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Volumn 56, Issue , 2005, Pages 63-77

New anticoagulant therapy

Author keywords

Factor Va and VIIIa inhibitors; Factor VIIa tissue factor inhibitors; Factor Xa inhibitors; Thrombin inhibitors

Indexed keywords

2 [4 [(1 ACETIMIDOYL 3 PYRROLIDINYL)OXY]PHENYL] 3 (7 AMIDINO 2 NAPHTHYL)PROPIONIC ACID; ACETYLSALICYLIC ACID; ALTEPLASE; ANTICOAGULANT AGENT; ANTICOAGULANT PROTEIN; ANTIVITAMIN K; ARGATROBAN; BLOOD CLOTTING FACTOR 7A INHIBITOR; DABIGATRAN ETEXILATE; DALTEPARIN; DROTRECOGIN; ENOXAPARIN; FONDAPARINUX; HEPARIN; HIRUDIN; HIRULOG; IDRAPARINUX; LOW MOLECULAR WEIGHT HEPARIN; LY 517717; MELAGATRAN; NEMATODE ANTICOAGULANT PEPTIDE; PLACEBO; RAZAXABAN; RECOMBINANT TISSUE FACTOR PATHWAY INHIBITOR; RIVAROXABAN; THROMBOMODULIN; UNCLASSIFIED DRUG; WARFARIN; XIMELAGATRAN;

EID: 14544275123     PISSN: 00664219     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.med.56.082103.104708     Document Type: Review
Times cited : (32)

References (47)
  • 1
    • 0035159740 scopus 로고    scopus 로고
    • Assessment of the safety of recombinant tissue factor pathway inhibitor in patients with severe sepsis: A multicenter, randomized, placebo-controlled, single-blind, dose escalation study
    • Abraham E, Reinhart K, Svoboda P, et al. 2001. Assessment of the safety of recombinant tissue factor pathway inhibitor in patients with severe sepsis: a multicenter, randomized, placebo-controlled, single-blind, dose escalation study. Crit. Care Med. 29: 2081-89
    • (2001) Crit. Care Med. , vol.29 , pp. 2081-2089
    • Abraham, E.1    Reinhart, K.2    Svoboda, P.3
  • 2
    • 0038690407 scopus 로고    scopus 로고
    • Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: A randomized controlled trial
    • Abraham E, Reinhart K, Opal S, for the OPTIMIST Trial Study Group. 2003. Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial. JAMA 290:238-47
    • (2003) JAMA , vol.290 , pp. 238-247
    • Abraham, E.1    Reinhart, K.2    Opal, S.3
  • 3
    • 0000455702 scopus 로고    scopus 로고
    • Anticoagulant repertoire of the hookworm Ancylostoma caninum
    • Stassens P, Bergum PW, Gansemans Y, et al. 1996. Anticoagulant repertoire of the hookworm Ancylostoma caninum. Proc. Natl. Acad. Sci. USA 93:2149-54
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 2149-2154
    • Stassens, P.1    Bergum, P.W.2    Gansemans, Y.3
  • 4
    • 0035800075 scopus 로고    scopus 로고
    • Dose-response study of recombinant factor VIIa/tissue factor inhibitor recombinant nematode anticoagulant protein c2 in prevention of postoperative venous thromboembolism in patients undergoing total knee replacement
    • Lee A, Agnelli G, Buller H, et al. 2001. Dose-response study of recombinant factor VIIa/tissue factor inhibitor recombinant nematode anticoagulant protein c2 in prevention of postoperative venous thromboembolism in patients undergoing total knee replacement. Circulation 104:74-78
    • (2001) Circulation , vol.104 , pp. 74-78
    • Lee, A.1    Agnelli, G.2    Buller, H.3
  • 5
    • 0029912586 scopus 로고    scopus 로고
    • Role of tissue factor and factor VIIa in the coagulant and inflammatory response to LD100 Escherichia coli in the baboon
    • Taylor FB Jr. 1996. Role of tissue factor and factor VIIa in the coagulant and inflammatory response to LD100 Escherichia coli in the baboon. Haemostasis 26:83-91
    • (1996) Haemostasis , vol.26 , pp. 83-91
    • Taylor Jr., F.B.1
  • 6
    • 0028839499 scopus 로고
    • Influence of blockade at specific levels of the coagulant cascade on restenosis in a rabbit atherosclerotic femoral artery injury model
    • Jang Y, Guzman LA, Lincoff AM, et al. 1995. Influence of blockade at specific levels of the coagulant cascade on restenosis in a rabbit atherosclerotic femoral artery injury model. Circulation 92:3041-50
    • (1995) Circulation , vol.92 , pp. 3041-3050
    • Jang, Y.1    Guzman, L.A.2    Lincoff, A.M.3
  • 7
    • 0000684302 scopus 로고    scopus 로고
    • First clinical investigation of a tissue-factor inhibitor administered during percutaneous coronary revascularization: A randomized, double-blinded, dose-escalation trial - Assessing safety and efficacy of FFR-FVIIa in percutaneous transluminal coronary angioplasty (ASIS) trial
    • Abstr.
