The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death

Molecular Cell

Volumn 7, Issue 6, 2001, Pages 1307-1319

  Karuman, Philip ^a   Gozani, Or ^a   Odze, Robert D ^b   Zhou, Xun Clare ^a   Zhu, Hong ^a   Shaw, Reuben ^a,c   Brien, Tom P ^b   Bozzuto, Christopher D ^a   Ooi, Danny ^a   Cantley, Lewis C ^a,c   Yuan, Junying ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; GENE PRODUCT LKB1; MUTANT PROTEIN; PROTEIN P53; PROTEIN SERINE KINASE; THREONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BENIGN TUMOR; CARCINOGENESIS; CELL DEATH; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; ENZYME REGULATION; FIBROSARCOMA; GENE TRANSLOCATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; INTESTINE EPITHELIUM CELL; INTESTINE POLYP; MALIGNANT NEOPLASTIC DISEASE; MITOCHONDRION; MOUSE; NONHUMAN; PEUTZ JEGHERS SYNDROME; PROTEIN LOCALIZATION; RAT; SMALL INTESTINE;

ANIMALIA;

EID: 0034964446     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00258-1     Document Type: Article

References (39)

1. p53 in signaling checkpoint arrest or apoptosis
2. Raf-1/bcl-2 phosphorylation: A step from microtubule damage to cell death
3. p53 is associated with cellular microtubules and is transported to the nucleus by dynein
4. Increased risk of cancer in the Peutz-Jeghers syndrome
5. BCL-2 family members and the mitochondria in apoptosis
6. Inactivation of Bcl-2 by phosphorylation
7. Taxol induces bcl-2 phosphorylation and death of prostate cancer cells
8. The hallmarks of cancer
9. Protein kinases 6. The eukaryotic protein kinase superfamily: Kinase (catalytic) domain structure and classification
10. Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis
11. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome
12. Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits: A syndrome of disgnostic significance
13. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase
14. Bax-deficient mice with lymphoid hyperplasia and male germ cell death
15. Viability of wild type p53-containing and p53-deficient tumor cells following anticancer treatment: The use of human papillomavirus E6 to target p53
16. p53-Independent apoptosis induced by paclitaxel through an indirect mechanism
17. Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: Role of a caspase cascade
18. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
19. p53 is required for radiation-induced apoptosis in mouse thymocytes
20. Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling
21. Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity
22. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice
23. Differential expression of bcl-2 in intestinal epithelia. Correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia
24. Kinetics of mitotic arrest and apoptosis in murine mammary and ovarian tumors treated with taxol
25. Nine novel germline mutations of STK11 in ten families with Peutz-Jeghers syndrome
26. CD95 (Fas/APO-1) and p53 signal apoptosis independently in diverse cell types
27. Peutz-Jeghers disease: Most, but not all, families are compatible with linkage to 19p13.3
28. On a very remarkable case of familial polyposis of the mucous membrane of the intestinal tract and nasopharynx accompanied by peculiar pigmentation of the skin and mucous membrane
29. The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice
30. Epithelial cell growth and differentiation. II. Intestinal apoptosis
31. The development and clinical utility of the taxane class of antimicrotubule chemotherapy agents
32. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
33. The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase
34. Cancer and the Peutz-Jeghers syndrome
35. In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system
36. Cloning and characterization of a novel serine/threonine protein kinase expressed in early Xenopus embryos
37. Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest
38. P53 and β catenin expression in chronic ulcerative colitis - Associated polypoid dysplasia and sporadic adenomas: An immunohistochemical study
39. Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways