Design, Synthesis, and Crystal Structure of Selective 2-Pyridone Tissue Factor VIIa Inhibitors

Journal of Medicinal Chemistry

Volumn 46, Issue 22, 2003, Pages 4696-4701

  Parlow, John J ^a   Kurumbail, Ravi G ^a   Stegeman, Roderick A ^a   Stevens, Anna M ^a   Stallings, William C ^a   South, Michael S ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 PYRIDONE DERIVATIVE; 3 AMINO 5 [1 [2 [[4 [AMINO(IMINO)METHYL]BENZYL]AMINO] 2 OXOETHYL] 5 (ISOPROPYLAMINO) 6 OXO 1,6 DIHYDROPYRIDIN 2 YL]BENZOIC ACID; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7A; BLOOD CLOTTING FACTOR 7A INHIBITOR; BLOOD CLOTTING INHIBITOR; PYRIDINE DERIVATIVE; SERINE PROTEINASE; THROMBIN; UNCLASSIFIED DRUG;

ADDITION REACTION; ALKYLATION; ARTICLE; BIOTRANSFORMATION; BLOOD CLOTTING; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SELECTIVITY; DRUG SYNTHESIS; MOLECULAR INTERACTION; REACTION ANALYSIS; STEREOCHEMISTRY;

ACETAMIDES; BENZOIC ACIDS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; FACTOR VIIA; HUMANS; MODELS, MOLECULAR; PROTEASE INHIBITORS; PYRIDONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0142092475     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0301686     Document Type: Article

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