-
1
-
-
13144306071
-
Genome-wide association studies for common diseases and complex traits
-
Hirschhorn JN, Daly MJ (2005) Genome-wide association studies for common diseases and complex traits. Nat Rev Genet 6: 95-108.
-
(2005)
Nat Rev Genet
, vol.6
, pp. 95-108
-
-
Hirschhorn, J.N.1
Daly, M.J.2
-
2
-
-
0033930144
-
Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28
-
Taillon-Miller P, Bauer-Sardina I, Saccone NL, Putzel J, Laitinen T, et al. (2000) Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28. Nat Genet 25: 324-328.
-
(2000)
Nat Genet
, vol.25
, pp. 324-328
-
-
Taillon-Miller, P.1
Bauer-Sardina, I.2
Saccone, N.L.3
Putzel, J.4
Laitinen, T.5
-
3
-
-
0035163547
-
Extent and distribution of linkage disequilibrium in three genomic regions
-
Abecasis GR, Noguchi E, Heinzmann A, Traherne JA, Bhattacharyya S, et al. (2001) Extent and distribution of linkage disequilibrium in three genomic regions. Am J Hum Genet 68: 191-197.
-
(2001)
Am J Hum Genet
, vol.68
, pp. 191-197
-
-
Abecasis, G.R.1
Noguchi, E.2
Heinzmann, A.3
Traherne, J.A.4
Bhattacharyya, S.5
-
4
-
-
0034791035
-
High-resolution haplotype structure in the human genome
-
Daly MJ, Rioux JD, Schaffner SF, Hudson TJ, Lander ES (2001) High-resolution haplotype structure in the human genome. Nat Genet 29: 229-232.
-
(2001)
Nat Genet
, vol.29
, pp. 229-232
-
-
Daly, M.J.1
Rioux, J.D.2
Schaffner, S.F.3
Hudson, T.J.4
Lander, E.S.5
-
5
-
-
0035941029
-
Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21
-
Patil N, Berno AJ, Hinds DA, Barrett WA, Doshi JM, et al. (2001) Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21. Science 294: 1719-1723.
-
(2001)
Science
, vol.294
, pp. 1719-1723
-
-
Patil, N.1
Berno, A.J.2
Hinds, D.A.3
Barrett, W.A.4
Doshi, J.M.5
-
6
-
-
0035837267
-
Linkage disequilibrium in the human genome
-
Reich DE, Cargill M, Bolk S, Ireland J, Sabeti PC, et al. (2001) Linkage disequilibrium in the human genome. Nature 411: 199-204.
-
(2001)
Nature
, vol.411
, pp. 199-204
-
-
Reich, D.E.1
Cargill, M.2
Bolk, S.3
Ireland, J.4
Sabeti, P.C.5
-
7
-
-
18444396271
-
A first-generation linkage disequilibrium map of human chromosome 22
-
Dawson E, Abecasis GR, Bumpstead S, Chen Y, Hunt S, et al. (2002) A first-generation linkage disequilibrium map of human chromosome 22. Nature 418: 544-548.
-
(2002)
Nature
, vol.418
, pp. 544-548
-
-
Dawson, E.1
Abecasis, G.R.2
Bumpstead, S.3
Chen, Y.4
Hunt, S.5
-
8
-
-
18444369013
-
The structure of haplotype blocks in the human genome
-
Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, et al. (2002) The structure of haplotype blocks in the human genome. Science 296: 2225-2229.
-
(2002)
Science
, vol.296
, pp. 2225-2229
-
-
Gabriel, S.B.1
Schaffner, S.F.2
Nguyen, H.3
Moore, J.M.4
Roy, J.5
-
9
-
-
0037370466
-
Chromosome-wide distribution of haplotype blocks and the role of recombination hot spots
-
Phillips MS, Lawrence R, Sachidanandam R, Morris AP, Balding DJ, et al. (2003) Chromosome-wide distribution of haplotype blocks and the role of recombination hot spots. Nat Genet 33: 382-387.
-
(2003)
Nat Genet
, vol.33
, pp. 382-387
-
-
Phillips, M.S.1
Lawrence, R.2
Sachidanandam, R.3
Morris, A.P.4
Balding, D.J.5
-
10
-
-
0034795550
-
Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex
-
Jeffreys AJ, Kauppi L, Neumann R (2001) Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex. Nat Genet 29: 217-222.