    • Lincoff AM. 2000. First clinical investigation of a tissue-factor inhibitor administered during percutaneous coronary revascularization: a randomized, double-blinded, dose-escalation trial-assessing safety and efficacy of FFR-FVIIa in percutaneous transluminal coronary angioplasty (ASIS) trial. J. Am. Coll. Cardiol. 36:312 (Abstr.)
    • (2000) J. Am. Coll. Cardiol. , vol.36 , pp. 312
    • Lincoff, A.M.1
  • 8
    • 0029588344 scopus 로고
    • Pharmacokinetics and tolerance of the natural pentasaccharide (SR90107/ORG31540) with high affinity to antithrombin III in man
    • Boneu B, Necciari J, Cariou R, et al. 1995. Pharmacokinetics and tolerance of the natural pentasaccharide (SR90107/ORG31540) with high affinity to antithrombin III in man. Thromb. Haemost. 74:1468-73
    • (1995) Thromb. Haemost. , vol.74 , pp. 1468-1473
    • Boneu, B.1    Necciari, J.2    Cariou, R.3
  • 9
    • 0037069334 scopus 로고    scopus 로고
    • Ability of recombinant factor VIIa to reverse the anticoagulant effect of the pentasaccharide fondaparinux in healthy volunteers
    • Bijsterveld NR, Moons AH, Boekholdt SM, et al. 2002. Ability of recombinant factor VIIa to reverse the anticoagulant effect of the pentasaccharide fondaparinux in healthy volunteers. Circulation 106:2550-54
    • (2002) Circulation , vol.106 , pp. 2550-2554
    • Bijsterveld, N.R.1    Moons, A.H.2    Boekholdt, S.M.3
  • 10
    • 0346364794 scopus 로고    scopus 로고
    • New pentasaccharides for the prophylaxis of venous thromboembolism: Clinical studies
    • Turpie AG, Eriksson BI, Bauer KA, Lassen MR. 2003. New pentasaccharides for the prophylaxis of venous thromboembolism: clinical studies. Chest 124:371S-78S
    • (2003) Chest , vol.124
    • Turpie, A.G.1    Eriksson, B.I.2    Bauer, K.A.3    Lassen, M.R.4
  • 11
    • 0038010814 scopus 로고    scopus 로고
    • Duration of prophylaxis against venous thromboembolism with fondaparinux after hip fracture surgery: A multicenter, randomized, placebo-controlled, double-blind study
    • Eriksson BI, Lassen MR, PENTasaccharide in Hip-FRAture Surgery Plus Investigators. 2003. Duration of prophylaxis against venous thromboembolism with fondaparinux after hip fracture surgery: a multicenter, randomized, placebo-controlled, double-blind study. Arch. Intern. Med. 163:1337-42
    • (2003) Arch. Intern. Med. , vol.163 , pp. 1337-1342
    • Eriksson, B.I.1    Lassen, M.R.2
  • 12
    • 0037163477 scopus 로고    scopus 로고
    • Prolonged thromboprophylaxis with oral anticoagulants after total hip arthroplasty: A prospective controlled randomized study
    • Prandoni P, Bruchi O, Sabbion P, et al. 2002. Prolonged thromboprophylaxis with oral anticoagulants after total hip arthroplasty: a prospective controlled randomized study. Arch. Intern. Med. 162:1966-71
    • (2002) Arch. Intern. Med. , vol.162 , pp. 1966-1971
    • Prandoni, P.1    Bruchi, O.2    Sabbion, P.3
