A non-sense mutation in Cd36 gene is associated with protection from severe malaria

Lancet

Volumn 357, Issue 9267, 2001, Pages 1502-1503

  Pain, Arnab ^a   Urban, Britta C ^a   Kai, Oscar ^b   Casals Pascual, Climent ^a   Shafi, Juma ^b   Marsh, Kevin ^b   Roberts, David J ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

Author keywords

[No Author keywords available]

Indexed keywords

AFRICA; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DNA POLYMORPHISM; ETHNIC GROUP; GENE MUTATION; HETEROZYGOSITY; HOST; HUMAN; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MALARIA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROGNOSIS; PROTECTION;

EID: 0035849284     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(00)04662-6     Document Type: Article

References (5)

1. Baruch DI, Ma XC, Pasloske B, Howard RJ, Miller LH. CD36 peptides that block cytoadherence define the CD36 binding region for Plasmodium falciparum-infected erythrocytes. Blood 1999; 94: 2121-27.
2. Kashiwagi H, Honda S, Tomiyama Y, et al. A novel polymorphism in glycoprotein IV (replacement of proline-90 by serine) predominates in subjects with platelet GPIV deficiency. Thromb Haemost 1993; 69: 481-84
3. Urban BU, Ferguson DJP, Pain A, Austyn J, Roberts DJ. Malaria infected erythrocytes modulate the maturation of dendritic cells. Nature 1999; 400: 73-77
4. Aitman TJ, Cooper LD, Norsworthy PJ, et al. Malaria susceptibility and CD36 mutation. Nature 2000; 405: 1015-16.
5. Miller LH. Impact of malaria on genetic polymorphism and genetic diseases in Africans and African Americans. Proc Natl Acad Sci USA 1994; 91: 2415-19.