Antithrombotic activity of oral unfractionated heparin

Journal of Cardiovascular Pharmacology

Volumn 28, Issue 1, 1996, Pages 26-29

  Hiebert, Linda M ^a   Wice, Sandra M ^a   Jaques, Louis B ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Activated partial thromboplastin time; Endothelium; Heparin; Oral; Rats; Thrombosis

Indexed keywords

HEPARIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; BLOOD CLOT LYSIS; CONTROLLED STUDY; DOSE LIVER FUNCTION RELATION; DOSE RESPONSE; DRUG ABSORPTION; ENDOTHELIUM CELL; NONHUMAN; ORAL DRUG ADMINISTRATION; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; RAT; THROMBOCYTE AGGREGATION; VASCULAR ENDOTHELIUM;

ADMINISTRATION, ORAL; ANIMALS; ANTICOAGULANTS; ENDOTHELIUM, VASCULAR; HEPARIN; MALE; PARTIAL THROMBOPLASTIN TIME; RATS; RATS, WISTAR; THROMBOSIS;

EID: 0029952488     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199607000-00005     Document Type: Article

References (10)

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2. Blake OR, Ashwin JG, Jaques LB. An assay for the antithrombotic activity of anticoagulants. J Clin Pathol 1959;12:118-22.
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4. Jaques LB, Wice SM, Hiebert LM. Determination of absolute amounts of heparin and of dextran sulfate in plasma in microgram quantities. J Lab Clin Med 1990;115:422-32.
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7. Ashwin JG. The effect of drugs on experimental thrombogenesis. In: MacMillan RL, Mustard JF, eds. Anticoagulants and fibrinolysis. Toronto: Macmillan of Canada. 1961:117-27.
8. Jaques LB. The chemistry, pharmacology and assay of heparin. Thromb Diath Haemost 1963;9(suppl 2):27-36.
9. Ashwin GJ, Jaques LB: The effect of phosphorus 32, dextran, reserpine, and stypturon on thrombus formation in rats. Thromb Diath Haemost 1961;5:543-52.
10. Hiebert LM, Wice SM, McDuffie NM, Jaques LB. The heparin target organ - the endothelium. Studies in a rat model. Q J Med 1993;86:341-8.