메뉴 건너뛰기




Volumn 19, Issue 4, 2003, Pages 222-228

Ximelagatran: A new era in oral anticoagulation

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; DALTEPARIN; ENOXAPARIN; MELAGATRAN; THROMBIN INHIBITOR; WARFARIN; XIMELAGATRAN;

EID: 0038043582     PISSN: 87551225     EISSN: None     Source Type: Journal    
DOI: 10.1177/875512250301900304     Document Type: Review
Times cited : (5)

References (35)
  • 1
    • 0037178001 scopus 로고    scopus 로고
    • Births, marriages, divorces, and deaths: Provisional data for September 2001
    • National Center for Health Statistics. Births, marriages, divorces, and deaths: provisional data for September 2001. Natl Vital Stat Rep 2002;50(8):1-3.
    • (2002) Natl Vital Stat Rep , vol.50 , Issue.8 , pp. 1-3
  • 2
    • 0002528851 scopus 로고    scopus 로고
    • Prevention of major bleeding in older patients treated with warfarin: Results of a randomized trial
    • Beyth RJ, Landefeld CS. Prevention of major bleeding in older patients treated with warfarin: results of a randomized trial (abstract). J Gen Intern Med 1997;12:66.
    • (1997) J Gen Intern Med , vol.12 , pp. 66
    • Beyth, R.J.1    Landefeld, C.S.2
  • 3
    • 0001563444 scopus 로고    scopus 로고
    • Identification and surveillance of patients on oral anticoagulation therapy in a large geographical area - Use of laboratory information systems
    • Holm T, Lassen JF, Husted SE. Identification and surveillance of patients on oral anticoagulation therapy in a large geographical area - use of laboratory information systems. Thromb Haemost 1999;82(suppl):858-9.
    • (1999) Thromb Haemost , vol.82 , Issue.SUPPL. , pp. 858-859
    • Holm, T.1    Lassen, J.F.2    Husted, S.E.3
  • 6
    • 0036007936 scopus 로고    scopus 로고
    • Inhibition of thrombin generation by the oral direct thrombin inhibitor ximelagatran in shed blood from healthy male subjects
    • Sarich TC, Eriksson UG, Mattsson C, Wolzt M, Frison L, Fager G, et al. Inhibition of thrombin generation by the oral direct thrombin inhibitor ximelagatran in shed blood from healthy male subjects (abstract). Thromb Haemost 2002;87:300-5.
    • (2002) Thromb Haemost , vol.87 , pp. 300-305
    • Sarich, T.C.1    Eriksson, U.G.2    Mattsson, C.3    Wolzt, M.4    Frison, L.5    Fager, G.6
  • 7
    • 85112360116 scopus 로고    scopus 로고
    • Inhibition of thrombin-induced platelet activation by different anticoagulants as measured with flow cytometry
    • Nylander S, Mattsson C. Inhibition of thrombin-induced platelet activation by different anticoagulants as measured with flow cytometry (abstract). Blood 2000;96(11 pt 2):50b.
    • (2000) Blood , vol.96 , Issue.11 PART 2
    • Nylander, S.1    Mattsson, C.2
  • 8
    • 0008464808 scopus 로고    scopus 로고
    • Effect of melagatran, the active form of the oral direct thrombin inhibitor, H 376/95, on platelet deposition and relative thrombus size in a porcine, coronary artery ober-stretch injury model
    • Schersten F, Wahlund G, Carlsson S, Mattsson C, Grip L. Effect of melagatran, the active form of the oral direct thrombin inhibitor, H 376/95, on platelet deposition and relative thrombus size in a porcine, coronary artery ober-stretch injury model (abstract). Circulation 2000;102(suppl II):II-130.
