In vitro and in vivo evaluation of oral heparin-loaded polymeric nanoparticles in rabbits

Circulation

Volumn 105, Issue 2, 2002, Pages 230-235

  Jiao, Yuyan ^a   Ubrich, Nathalie ^a   Marchand Arvier, Monique ^a   Vigneron, Claude ^a   Hoffman, Maurice ^a   Lecompte, Thomas ^a   Maincent, Philippe ^a  

^a UNIVERSITÉ DE LORRAINE   (France)

Author keywords

Anticoagulants; Drugs; Heparin; Nanoparticles

Indexed keywords

ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 10A; HEPARIN; NANOPARTICLE; POLYCAPROLACTONE; POLYGLACTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOAVAILABILITY; BIODEGRADATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; GASTROINTESTINAL ABSORPTION; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PEYER PATCH; POLYMERIZATION; PRIORITY JOURNAL; RABBIT;

ACRYLIC RESINS; ADMINISTRATION, ORAL; ANIMALS; ANTICOAGULANTS; DRUG DELIVERY SYSTEMS; FACTOR XA; GLYCOLATES; HEPARIN; HEXANOIC ACIDS; INTESTINAL ABSORPTION; KINETICS; LACTONES; MALE; MICROSPHERES; NANOTECHNOLOGY; PARTIAL THROMBOPLASTIN TIME; POLYMERS; RABBITS;

EID: 0037080913     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/hc0202.101988     Document Type: Article

References (20)

1. Biodegradable nanoparticles for subcutaneous administration of growth hormone releasing factor (hGRF)
2. Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles
3. Recombinant human growth hormone poly(lactic-co-glycolic acid) (PLGA) microspheres provide a long lasting effect
4. Transmucosal passage of polyalkylcyanoacrylate nanocapsules as a new drug carrier in the small intestine
5. The uptake and translocation of latex nanospheres and microspheres after oral administration to rats
6. Nanocapsules as carriers for oral peptides delivery
7. Comparison of poly(DL-lactide-co-glycolide) and polystyrene microsphere targeting to intestinal M-cells
8. New approach for oral administration of insulin with polyalkylcyanoacrylate nanocapsules as drug carriers
9. The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration
10. Heparin and low-molecular-weight-heparin
11. Olive oil-provoked, bile-dependent absorption of heparin from the gastrointestinal tract in rats
12. Oral administration of liposomally-entrapped heparin to beagle dogs
13. Acylated non-α-amino acids as novel agents for the oral delivery of heparin sodium, USP
14. Oral delivery of anticoagulant doses of heparin: A randomised, double-blind, controlled study in humans
15. Biodegradable monodispersed nanoparticles prepared by pressure homogenization-emulsification
16. The separation of active and inactive forms of heparin
17. Control of the biodegradation rate of poly(DL-lactide) microparticles intended as chemoembolization materials
18. The preparation and acute antihypertensive effects of a nanocapsular form of darodipine, a dihydropyridine calcium entry blocker
19. Intestinal absorption of low molecular weight heparin in animals and human subjects
20. Pharmacokinetics and distribution of a biodegradable drug-carrier