  • 13
    • 18744433904 scopus 로고    scopus 로고
    • Low-molecular-weight heparin prophylaxis using dalteparin extended out-of-hospital vs in-hospital warfarin/out-of-hospital placebo in hip arthroplasty patients: A double-blind, randomized comparison
    • North American Fragmin Trial Investigators
    • Hull RD, Pineo GF, Francis C, et al. 2000. Low-molecular-weight heparin prophylaxis using dalteparin extended out-of-hospital vs in-hospital warfarin/out-of-hospital placebo in hip arthroplasty patients: a double-blind, randomized comparison. North American Fragmin Trial Investigators. Arch. Intern. Med. 160: 2208-15
    • (2000) Arch. Intern. Med. , vol.160 , pp. 2208-2215
    • Hull, R.D.1    Pineo, G.F.2    Francis, C.3
  • 14
    • 0035025096 scopus 로고    scopus 로고
    • Extended thromboprophylaxis with low molecular weight heparin reduces symptomatic venous thromboembolism following lower limb arthroplasty - A meta-analysis
    • Cohen AT, Bailey CS, Alikhan R, Cooper DJ. 2001. Extended thromboprophylaxis with low molecular weight heparin reduces symptomatic venous thromboembolism following lower limb arthroplasty-a meta-analysis. Thromb. Haemost. 85:940-41
    • (2001) Thromb. Haemost. , vol.85 , pp. 940-941
    • Cohen, A.T.1    Bailey, C.S.2    Alikhan, R.3    Cooper, D.J.4
  • 15
    • 0035822248 scopus 로고    scopus 로고
    • Extended-duration prophylaxis against venous thromboembolism after total hip or knee replacement: A meta-analysis of the randomised trials
    • Eikelboom JW, Quinlan DJ, Douketis JD. 2001. Extended-duration prophylaxis against venous thromboembolism after total hip or knee replacement: a meta-analysis of the randomised trials. Lancet 358:9-15
    • (2001) Lancet , vol.358 , pp. 9-15
    • Eikelboom, J.W.1    Quinlan, D.J.2    Douketis, J.D.3
  • 16
    • 0242393499 scopus 로고    scopus 로고
    • Fondaparinux vs. placebo for the prevention of venous thromboembolism in acutely ill medical patients (ARTEMIS)
    • Abstr.
    • Cohen AT, Gallus AS, Lassen MR, et al. 2003. Fondaparinux vs. placebo for the prevention of venous thromboembolism in acutely ill medical patients (ARTEMIS). J. Thromb. Haemost. 1(Suppl. 1):P2046 (Abstr.)
    • (2003) J. Thromb. Haemost. , vol.1 , Issue.SUPPL. 1
    • Cohen, A.T.1    Gallus, A.S.2    Lassen, M.R.3
  • 17
    • 0242560622 scopus 로고    scopus 로고
    • A randomized double-blind study to compare the efficacy and safety of fondaparinux with dalteparin in the prevention of venous thromboembolism after high-risk abdominal surgery: The PEGASUS Study
    • Abstr.
    • Agnelli G, Bergqvist D, Cohen A, et al. 2003. A randomized double-blind study to compare the efficacy and safety of fondaparinux with dalteparin in the prevention of venous thromboembolism after high-risk abdominal surgery: the PEGASUS Study. J. Thromb. Haemost. 1(Suppl. 1):OC006 (Abstr.)