    • (2000) Circulation , vol.102 , Issue.SUPPL. II
    • Schersten, F.1    Wahlund, G.2    Carlsson, S.3    Mattsson, C.4    Grip, L.5
  • 9
    • 0033135457 scopus 로고    scopus 로고
    • Antithrombotic effects and bleeding time of thrombin inhibitors and warfarin in the rat
    • Elg M, Gustafsson D, Carlsson S. Antithrombotic effects and bleeding time of thrombin inhibitors and warfarin in the rat. Thromb Res 1999;94:187-97.
    • (1999) Thromb Res , vol.94 , pp. 187-197
    • Elg, M.1    Gustafsson, D.2    Carlsson, S.3
  • 10
    • 0037663607 scopus 로고    scopus 로고
    • A comparison of ximelagatran and warfarin on thrombus size during phophylaxis of a vena cava thrombosis in the anesthetized rat
    • Orlando, FL, December 7-11
    • Carlsson S, Elg M. A comparison of ximelagatran and warfarin on thrombus size during phophylaxis of a vena cava thrombosis in the anesthetized rat (abstract). Presented at: American Society of Hematology 43rd Annual Meeting, Orlando, FL, December 7-11, 2001.
    • (2001) American Society of Hematology 43rd Annual Meeting
    • Carlsson, S.1    Elg, M.2
  • 11
    • 85085587926 scopus 로고    scopus 로고
    • Mild-to-moderate liver impairment has no influence on the pharmacokinetics of ximelagatran, an oral direct thrombin inhibitor
    • Eriksson UG, Eriksson LM, Ohlsson L, Wåhlander K. Mild-to-moderate liver impairment has no influence on the pharmacokinetics of ximelagatran, an oral direct thrombin inhibitor (abstract). Clin Pharmacol Ther 2002;71:P99.
    • (2002) Clin Pharmacol Ther , vol.71
    • Eriksson, U.G.1    Eriksson, L.M.2    Ohlsson, L.3    Wåhlander, K.4
  • 12
    • 85112368229 scopus 로고    scopus 로고
    • A comparison of the pharmacokinetics of ximelagatran in young and elderly healthy subjects
    • Johansson LC, Eriksson UG, Frison L, Fager G. A comparison of the pharmacokinetics of ximelagatran in young and elderly healthy subjects (abstract). Blood 2000;96(11 pt 1):57a.
    • (2000) Blood , vol.96 , Issue.11 PART 1
    • Johansson, L.C.1    Eriksson, U.G.2    Frison, L.3    Fager, G.4
  • 13
    • 85112372415 scopus 로고    scopus 로고
    • The impact of ethnic origin on the pharmacokinetics of orally administered ximelagatran
    • Johansson LC, Eriksson UG, Frison L, Fager G. The impact of ethnic origin on the pharmacokinetics of orally administered ximelagatran (abstract). Blood 2000;96(11 pt 1):56a.
    • (2000) Blood , vol.96 , Issue.11 PART 1
    • Johansson, L.C.1    Eriksson, U.G.2    Frison, L.3    Fager, G.4
  • 14
    • 0038436878 scopus 로고    scopus 로고
    • Comparison of the pharmacokinetics of ximelagatran, an oral direct thrombin inhibitor, in patients with nonvalvular atrial fibrillation and elderly healthy subjects
    • Eriksson UG, Wollbratt M, Wolzt M, Svensson M, Grind M. Comparison of the pharmacokinetics of ximelagatran, an oral direct thrombin inhibitor, in patients with nonvalvular atrial fibrillation and elderly healthy subjects (abstract). Clin Pharmacol Ther 2002; 71:P95.
    • (2002) Clin Pharmacol Ther , vol.71
    • Eriksson, U.G.1    Wollbratt, M.2    Wolzt, M.3    Svensson, M.4    Grind, M.5
  • 15
    • 0038230251 scopus 로고    scopus 로고
    • Pharmacokinetics of melagatran after oral dosing with ximelagatran, a direct thrombin inhibitor, in patients with acute venous thromboembolism (VTE)
    • Cullberg M, Eriksson H, Eriksson UG, Frison L, Karlsson MO, Schulman S, et al. Pharmacokinetics of melagatran after oral dosing with ximelagatran, a direct thrombin inhibitor, in patients with acute venous thromboembolism (VTE) (abstract). Clin Pharmacol Ther 2002;71:P61.
