TOR signaling in mammals

Journal of Cell Science

Volumn 117, Issue 20, 2004, Pages 4615-4616

  Carrera, Ana C ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINO ACID; BINDING PROTEIN; ELONGATION FACTOR; GROWTH FACTOR; GUANOSINE TRIPHOSPHATASE; HAMARTIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INITIATION FACTOR 4E; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; POLYPYRIMIDINE TRACT BINDING PROTEIN; PROTEIN KINASE B; PROTEIN S6; PROTEIN SERINE THREONINE KINASE; RIBOSOME PROTEIN; S6 KINASE; TARGET OF RAPAMYCIN KINASE; TUBERIN;

CELL GROWTH; EDITORIAL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; MAMMAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RNA CAPPING; RNA TRANSLATION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ENZYME ACTIVATION; MULTIPROTEIN COMPLEXES; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 7244261884     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.01311     Document Type: Editorial

References (15)

1. Alvarez, B., Garrido, E., Garcia-Sanz, J. A and Carrera, A. C. (2003). Phosphoinositide 3-kinase activation regulates cell division time by coordinated control of cell mass and cell cycle progression rate. J. Biol. Chem. 278, 26466-26473.
2. Chen, E. J. and Kaiser, C. A. (2003). LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway. J. Cell Biol. 161, 333-347.
3. Dufner, A. and Thomas, G. (1999) Ribosomal S6 kinase signaling and the control of translation. Exp Cell Res. 253, 100-109.
4. Gao, X., Zhang, Y., Arrazola, P., Hino, O., Kobayashi, T., Yeung, R. S., Ru, B. and Pan, D. (2002). Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nat. Cell Biol. 4 699-704.
5. Gingras, A. C., Raught, B. and Sonenberg, N. (2004). mTOR signaling to translation. Curr. Top. Microbiol. Immunol. 279, 169-197.
6. Gonzalez-Garcia, A., Garrido, E., Hernandez, C., Alvarez, B., Jimenez, C., Cantrell, D. A., Pullen, N. and Carrera, A. C. (2002). A new role for the p85-phosphatidylinositol 3-kinase regulatory subunit linking FRAP to p70 S6 kinase activation. J. Biol. Chem. 277, 1500-1508.
7. Hara, K., Maruki, Y., Long, X., Yoshino, K., Oshiro, N., Hidayat, S., Tokunaga, C., Avruch, J. and Yonezawa, K. (2002). Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 110, 177-189.
8. Inoki, K., Li, Y., Zhu, T., Wu, J., Guan, K. L. (2002) TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4, 648-657.
9. Inoki, K., Zhu, T. and Guan, K. L. (2003). TSC2 mediates cellular energy response to control cell growth and survival. Cell 115, 577-590.
10. Kim, D. H., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument-Bromage, H., Tempst, P. and Sabatini, D. M. (2002). mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110, 163-175.
11. Manning, B. D. and Cantley, L. C. (2003). Rheb fills a GAP between TSC and TOR. Trends Biochem. Sci. 28, 573-576.
12. Potter, C. J., Pedraza, L. G., Huang, H. and Xu, T. (2003). The tuberous sclerosis complex (TSC) pathway and mechanism of size control. Biochem. Soc. Trans. 31, 584-586.
13. Romanelli, A., Dreisbach, V. C. and Blenis, J. (2002). Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1. J. Biol. Chem. 277, 40281-40289.
14. Schmelzle, T. and Hall, M. N. (2000). TOR, a central controller of cell growth. Cell 103, 253-262.
15. Stolovich, M., Tang, H., Hornstein, E., Levy, G., Cohen, R., Bae, S. S., Birnbaum, M. J. and Meyuhas, O. (2002). Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation. Mol. Cell. Biol. 22, 8101-8113.