Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 15, 2006, Pages 5357-5369

  Zbinden, Katrin Groebke ^a   Banner, David W ^a   Hilpert, Kurt ^a   Himber, Jacques ^a   Lavé, Thierry ^a   Riederer, Markus A ^a   Stahl, Martin ^a   Tschopp, Thomas B ^a   Obst Sander, Ulrike ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Anticoagulant; Bleeding time prolongation; Coagulation cascade; Double prodrug; Tissue factor factor VIIa inhibitor

Indexed keywords

BLOOD CLOTTING FACTOR 7A INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTERY THROMBOSIS; ARTICLE; BEHAVIOR; BLEEDING; BLEEDING TIME; DOSE RESPONSE; DRUG EFFECT; GUINEA PIG; NONHUMAN;

ADMINISTRATION, ORAL; ANIMALS; ANTICOAGULANTS; BLEEDING TIME; BLOOD COAGULATION FACTOR INHIBITORS; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; FACTOR VIIA; GUINEA PIGS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PRODRUGS; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBOPLASTIN; THROMBOSIS;

CAVIA PORCELLUS;

EID: 33745123371     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.03.042     Document Type: Article

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