    • (2002) Clin Pharmacol Ther , vol.71
    • Cullberg, M.1    Eriksson, H.2    Eriksson, U.G.3    Frison, L.4    Karlsson, M.O.5    Schulman, S.6
  • 16
    • 33748536732 scopus 로고    scopus 로고
    • Pharmacokinetics of melagatran, the active form of the oral, direct thrombin inhibitor H376/95, in orthopaedic surgery patients treated to prevent deep vein thrombosis and pulmonary embolism
    • Eriksson UG, Frisson L, Gustafsson D, Mandema J, Karlsson MO, Eriksson B. Pharmacokinetics of melagatran, the active form of the oral, direct thrombin inhibitor H376/95, in orthopaedic surgery patients treated to prevent deep vein thrombosis and pulmonary embolism (abstract). Blood 2000;96(11 Part 2):93b.
    • (2000) Blood , vol.96 , Issue.11 PART 2
    • Eriksson, U.G.1    Frisson, L.2    Gustafsson, D.3    Mandema, J.4    Karlsson, M.O.5    Eriksson, B.6
  • 17
    • 0009879613 scopus 로고    scopus 로고
    • Lack of an effect of obesity on the pharmacokinetics and pharmacodynamics of melagatran after oral administration of ximelagatran
    • Orlando, Florida. December 7-11
    • Sarich TC, Teng R, Peters G, Wollbratt M, Homolka B, Svensson M, et al. Lack of an effect of obesity on the pharmacokinetics and pharmacodynamics of melagatran after oral administration of ximelagatran (abstract). American Society of Hematology 43rd Annual Meeting. Orlando, Florida. December 7-11, 2001.
    • (2001) American Society of Hematology 43rd Annual Meeting
    • Sarich, T.C.1    Teng, R.2    Peters, G.3    Wollbratt, M.4    Homolka, B.5    Svensson, M.6
  • 19
  • 20
    • 23544464222 scopus 로고    scopus 로고
    • Ximelagatran, an oral direct thrombin inhibitor, has no effect on the pharmacokinetics of P450-metabolized drugs
    • Johansson S, Eriksson LM, Thuresson A, Larsson M, Frison L, Bylock A, et al. Ximelagatran, an oral direct thrombin inhibitor, has no effect on the pharmacokinetics of P450-metabolized drugs (abstract). Clin Pharmacol Ther 2002;71:P65.
    • (2002) Clin Pharmacol Ther , vol.71
    • Johansson, S.1    Eriksson, L.M.2    Thuresson, A.3    Larsson, M.4    Frison, L.5    Bylock, A.6
  • 21
    • 0001971729 scopus 로고    scopus 로고
    • Effect of acetylsalicylic acid on the pharmacodynamics and pharmacokinetics of melagatran, active form of the oral direct thrombin inhibitor H 376/95
    • Eriksson UG, Fager G, Eriksson LM, Cullberg M, Frison L, Bylock A, et al. Effect of acetylsalicylic acid on the pharmacodynamics and pharmacokinetics of melagatran, active form of the oral direct thrombin inhibitor H 376/95 (abstract). Clin Pharmacol Ther 2002;69(Suppl S):P24.
    • (2002) Clin Pharmacol Ther , vol.69 , Issue.SUPPL. S
    • Eriksson, U.G.1    Fager, G.2    Eriksson, L.M.3    Cullberg, M.4    Frison, L.5    Bylock, A.6
  • 22
    • 0035829034 scopus 로고    scopus 로고
    • Comparison of the oral direct thrombin inhibitor ximelagatran with enoxaparin as prophylaxis against venous thromboembolism after total knee replacement. A phase 2 dose-finding study
    • Heit JA, Colwell CW, Francis CW, Ginsberg JS, Berkowitz SD, Whipple J, et al. Comparison of the oral direct thrombin inhibitor ximelagatran with enoxaparin as prophylaxis against venous thromboembolism after total knee replacement. A phase 2 dose-finding study. Arch Intern Med 2001;161:2215-21.