    • (2003) J. Thromb. Haemost. , vol.1 , Issue.SUPPL. 1
    • Agnelli, G.1    Bergqvist, D.2    Cohen, A.3
  • 18
    • 2542424669 scopus 로고    scopus 로고
    • Fondaparinux or enoxaparin for initial treatment of symptomatic deep vein thrombosis: A randomized trial
    • Buller HR, Davidson BL, Decousus H, et al. 2004. Fondaparinux or enoxaparin for initial treatment of symptomatic deep vein thrombosis: a randomized trial. Ann. Intern. Med. 140:867-73
    • (2004) Ann. Intern. Med. , vol.140 , pp. 867-873
    • Buller, H.R.1    Davidson, B.L.2    Decousus, H.3
  • 19
    • 0142182561 scopus 로고    scopus 로고
    • Subcutaneous fondaparinux versus intravenous unfractionated heparin in the initial treatment of pulmonary embolism
    • The MATISSE Investigators. 2003. Subcutaneous fondaparinux versus intravenous unfractionated heparin in the initial treatment of pulmonary embolism. N. Engl. J. Med. 349:1695-702
    • (2003) N. Engl. J. Med. , vol.349 , pp. 1695-1702
  • 20
    • 0003180995 scopus 로고    scopus 로고
    • Meeting highlights - American Heart Association scientific sessions 2001
    • Ferguson JJ. 2002. Meeting highlights-American Heart Association scientific sessions 2001. Circulation 105:e37-e41
    • (2002) Circulation , vol.105
    • Ferguson, J.J.1
  • 21
    • 0034822182 scopus 로고    scopus 로고
    • A synthetic factor-Xa inhibitor (ORG31540/SR9017A) as an adjunct to fibrinolysis in acute myocardial infarction. The PENTALYSE study
    • Coussement PK, Bassand JP, Convens C, et al. 2001. A synthetic factor-Xa inhibitor (ORG31540/SR9017A) as an adjunct to fibrinolysis in acute myocardial infarction. The PENTALYSE study. Eur. Heart J. 22: 1716-24
    • (2001) Eur. Heart J. , vol.22 , pp. 1716-1724
    • Coussement, P.K.1    Bassand, J.P.2    Convens, C.3
  • 22
    • 2642617786 scopus 로고    scopus 로고
    • Biochemical and pharmacological properties of SANORG 34006, a potent and long-acting synthetic pentasaccharide
    • Herbert JM, Herault JP, Bernat A, et al. 1998. Biochemical and pharmacological properties of SANORG 34006, a potent and long-acting synthetic pentasaccharide. Blood 91:4197-205
    • (1998) Blood , vol.91 , pp. 4197-4205
    • Herbert, J.M.1    Herault, J.P.2    Bernat, A.3
  • 23
    • 19944432311 scopus 로고    scopus 로고
    • A novel long-acting synthetic factor Xa inhibitor (SanOrg34006) to replace warfarin for secondary prevention in deep vein thrombosis: A phase II evaluation
    • PERSIST Investigators. 2004. A novel long-acting synthetic factor Xa inhibitor (SanOrg34006) to replace warfarin for secondary prevention in deep vein thrombosis: a phase II evaluation. J. Thromb. Haemost. 2:47-53
    • (2004) J. Thromb. Haemost. , vol.2 , pp. 47-53
  • 24
    • 4644316833 scopus 로고    scopus 로고
    • Initial experience with factor-Xa inhibition in percutaneous coronary intervention: The XaNADU-PCI Pilot
    • Alexander JH, Dyke CK, Yang H, et al. 2004. Initial experience with factor-Xa inhibition in percutaneous coronary intervention: the XaNADU-PCI Pilot. J. Thromb. Haemost. 2:234-41
    • (2004) J. Thromb. Haemost. , vol.2 , pp. 234-241
    • Alexander, J.H.1    Dyke, C.K.2    Yang, H.3
  • 25
    • 11244325810 scopus 로고    scopus 로고
    • A phase II randomized, double-blind, five-arm, parallel-group, dose-response study of a new oral directly-acting factor Xa inhibitor, razaxaban, for the prevention of deep vein thrombosis in knee replacement surgery
    • Abstr.
    • Lassen MR, Davidson BL, Gallus A, et al. 2003. A phase II randomized, double-blind, five-arm, parallel-group, dose-response study of a new oral directly-acting factor Xa inhibitor, razaxaban, for the prevention of deep vein thrombosis in knee replacement surgery. Blood 102:41 (Abstr.)
