTECHNIC INSTITUTE   (United States)

Author keywords

Absorption enhancer; Caco 2 cells; Heparin; Heparin disaccharide; Phytolaccosides

Indexed keywords

DISACCHARIDE; DRUG DERIVATIVE; HEPARIN; HEPARIN DISACCHARIDE; PHARMACEUTICAL VEHICLES AND ADDITIVES; SAPONIN;

ANIMAL; ARTICLE; CELL STRAIN CACO 2; CHEMISTRY; DRUG EFFECT; DRUG POTENTIATION; HUMAN; INSTITUTE FOR CANCER RESEARCH MOUSE; INTESTINE ABSORPTION; ISOLATION AND PURIFICATION; MALE; MOUSE; PHYSIOLOGY; PLANT ROOT; POKEWEED; STOMACH MUCOSA; SWINE;

ADJUVANTS, PHARMACEUTIC; ANIMALS; CACO-2 CELLS; DISACCHARIDES; DRUG SYNERGISM; GASTRIC MUCOSA; HEPARIN; HUMANS; INTESTINAL ABSORPTION; MALE; MICE; MICE, INBRED ICR; PHYTOLACCA AMERICANA; PLANT ROOTS; SAPONINS; SWINE;

EID: 4143053457     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/BF02994765     Document Type: Article

References (30)