    • (2001) Arch Intern Med , vol.161 , pp. 2215-2221
    • Heit, J.A.1    Colwell, C.W.2    Francis, C.W.3    Ginsberg, J.S.4    Berkowitz, S.D.5    Whipple, J.6
  • 23
    • 0036171348 scopus 로고    scopus 로고
    • A dose-ranging study of the oral direct thrombin inhibitor, ximelagatran, and its subcutaneous form, melagatran, compared to dalteparin in the prophylaxis of thromboembolism after hip or knee replacement: METHRO I
    • Eriksson BI, Arfwidsson AC, Frison L, Eriksson UG, Bylock A, Kalebo P, et al. A dose-ranging study of the oral direct thrombin inhibitor, ximelagatran, and its subcutaneous form, melagatran, compared to dalteparin in the prophylaxis of thromboembolism after hip or knee replacement: METHRO I. Thromb Haemost 2002;87(2):231-7.
    • (2002) Thromb Haemost , vol.87 , Issue.2 , pp. 231-237
    • Eriksson, B.I.1    Arfwidsson, A.C.2    Frison, L.3    Eriksson, U.G.4    Bylock, A.5    Kalebo, P.6
  • 24
    • 0001451271 scopus 로고    scopus 로고
    • METHRO II: Dose-response study of the novel oral, direct thrombin inhibitor, H 376/95 and its subcutaneous formulation melagatran, compared with dalteparin as thromboembolic prophylaxis after total hip or total knee replacement
    • Eriksson BI, Lindbratt S, Kalebo P, Bylock A, Frison L, Welin L, et al. METHRO II: dose-response study of the novel oral, direct thrombin inhibitor, H 376/95 and its subcutaneous formulation melagatran, compared with dalteparin as thromboembolic prophylaxis after total hip or total knee replacement (abstract). Haemostasis 2000;30(suppl 1):20-1.
    • (2000) Haemostasis , vol.30 , Issue.SUPPL. 1 , pp. 20-21
    • Eriksson, B.I.1    Lindbratt, S.2    Kalebo, P.3    Bylock, A.4    Frison, L.5    Welin, L.6
  • 25
    • 0037329702 scopus 로고    scopus 로고
    • Direct thrombin inhibitor melagatran followed by oral ximelagatran in comparison with enoxaparin for prevention of venous thromboembolism after total hip or knee replacement
    • Eriksson BI, Agnelli G, Cohen AT, Dahl OE, Mouret P, Rosencher N, et al. Direct thrombin inhibitor melagatran followed by oral ximelagatran in comparison with enoxaparin for prevention of venous thromboembolism after total hip or knee replacement. Thromb Haemost 2003;89:288-96.
    • (2003) Thromb Haemost , vol.89 , pp. 288-296
    • Eriksson, B.I.1    Agnelli, G.2    Cohen, A.T.3    Dahl, O.E.4    Mouret, P.5    Rosencher, N.6
  • 26
    • 0038001352 scopus 로고    scopus 로고
    • The oral direct thrombin inhibitor ximelagatran and its subcutaneous (sc) form melagatran, compared with enoxaparin for prophylaxis of venous thromboembolism (VTE) in total hip or total knee replacement (THR or TKR): The EXPRESS study
    • Philadelphia, December 6-10
    • Eriksson BI, Agnelli G, Cohen AT, Dahl OE, Lassen MR, Mouret P, et al. The oral direct thrombin inhibitor ximelagatran and its subcutaneous (sc) form melagatran, compared with enoxaparin for prophylaxis of venous thromboembolism (VTE) in total hip or total knee replacement (THR or TKR): The EXPRESS study (abstract). Presented at: American Society of Hematology 44th Annual Meeting. Philadelphia, December 6-10, 2002.
