Heparin absorption across the intestine: Effects of sodium N-[8-(2- hydroxybenzoyl)amino]caprylate in rat in situ intestinal instillations and in Caco-2 monolayers

Pharmaceutical Research

Volumn 14, Issue 12, 1997, Pages 1772-1779

  Brayden, David ^a   Creed, Elizabeth ^a   O'Connell, Alan ^a   Leipold, Harry ^b   Agarwal, Rajesh ^b   Leone Bay, Andrea ^b  

^a ELAN PHARMACEUTICALS   (United States)

^b Emisphere Technologies Inc   (United States)

Author keywords

Amido acid; Caco 2; Heparin absorption; Rat intestinal instillation

Indexed keywords

ANTIBODY; BLOOD CLOTTING FACTOR 10A; HEPARIN; N [8 (2 HYDROXYBENZOYL)AMINO]CAPRYLATE; OCTANOIC ACID DERIVATIVE; PROPYLENE GLYCOL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL STRAIN CACO 2; COLON; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ADMINISTRATION; DRUG TRANSPORT; FEMALE; HEPARINIZATION; HUMAN; HUMAN CELL; ILEUM; INTESTINE ABSORPTION; MALE; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PASSIVE TRANSPORT; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; TRANSCYTOSIS;

ANIMALS; CACO-2 CELLS; CAPRYLATES; CELL SURVIVAL; COLON; FEMALE; HEPARIN; HUMANS; ILEUM; INTESTINAL ABSORPTION; MALE; PARTIAL THROMBOPLASTIN TIME; PROPYLENE GLYCOL; RATS;

EID: 0031422605     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012192115828     Document Type: Article

References (29)

1. M. Koopman, P. Prandoni, F. Piovella, P. Ockelford, D. Brandjes, M. Van der Meer, A. Gallus, C. Chesterman, M. Prins, P. Bossuyt, H. de Haes, A. Van den Belt, L. Sagnard, P. D'Azemar, and H. M. Buller. N. Engl. J. Med., 334:682-687 (1996).
2. R. D. Hull, G. E. Raskob, G. F. Pineo, D. Green, A. A. Trowbridge, C. G. Elliott, R. G. Lerner, J. Hall, T. Sparling, H. R. Brettell, J. Norton, C. J. Carter, R. George, G. Merli, J. Ward, W. Mayo, D. Rosenbloom, and R. Brant. N. Engl. J. Med., 326:975-982 (1992).
3. J. B. Hardman and L. E. Limbird. In: The Pharmacological Basis of Therapeutics. Ed. L. S. Goodman and A. Gilman. 9th Edition, McGraw-Hill, New York, pp. 1343-1346, 1996.
4. R. Hull, T. Delmore, C. Carter, J. Hirsh, E. Genton, M. Gent, G. Turpie, and D. McLaughlin. N. Engl. J. Med., 306:189-194 (1982).
5. K. A. Jandik, D. Kruep, M. Cartier, and R. J. Lindhardt. J. Pharm. Sci., 85:45-51 (1996).
6. V. H. L. Lee and A. Yamamoto. Adv. Drug Del. Rev., 4:171-207 (1990).
7. A. Leone-Bay, H. Leipold, D. Sarubbi, B. Variano, T. Rivera, and R. A. Baughman. Pharm. Res., 13:222-226 (1996).
8. A. Leone-Bay, N. Santiago, D. Achan, K. Chaudhary, F. DeMorin, L. Falzarano, S. Haas, S. Kalbag, D. Kaplan, H. Leipold, C. Lercara, D. O'Toole, T. Rivera, C. Rosado, D. Sarubbi, E. Vuocolo, N. Wang, S. Milstein, and R. A. Baughman. J. Med. Chem., 38:4263-4269 (1995).
9. A. Leone-Bay, K. K. Ho, R. Agarwal, R. A. Baughman, K. Chaudhary, F. DeMorin, L. Grenoble, C. McInnes, D. Sarubbi, B. Variano, and D. C. Paton. J. Med. Chem., 13:2571-2578 (1996).
10. A. Leone-Bay, D. R. Paton, B. Variano, H. Leipold, T. Rivera, J. Miura-Fraboni, R. A. Baughman, and N. Santiago. J. Contr. Rel., In Press. (1997).
11. R. Agarwal, K. Chaudhary, E. Barantsevich, E. Harris, K.-K Ho, and R. A. Baughman. Pharm. Res., 13:S280 (1996).
12. A. Leone-Bay, C. McInnes, N. Wang, F. DeMorin, D. Achan, C. Lercara, D. Sarubbi, S. Haas, J. Press, E. Barantsevich, B. O'Broin, S. Milstein, and D. Paton. J. Med. Chem., 38:4257-4262 (1995).
13. S. Steiner and R. Rosen. U. S. Patent, 4,925,673 (1990).
14. J. T. Doluisio, N. F. Billups, L. W. Dittert, E. T. Sugita, and J. V. Swintosky. J. Pharm. Sci., 58:1196-1200 (1969).
15. P. Artursson. J. Pharm. Res., 79:476-482 (1990).
16. P. Artursson, J. Karlsson, G. Ocklind, and N. Schipper. In: Epithelial cell culture, a practical approach. Ed. A. J. Shaw. IRL Press, Oxford, UK. Chapter 6, pp. 111-133, 1996.
17. J. B. Henry. Clinical Diagnosis and Management by Laboratory Methods. W. B. Saunders, Philadelphia, 1979.
18. S. A. Riley, G. Warhurst, P. T. Crowe, and L. A. Turnberg. Biochem. Biophys. Acta. 1066:175-182 (1991)
19. B. H. Stewart, O. H. Chan, R. H. Lu, E. L. Reyner, H. L. Schmid, H. W. Hamilton, B. A. Steinbaugh, and M. D. Taylor. Pharm. Res., 12:693-699 (1995).
20. C. D. Marci and D. Prager. Am. J. Clinical Pathol., 99:546-550 (1993).
21. In: Handbook of Pharmaceutical Excipients. 2nd Edition. Ed. A. Wade and P. J. Weller. Pharmaceutical Press (London). pp. 407-408, 1994.
22. L. Lohikangas, M. Wilen, M Einarsson, and P. Artursson. Eur. J. Pharm. Sci., 1:307-312 (1994).
23. L. M. Hiebert, S. M. Wice, N. M. McDuffie, and L. B. Jacques. Quart. J. Med., 86:341-348 (1993).
24. E. K. Anderberg and P. Artursson. In: Drug absorption enhancement concepts, limitations and trends. Ed. A. G. de Boer. Harwood Press, pp 101-118 (1994).
25. T. T. Karlarli. Biopharm. and Drug Disposition, 16:351-380 (1995).
26. D. J. Brayden. Pharm. News, 4:11-15 (1997).
27. T. Nishihata, J. H. Rytting, A. Kamada, and T. Higuchi. Diabetes, 30:1065-1067 (1981).
28. E. Touitou, F. Alhaique, P. Fisher, A. Memoli, F. M. Riccieri, and E. Santucci. J. Pharm. Sci., 76:791-793 (1987).
29. A. Leone-Bay, H. Leipold, D. Paton, S. Milstein, and R. Baughman. Drug News Persp., 9:586-591 (1996).