1. Anderson, J. M. and van Itallie, C. M., Tight junctions and the molecular basis for regulation of paracellular permeability.Am. J. Physiol., 269, 467–475 (1995).
2. Baughman, R. A., Kapoor, S. C., Agarwal, R. K., Kisicki, J., Catella-Lawson, F., and FitzGerald, G. A., Oral delivery of anticoagulant doses of heparin. A randomized, double- blind, controlled study in humans.Circulation, 98, 1610–1615 (1998).
3. Brayden, D., Creed, E., O’Connell, A., Leipold, H., Agarwal, R., and Leone-Bay, A., Heparin absorption across the intestine: effects of sodiu.N-[8-(2-hydroxybenzoyl)amino]caprylate in ratin situ intestinal instillations and in Caco-2 monolayers.Pharm. Res., 14, 1772–1779 (1997). DOI: 10.1023/A:1012192115828
4. Caramazza, I., D’Atri, G., Bossi, M. L., De Ponti, F., D’Angelo, L., and Crema, A., Intraduodenal absorption of the new UF-heparin salt ITF 1057 in the conscious dog.Thromb. Res., 62, 785–789 (1991). DOI: 10.1016/0049-3848(91)90383-8
5. Chao, A. C., Nguyen, J. V., Broughall, M., Recchia, J., Kensil, C. R., Daddona, P. E., and Fix, J. A., Enhancement of intestinal model compound transport by DS-1, a modifie.Quillaja saponin.J. Pharm. Sci., 87, 1395–1399 (1998). DOI: 10.1021/js9800735
6. Choksakulnimitr, S., Masuda, S., Tokuda, H., Takakura, Y., and Hashida, M.,In vitro cytotoxicity of macromolecules in different cell culture systems.J. Control. Release, 34, 233–241 (1995). DOI: 10.1016/0168-3659(95)00007-U
7. Dal Pozzo, A., Acquasaliente, M., Geron, M. R., and Andriuoli, G., New heparin complexes active by intestinal absorption: Imultiple ion pairs with basic organic compounds.Thromb. Res., 56, 119–124 (1989). DOI: 10.1016/0049-3848(89)90014-5
8. Engel, R. H. and Fahrenbach, M. J., Intestinal absorption of heparin in the rat and gerbil.Proc. Soc. Exp. Biol. Med., 129, 772–777 (1968).
9. Kang, S. S. and Woo, W. S., Two new saponins fro.Phyto lacca americana.Planta Med., 53, 338–340 (1987). DOI: 10.1055/s-2006-962732
10. Kang, S. S. and Woo, W. S., Phytolaccoside I, a new saponin fromPhytolacca americana. Fitoterapia, LXII, 532–533 (1991).
11. Kim, B. I., Kim, W. S., Kim, Y. S., Linhardt, R. J., and Kim, D. H., Purification and characterization of a novel heparinase fromBacteroides stercoris HJ-15.J. Biochem. (Tokyo), 128, 323–328 (2000).
12. Kim, T. D., Sakon, M., Kawasaki, T., Kambayashi, J., Ohshiro, T., and Mori, T., Studies on liposome-encapsulated heparin.Thromb. Res., 43, 603–612 (1986). DOI: 10.1016/0049-3848(86)90097-6
13. Koh, T. Y. and Bharucha, K. R., Intestinal absorption of stable heparinic acid complexes.J. Lab. Clin. Med., 80, 47–55 (1972).
14. Kusakabe, M., Sakakura, T., Nishizuka, Y., Sano, M., and Matsukage, A., Polyester wax embedding and sectioning technique for immunohistochemistry.Stain Technol., 59, 127–132 (1984).
15. Leone-Bay, A., Paton, D. R., Freeman, J., Lercara, C., O’Toole, D., Gschneidner, D., Wang, E., Harris, E., Rosado, C., Rivera, T., DeVincent, A., Tai, M., Mercogliano, F., Agarwal, R., Leipold, H., and Baughman, R. A., Synthesis and evaluation of compounds that facilitate the gastrointestinal absorption of heparin.J. Med. Chem., 41, 1163–1171 (1998). DOI: 10.1021/jm970811m
16. Liu, D. Z., LeCluyse, E. L., and Thakker, D. R., Dodecylphosphocholine-mediated enhancement of paracellular permeability and cytotoxicity in Caco-2 cell monolayers.J. Pharm. Sci., 88, 1161–1168 (1999). DOI: 10.1021/js990094e
17. Merchant, Z. M., Kim, Y S., Rice, K. G., and Linhardt, R. J., Structure of heparin-derived tetrasaccharides.Biochem. J., 229, 369–377 (1985).
18. Narai, A., Arai, S., and Shimizu, M., Rapid decrease in transepithelial electrical resistance of human intestinal Caco-2 cell monolayers by cytotoxic membrane perturbents.Toxicol, in Vitro, 11, 347–354 (1997). DOI: 10.1016/S0887-2333(97)00026-X
19. Onning, G., Wang, Q., Westrom, B. R., Asp, N. G., and Karlsson, B. W., Influence of oat saponins on intestinal permeabilit.in vitro andin vivo in the rat.Br. J. Nutr, 76, 141–151 (1996). DOI: 10.1079/BJN19960016
20. Rivera, T. M., Leone-Bay, A., Paton, D. R., Leipold, H. R., and Baughman, R. A., Oral delivery of heparin in combination with sodium A/-[8-(2-hydroxybenzoyl)amino]caprylate: pharmacological considerations.Pharm. Res., 14, 1830–1834 (1997). DOI: 10.1023/A:1012160703533
21. Sasaki, H., Yamamura, K., Mukai, T., Nishida, K., Nakamura, J., Nakashima, M., and Ichikawa, M., Modification of ocular permeability of peptide drugs by absorption promoters.Biol. Pharm. Bull., 23, 1524–1527 (2000).
22. Sue, T. K., Jaques, L. B., and Yuen, E., Effects of acidity, cations and alcoholic fractionation on absorption of heparin from gastrointestinal tract.Can. J. Physiol. Pharmacol., 54, 613–617 (1976).
23. Sung, M. K., Kendall, C. W., and Rao, A. V., Effect of soybean saponins an.Gypsophila saponin on morphology of colon carcinoma cells in culture.Food Chem. Toxicol., 33, 357–366 (1995). DOI: 10.1016/0278-6915(95)00007-O
24. Thanou, M., Nihot, M. T., Jansen, M., Verhoef, J. C., and Junginger, H. E., Mono-N-carboxymethyl chitosan (MCC), a polyampholytic chitosan derivative, enhances the intestinal absorption of low molecular weight heparin across intestinal epitheliain vitro andin vivo. J. Pharm. Sci., 90, 38–46 (2001). DOI: 10.1002/1520-6017(200101)90:1<38::AID-JPS5>3.0.CO;2-3
25. Tidball, C. S. and Lipman, R. I., Enhancement of jejunal absorption of heparinoid by sodium ethylendiaminetetraacetate in the dog.Proc. Soc. Exp. Biol. Med., 111, 713–715 (1962).
26. Ueno, M., Nakasaki, T., Horikoshi, I., and Sakuragawa, N., Oral administration of liposomally-entrapped heparin to beagle dogs.Chem. Pharm. Bull., 30, 2245–2247 (1982).
27. Ward, P. D., Tippin, T. K., and Thakker, D. R., Enhancing paracellular permeability by modulating epithelial tight junctions.Pharm. Sci. Technol. Today, 3, 346–358 (2000). DOI: 10.1016/S1461-5347(00)00302-3
28. Winsor E., and Cronheim, G. E., Gastro-intestinal absorption of heparin and heparinoids.Nature, 190, 263–264 (1961). DOI: 10.1038/190263a0
29. Woo, W. S., Kang, S. S., Wagner, H., Seligmann, O., and Chari, V. M., Triterpenoid saponins from the roots o.Phytolacca americana.Planta Med., 34, 87–92 (1978). DOI: 10.1055/s-0028-1097419
30. Wu, S. J., Chun, M. W., Shin, K. H., Toida, T., Park, Y., Linhardt, R. J., and Kim, Y. S., Chemical sulfonation and anticoagulant activity of acharan sulfate.Thromb. Res., 92, 273–281 (1998). DOI: 10.1016/S0049-3848(98)00146-7