    • (2002) American Society of Hematology 44th Annual Meeting
    • Eriksson, B.I.1    Agnelli, G.2    Cohen, A.T.3    Dahl, O.E.4    Lassen, M.R.5    Mouret, P.6
  • 28
    • 0037663604 scopus 로고    scopus 로고
    • Randomized, double-blind, comparison of ximelagatran, an oral direct thrombin inhibitor, and warfarin to prevent venous thromboembolism (VTE) after total knee replacement (TKR)
    • Philadelphia, December 6-10
    • Francis CW, Berkowitz SD, Comp PC, Lieberman JR, Ginsberg JS, Paiement G, et al. Randomized, double-blind, comparison of ximelagatran, an oral direct thrombin inhibitor, and warfarin to prevent venous thromboembolism (VTE) after total knee replacement (TKR) (abstract). Presented at: American Society of Hematology 44th Annual Meeting. Philadelphia, December 6-10, 2002.
    • (2002) American Society of Hematology 44th Annual Meeting
    • Francis, C.W.1    Berkowitz, S.D.2    Comp, P.C.3    Lieberman, J.R.4    Ginsberg, J.S.5    Paiement, G.6
  • 30
    • 0038001344 scopus 로고    scopus 로고
    • Efficacy and tolerability of the oral direct thrombin inhibitor ximelagatran for the treatment of venous thromboembolism
    • Schulman S, Eriksson H, Lapidus L, Olsson C, Welin L, Frison L, et al. Efficacy and tolerability of the oral direct thrombin inhibitor ximelagatran for the treatment of venous thromboembolism (abstract). J Gen Intern Med 2002;17(suppl 1):131.
    • (2002) J Gen Intern Med , vol.17 , Issue.SUPPL. 1 , pp. 131
    • Schulman, S.1    Eriksson, H.2    Lapidus, L.3    Olsson, C.4    Welin, L.5    Frison, L.6
  • 31
    • 0037663608 scopus 로고    scopus 로고
    • Extended secondary prevention with the oral direct thrombin inhibitor ximelagatran for 18 months after 6 months of anticoagulation in patients with venous thromboembolism: A randomized, placebo-controlled trial
    • Philadelphia, December 6-10
    • Eriksson H, Wåhlander K, Lundström T, Clason SB, Schulman S. Extended secondary prevention with the oral direct thrombin inhibitor ximelagatran for 18 months after 6 months of anticoagulation in patients with venous thromboembolism: a randomized, placebo-controlled trial (abstract). Presented at: American Society of Hematology 44th Annual Meeting. Philadelphia, December 6-10, 2002.
    • (2002) American Society of Hematology 44th Annual Meeting
    • Eriksson, H.1    Wåhlander, K.2    Lundström, T.3    Clason, S.B.4    Schulman, S.5
  • 32
    • 0002210177 scopus 로고    scopus 로고
    • First experience with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation
    • Petersen P. First experience with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (abstract). J Gen Intern Med 2001;16(suppl 1):164.
    • (2001) J Gen Intern Med , vol.16 , Issue.SUPPL. 1 , pp. 164
    • Petersen, P.1
  • 34
    • 0347060679 scopus 로고    scopus 로고
    • A 2-year follow-up of ximelagatran as an oral anticoagulant for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation
    • Petersen P. A 2-year follow-up of ximelagatran as an oral anticoagulant for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation (abstract). Neurology 2002;58(suppl 3):a477.
    • (2002) Neurology , vol.58 , Issue.SUPPL. 3
    • Petersen, P.1
  • 35
    • 0038677824 scopus 로고    scopus 로고
    • SPORTIF III: A long-term randomized trial comparing ximelagatran with warfarin for prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation
    • Chicago, April 2
    • Halperin JL. SPORTIF III: a long-term randomized trial comparing ximelagatran with warfarin for prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation (abstract). Presented at: American College of Cardiology 52nd Annual Scientific Session, Chicago, April 2, 2003.
    • (2003) American College of Cardiology 52nd Annual Scientific Session
    • Halperin J.L. III1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.