    • (2003) Blood , vol.102 , pp. 41
    • Lassen, M.R.1    Davidson, B.L.2    Gallus, A.3
  • 26
    • 0033427845 scopus 로고    scopus 로고
    • Replacement therapy with protein C concentrate in infants and adolescents with meningococcal sepsis and purpura fulminans
    • Ettingshausen CE, Veldmann A, Beeg T, et al. 1999. Replacement therapy with protein C concentrate in infants and adolescents with meningococcal sepsis and purpura fulminans. Semin. Thromb. Hemost. 25:537-41
    • (1999) Semin. Thromb. Hemost. , vol.25 , pp. 537-541
    • Ettingshausen, C.E.1    Veldmann, A.2    Beeg, T.3
  • 27
    • 0034548822 scopus 로고    scopus 로고
    • An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia
    • White B, Livingstone W, Murphy C, et al. 2000. An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia. Blood 96:3719-24
    • (2000) Blood , vol.96 , pp. 3719-3724
    • White, B.1    Livingstone, W.2    Murphy, C.3
  • 28
    • 0035826096 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant human activated protein C for severe sepsis
    • Bernard GR, Vincent JL, Laterre PF, et al. 2001. Efficacy and safety of recombinant human activated protein C for severe sepsis. N. Engl. J. Med. 344:699-709
    • (2001) N. Engl. J. Med. , vol.344 , pp. 699-709
    • Bernard, G.R.1    Vincent, J.L.2    Laterre, P.F.3
  • 29
    • 0344775369 scopus 로고    scopus 로고
    • A dose-response study of a recombinant human soluble thrombomodulin (ART-123) for prevention of venous thromboembolism after unilateral total hip replacement
    • Abstr.
    • Kearon C, Comp C, Douketis D, et al. 2003. A dose-response study of a recombinant human soluble thrombomodulin (ART-123) for prevention of venous thromboembolism after unilateral total hip replacement. J. Thromb. Haemost. 1(Suppl. 1): OC330 (Abstr.)
    • (2003) J. Thromb. Haemost. , vol.1 , Issue.SUPPL. 1
    • Kearon, C.1    Comp, C.2    Douketis, D.3
  • 30
    • 0035251672 scopus 로고    scopus 로고
    • The direct thrombin inhibitor melagatran and its oral prodrug H 376/95: Intestinal absorption properties, biochemical and pharmacodynamic effects
    • Gustafsson D, Nystrom JE, Carlsson S, et al. 2001. The direct thrombin inhibitor melagatran and its oral prodrug H 376/95: intestinal absorption properties, biochemical and pharmacodynamic effects. Thromb. Res. 101:171-81
    • (2001) Thromb. Res. , vol.101 , pp. 171-181
    • Gustafsson, D.1    Nystrom, J.E.2    Carlsson, S.3
  • 31
    • 85112365531 scopus 로고    scopus 로고
    • Feiba™ reversed bleeding times prolonged by high doses of a thrombin inhibitor and was not prothrombotic
    • Abstr.
    • Elg M, Borjesson I, Pehrsson S, et al. 2000. Feiba™ reversed bleeding times prolonged by high doses of a thrombin inhibitor and was not prothrombotic. Blood 96:13911 (Abstr.)
    • (2000) Blood , vol.96 , pp. 13911
    • Elg, M.1    Borjesson, I.2    Pehrsson, S.3
  • 32
    • 85112365063 scopus 로고    scopus 로고
    • Melagatran-induced inhibition of thrombin generation is reversed by Feiba™
    • Abstr.
    • Ulvinge J-C, Berntsson P, Bostrom SL. 2000. Melagatran-induced inhibition of thrombin generation is reversed by Feiba™. Blood 96:13917 (Abstr.)
