Mono-N-carboxymethyl chitosan (MCC), a polyampholytic chitosan derivative, enhances the intestinal absorption of low molecular weight heparin across intestinal epithelia in vitro and in vivo

Journal of Pharmaceutical Sciences

Volumn 90, Issue 1, 2001, Pages 38-46

  Thanou, M ^a   Nihot, M T ^a   Jansen, M ^a   Verhoef, J C ^a   Junginger, H E ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Caco 2 cells; Intraduodenal administration; Low molecular weight heparin; Mono N carboxymethyl chitosan; Rats

Indexed keywords

AMPHOLYTE; CHITOSAN DERIVATIVE; LOW MOLECULAR WEIGHT HEPARIN;

ANIMAL EXPERIMENT; ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG SYNTHESIS; DRUG TRANSPORT; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; INTESTINE EPITHELIUM; MALE; NONHUMAN; RAT; VISCOSITY;

EID: 0035171635     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/1520-6017(200101)90:1<38::AID-JPS5>3.0.CO;2-3     Document Type: Article

References (19)

1. Pharmaceutical applications of chitosan
2. Oral gene delivery with chitosan-DNA nanoparticles generates immunologic protection in a murine model of peanut allergy
3. Chitosan as a novel nasal delivery system for peptide drugs
4. N-Trimethylated chitosan chloride (TMC) improves the intestinal permeation of the peptide drug buserelin in vitro (Caco-2 cells) and in vivo (rats)
5. Chitosans as absorption enhancers for poorly absorbable drugs. 2. Mechanism of absorption enhancement
6. Intestinal peptide and protein delivery: Novel bioadhesive drug-carrier matrix shielding from enzymatic attack
7. Novel synthesis of a water-soluble cyclodextrin-polymer having a chitosan skeleton
8. Aggregation phenomenon of PEG-grafted chitosan in aqueous solution
9. Effects of N-trimethyl chitosan chloride, a novel absorption enhancer, on Caco-2 intestinal epithelia and the ciliary beat frequency of chicken embryo trachea
10. N-Carboxymethylidene)-chitosans and N-(carboxymethyl)-chitosans: Novel chelating polyampholytes obtained from chitosan glyoxylate
11. Effect of degree of quaternization of N-trimethyl chitosan chloride for enhanced transport of hydrophilic compounds across intestinal Caco-2 cell monolayers
12. Establishing an institution-specific therapeutic range for heparin
13. Macromolecules as safe penetration enhancers for hydrophilic drugs - A fiction?
14. Future alternatives to heparin: Low-molecular-weight heparin and hirudin
15. Low-molecular-weight heparin: Prophylaxis and treatment of venous thromboembolism
16. Oral low-molecular weight heparin and delivery agent prevents jugular venous thrombosis in the rat
17. Heparin absorption across the intestine: Effects of sodium N-[8-(2hydroxybenzoyl)amino]caprylate in rat in situ intestinal instillations and in Caco-2 monolayers
18. Acylated non-alpha-amino acids as novel agents for the oral delivery of heparin sodium, USP
19. Synthesis and evaluation of compounds that facilitate the gastrointestinal absorption of heparin