Synthesis and crystal structures of substituted benzenes and benzoquinones as tissue factor VIIa inhibitors

Journal of Medicinal Chemistry

Volumn 46, Issue 20, 2003, Pages 4297-4312

  Parlow, John J ^a   Stevens, Anna M ^a   Stegeman, Roderick A ^a   Stallings, William C ^a   Kurumbail, Ravi G ^a   South, Michael S ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [3' AMINO 3 FLUORO 4 (ISOPROPYLAMINO) 1,1' BIPHENYL 2 YL] N [4 [AMINO(IMINO)METHYL]BENZYL]ACETAMIDE; BENZENE DERIVATIVE; BENZOQUINONE DERIVATIVE; BLOOD CLOTTING FACTOR 7A; BLOOD CLOTTING FACTOR 7A INHIBITOR; N [4 [AMINO(IMINO)METHYL]BENZYL] 2 [5 (ISOPROPYLAMINO) 3,6 DIOXO 2 PHENYLCYCLOHEXA 1,4 DIEN 1 YL]ACETAMIDE; UNCLASSIFIED DRUG;

AMINATION; ARTICLE; BLOOD CLOTTING; CRYSTAL STRUCTURE; DRUG INHIBITION; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

BENZENE DERIVATIVES; BENZOQUINONES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; FACTOR VIIA; FACTOR XA; HUMANS; MODELS, MOLECULAR; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN;

EID: 0141569437     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030233b     Document Type: Article

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