Genetics: SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans

Science

Volumn 310, Issue 5755, 2005, Pages 1782-1786

  Lamason, Rebecca L ^a,l   Mohideen, Manzoor Ali P K ^a,m   Mest, Jason R ^a   Wong, Andrew C ^a,n   Norton, Heather L ^c   Aros, Michele C ^a   Jurynec, Michael J ^e   Mao, Xianyun ^c   Humphreville, Vanessa R ^a,b   Humbert, Jasper E ^b,f   Sinha, Soniya ^b   Moore, Jessica L ^a,o   Jagadeeswaran, Pudur ^g   Zhao, Wei ^b   Ning, Gang ^d   Makalowska, Izabela ^d   McKeigue, Paul M ^h   O'Donnell, David ^h   Kittles, Rick ⁱ   Parra, Esteban J ^j   Mangini, Nancy J ^k   Grunwald, David J ^e   Shriver, Mark D ^c   Canfield, Victor A ^b   Cheng, Keith C ^a,b   more..

^a PENN STATE CANCER INSTITUTE   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

^d PENNSYLVANIA STATE UNIVERSITY   (United States)

^e UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^f WEIS CENTER FOR RESEARCH   (United States)

^g UNIVERSITY OF NORTH TEXAS   (United States)

^h UNIVERSITY COLLEGE DUBLIN   (Ireland)

ⁱ OHIO STATE UNIVERSITY   (United States)

^j UNIVERSITY OF TORONTO   (Canada)

^k INDIANA UNIVERSITY SCHOOL OF MEDICINE NORTHWEST   (United States)

^l JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^m CASE WESTERN RESERVE UNIVERSITY   (United States)

ⁿ EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^o UNIVERSITY OF SOUTH FLORIDA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BIODIVERSITY; ION EXCHANGE; MICROORGANISMS; MUTAGENESIS; PIGMENTS;

CATION EXCHANGERS; MELANOSOMES; PIGMENTATION; ZEBRAFISH;

GENETIC ENGINEERING;

CATION TRANSPORT PROTEIN; PROTEIN SLC24A5; UNCLASSIFIED DRUG; ALANINE; ANTIPORTER; CALCIUM; MELANIN; SLC24A5 PROTEIN, HUMAN; SLC24A5 PROTEIN, ZEBRAFISH; THREONINE; ZEBRAFISH PROTEIN;

PIGMENT;

ALLELE; AMINO ACID SEQUENCE; ARTICLE; ASIAN; CATION EXCHANGE; CORRELATION ANALYSIS; EUROPE; GENE; GENE SEQUENCE; GENETIC CODE; GENETIC CONSERVATION; GENETIC POLYMORPHISM; GOLDEN GENE; HETEROZYGOSITY; HUMAN; LINKAGE ANALYSIS; MELANOSOME; MUTANT; NEGRO; NONHUMAN; NUCLEOTIDE SEQUENCE; ORTHOLOGY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SEQUENCE ANALYSIS; SKIN PIGMENTATION; ZEBRA FISH; AFRICAN AMERICAN; ANIMAL; CAUCASIAN; CHEMISTRY; EVOLUTION; GENE FREQUENCY; GENETIC SELECTION; GENETIC VARIABILITY; GENETICS; HAPLOTYPE; HETEROZYGOTE; ION TRANSPORT; METABOLISM; MOLECULAR GENETICS; MOUSE; MULTIFACTORIAL INHERITANCE; MUTATION; PHYSIOLOGY; PIGMENT EPITHELIUM; PRENATAL DEVELOPMENT; SINGLE NUCLEOTIDE POLYMORPHISM; ULTRASTRUCTURE;

DANIO RERIO;

AFRICAN AMERICANS; AFRICAN CONTINENTAL ANCESTRY GROUP; ALANINE; ALLELES; AMINO ACID SEQUENCE; ANIMALS; ANTIPORTERS; ASIAN CONTINENTAL ANCESTRY GROUP; CALCIUM; EUROPEAN CONTINENTAL ANCESTRY GROUP; EVOLUTION; GENE FREQUENCY; GENES; HAPLOTYPES; HETEROZYGOTE; HUMANS; ION TRANSPORT; MELANINS; MELANOSOMES; MICE; MOLECULAR SEQUENCE DATA; MULTIFACTORIAL INHERITANCE; MUTATION; PIGMENT EPITHELIUM OF EYE; POLYMORPHISM, SINGLE NUCLEOTIDE; SELECTION (GENETICS); SKIN PIGMENTATION; THREONINE; VARIATION (GENETICS); ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 29144485743     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1116238     Document Type: Article

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39. We thank P. Hubley for excellent management of our zebrafish facility; B. Blasiole, W. Boehmler, A. Sidor, and J. Gershenson for experimental assistance; R. Levenson, B. Kennedy, G. Chase, J. Carlson, and E. Puffenberger for helpful discussions; L. Rush for help on the cover design; and V. Hearing and M. Marks for MNT1 cells. Supported by funding from the Jake Gittlen Memorial Golf Tournament (K.C.), NSF (grant MCB9604923 to K.C.), NIH (grants CA73935, HD40179, and RR017441 to K.C.; HD37572 to D.G.; HG002154 to M.S.; EY11308 to N.M.; and HL077910 to P.J.), the Pennsylvania Tobacco Settlement Fund (K.C.), and the Natural Sciences and Engineering Research Council of Canada (E.P.). This work is dedicated to the open, trusting, and generous atmosphere fostered by the late George Streisinger.