    • (2000) Blood , vol.96 , pp. 13917
    • Ulvinge, J.-C.1    Berntsson, P.2    Bostrom, S.L.3
  • 33
    • 0037048939 scopus 로고    scopus 로고
    • Melagatran for thrombin inhibition in orthopaedic surgery. Ximelagatran and melagatran compared with dalteparin for prevention of venous thromboembolism after total hip or knee replacement: The METHRO II randomised trial
    • Eriksson BI, Bergqvist D, Kalebo P, et al. 2002. Melagatran for thrombin inhibition in orthopaedic surgery. Ximelagatran and melagatran compared with dalteparin for prevention of venous thromboembolism after total hip or knee replacement: the METHRO II randomised trial. Lancet 360:1441-47
    • (2002) Lancet , vol.360 , pp. 1441-1447
    • Eriksson, B.I.1    Bergqvist, D.2    Kalebo, P.3
  • 34
    • 0742284689 scopus 로고    scopus 로고
    • The direct thrombin inhibitor melagatran followed by oral ximelagatran compared with enoxaparin for the prevention of venous thromboembolism after total hip or knee replacement: The EXPRESS study
    • Eriksson BI, Agnelli G, Cohen AT, et al. 2003. The direct thrombin inhibitor melagatran followed by oral ximelagatran compared with enoxaparin for the prevention of venous thromboembolism after total hip or knee replacement: the EXPRESS study. J. Thromb. Haemost. 1:2490-96
    • (2003) J. Thromb. Haemost. , vol.1 , pp. 2490-2496
    • Eriksson, B.I.1    Agnelli, G.2    Cohen, A.T.3
  • 35
    • 0141849427 scopus 로고    scopus 로고
    • Comparison of ximelagatran, an oral direct thrombin inhibitor, with enoxaparin for the prevention of venous thromboembolism following total hip replacement. A randomized, double-blind study
    • Colwell CW, Berkowitz SD, Davidson BL, et al. 2003. Comparison of ximelagatran, an oral direct thrombin inhibitor, with enoxaparin for the prevention of venous thromboembolism following total hip replacement. A randomized, double-blind study. J. Thromb. Haemost. 1:2119-30
    • (2003) J. Thromb. Haemost. , vol.1 , pp. 2119-2130
    • Colwell, C.W.1    Berkowitz, S.D.2    Davidson, B.L.3
  • 36
    • 0142151552 scopus 로고    scopus 로고
    • Comparison of ximelagatran with warfarin for the prevention of venous thromboembolism after total knee replacement
    • Francis CW, Berkowitz SD, Comp PC, et al. 2003. Comparison of ximelagatran with warfarin for the prevention of venous thromboembolism after total knee replacement. N. Engl. J. Med. 349:1703-12
    • (2003) N. Engl. J. Med. , vol.349 , pp. 1703-1712
    • Francis, C.W.1    Berkowitz, S.D.2    Comp, P.C.3
  • 37
    • 1842668759 scopus 로고    scopus 로고
    • Randomized, double-blind comparison of ximelagatran, an oral direct thrombin inhibitor, and warfarin to prevent venous thromboembolism (VTE) after total knee replacement (TKR): EXULTB
    • Abstr.
    • Colwell CW, Berkowitz SD, Comp PC, et al. 2003. Randomized, double-blind comparison of ximelagatran, an oral direct thrombin inhibitor, and warfarin to prevent venous thromboembolism (VTE) after total knee replacement (TKR): EXULTB. Blood 102:14 (Abstr.)
    • (2003) Blood , vol.102 , pp. 14
    • Colwell, C.W.1    Berkowitz, S.D.2    Comp, P.C.3
  • 38
    • 0141636587 scopus 로고    scopus 로고
    • A randomized, controlled, dose-guiding study of the oral direct thrombin inhibitor ximelagatran compared with standard therapy for the treatment of acute deep vein thrombosis: THRIVE I
    • Eriksson H, Wahlander K, Gustafsson D, et al. 2003. A randomized, controlled, dose-guiding study of the oral direct thrombin inhibitor ximelagatran compared with standard therapy for the treatment of acute deep vein thrombosis: THRIVE I. J. Thromb. Haemost. 1:41-47
    • (2003) J. Thromb. Haemost. , vol.1 , pp. 41-47
    • Eriksson, H.1    Wahlander, K.2    Gustafsson, D.3
  • 39
    • 0344775389 scopus 로고    scopus 로고
    • Efficacy and safety of the oral direct thrombin inhibitor ximelagatran compared with current standard therapy for acute symptomatic deep vein thrombosis, with or without pulmonary embolism: A randomized, double-blind, multinational study
    • Abstr.
    • Huisman MV on behalf of the THRIVE Investigators. 2003. Efficacy and safety of the oral direct thrombin inhibitor ximelagatran compared with current standard therapy for acute symptomatic deep vein thrombosis, with or without pulmonary embolism: a randomized, double-blind, multinational study. J. Thromb. Haemost. 1(Suppl. 1):OC003 (Abstr.)
    • (2003) J. Thromb. Haemost. , vol.1 , Issue.SUPPL. 1
    • Huisman, M.V.1
  • 40
    • 0142182558 scopus 로고    scopus 로고
    • Secondary prevention of venous thromboembolism with the oral direct thrombin inhibitor ximelagatran
    • Schulman S, Wahlander K, Lundstrom T, et al.; THRIVE III Investigators. 2003. Secondary prevention of venous thromboembolism with the oral direct thrombin inhibitor ximelagatran. N. Engl. J. Med. 349:1713-21
    • (2003) N. Engl. J. Med. , vol.349 , pp. 1713-1721
    • Schulman, S.1    Wahlander, K.2    Lundstrom, T.3
  • 41
    • 0038185371 scopus 로고    scopus 로고
    • Ximelagatran versus warfarin for stroke prevention in patients with non-valvular atrial fibrillation. SPORTIF II: A dose-guiding, tolerability, and safety study
    • Petersen P, Grind M, Adler J; SPORTIF II Investigators. 2003. Ximelagatran versus warfarin for stroke prevention in patients with non-valvular atrial fibrillation. SPORTIF II: a dose-guiding, tolerability, and safety study. J. Am. Coll. Cardiol. 41:1445-51
    • (2003) J. Am. Coll. Cardiol. , vol.41 , pp. 1445-1451
    • Petersen, P.1    Grind, M.2    Adler, J.3
  • 42
    • 0041694480 scopus 로고    scopus 로고
    • Ximelagatran compared with warfarin for prevention of thromboembolism in patients with nonvalvular atrial fibrillation: Rationale, objectives, and design of a pair of clinical studies and baseline patient characteristics (SPORTIF III and V)
    • Halperin JL; Executive Steering Committee, SPORTIF III and V Study Investigators. 2003. Ximelagatran compared with warfarin for prevention of thromboembolism in patients with nonvalvular atrial fibrillation: rationale, objectives, and design of a pair of clinical studies and baseline patient characteristics (SPORTIF III and V). Am. Heart J. 146:431-38
    • (2003) Am. Heart J. , vol.146 , pp. 431-438
    • Halperin, J.L.1
  • 43
    • 0345414673 scopus 로고    scopus 로고
    • Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): Randomised controlled trial
    • Olsson SB; SPORTIF III Investigators. 2003. Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): randomised controlled trial. Lancet 362:1691-98
    • (2003) Lancet , vol.362 , pp. 1691-1698
    • Olsson, S.B.1
  • 45
    • 0041829444 scopus 로고    scopus 로고
    • Oral ximelagatran for secondary prophylaxis after myocardial infarction: The ESTEEM randomised controlled trial
    • Wallentin L, Wilcox R, Weaver D, et al. 2003. Oral ximelagatran for secondary prophylaxis after myocardial infarction: the ESTEEM randomised controlled trial. Lancet 362:789-97
    • (2003) Lancet , vol.362 , pp. 789-797
    • Wallentin, L.1    Wilcox, R.2    Weaver, D.3
  • 46
    • 0141750717 scopus 로고    scopus 로고
    • Oral direct thrombin inhibitors in clinical development
    • Gustafsson D. 2003. Oral direct thrombin inhibitors in clinical development. J. Intern. Med. 254:322-34
    • (2003) J. Intern. Med. , vol.254 , pp. 322-334
    • Gustafsson, D.1
  • 47


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