-
(2001)
Nat Genet
, vol.29
, pp. 217-222
-
-
Jeffreys, A.J.1
Kauppi, L.2
Neumann, R.3
-
11
-
-
3042700117
-
Evidence for substantial fine-scale variation in recombination rates across the human genome
-
Crawford DC, Bhangale T, Li N, Hellenthal G, Rieder MJ, et al. (2004) Evidence for substantial fine-scale variation in recombination rates across the human genome. Nat Genet 36: 700-706.
-
(2004)
Nat Genet
, vol.36
, pp. 700-706
-
-
Crawford, D.C.1
Bhangale, T.2
Li, N.3
Hellenthal, G.4
Rieder, M.J.5
-
12
-
-
2142773942
-
The fine-scale structure of recombination rate variation in the human genome
-
McVean GA, Myers SR, Hunt S, Deloukas P, Bentley DR, et al. (2004) The fine-scale structure of recombination rate variation in the human genome. Science 304: 581-584.
-
(2004)
Science
, vol.304
, pp. 581-584
-
-
McVean, G.A.1
Myers, S.R.2
Hunt, S.3
Deloukas, P.4
Bentley, D.R.5
-
13
-
-
13144265739
-
Genome-wide association studies: Theoretical and practical concerns
-
Wang WY, Barratt BJ, Clayton DG, Todd JA (2005) Genome-wide association studies: Theoretical and practical concerns. Nat Rev Genet 6: 109-118.
-
(2005)
Nat Rev Genet
, vol.6
, pp. 109-118
-
-
Wang, W.Y.1
Barratt, B.J.2
Clayton, D.G.3
Todd, J.A.4
-
14
-
-
79959503826
-
The International HapMap Project
-
The International HapMap Consortium (2003) The International HapMap Project. Nature 426: 789-796.
-
(2003)
Nature
, vol.426
, pp. 789-796
-
-
-
15
-
-
79959524146
-
A haplotype map of the human genome
-
In press
-
The International HapMap Consortium (2005) A haplotype map of the human genome. Nature. In press.
-
(2005)
Nature
-
-
-
16
-
-
13144282294
-
Exhaustive allelic transmission disequilibrium tests as a new approach to genome-wide association studies
-
Lin S, Chakravarti A, Cutler DJ (2004) Exhaustive allelic transmission disequilibrium tests as a new approach to genome-wide association studies. Nat Genet 36: 1181-1188.
-
(2004)
Nat Genet
, vol.36
, pp. 1181-1188
-
-
Lin, S.1
Chakravarti, A.2
Cutler, D.J.3
-
17
-
-
16844366786
-
Genome-wide strategies for detecting multiple loci that influence complex diseases
-
Marchini J, Donnelly P, Cardon LR (2005) Genome-wide strategies for detecting multiple loci that influence complex diseases. Nat Genet 37: 413-417.
-
(2005)
Nat Genet
, vol.37
, pp. 413-417
-
-
Marchini, J.1
Donnelly, P.2
Cardon, L.R.3
-
18
-
-
15944383403
-
Gene-environment interactions in human diseases
-
Hunter DJ (2005) Gene-environment interactions in human diseases. Nat Rev Genet 6: 287-298.
-
(2005)
Nat Rev Genet
, vol.6
, pp. 287-298
-
-
Hunter, D.J.1
-
19
-
-
0037461782
-
The mosaic that is our genome
-
Paabo S (2003) The mosaic that is our genome. Nature 421: 409-412.
-
(2003)
Nature
, vol.421
, pp. 409-412
-
-
Paabo, S.1
-
20
-
-
33646226097
-
Linkage disequilibrium in finite populations
-
Hill WG, Robertson A (1968) Linkage disequilibrium in finite populations. Theor Appl Genet 38: 226-231.
-
(1968)
Theor Appl Genet
, vol.38
, pp. 226-231
-
-
Hill, W.G.1
Robertson, A.2
-
21
-
-
0034977045
-
Linkage disequilibrium in humans: Models and data
-
Pritchard JK, Przeworski M (2001) Linkage disequilibrium in humans: Models and data. Am J Hum Genet 69: 1-14.
-
(2001)
Am J Hum Genet
, vol.69
, pp. 1-14
-
-
Pritchard, J.K.1
Przeworski, M.2
-
22
-
-
0023430504
-
Gametic disequilibrium measures: Proceed with caution
-
Hedrick PW (1987) Gametic disequilibrium measures: Proceed with caution. Genetics 117: 331-341.
-
(1987)
Genetics
, vol.117
, pp. 331-341
-
-
Hedrick, P.W.1
-
23
-
-
0034809334
-
Statistical tests of selective neutrality in the age of genomics
-
Nielsen R (2001) Statistical tests of selective neutrality in the age of genomics. Heredity 86: 641-647.
-
(2001)
Heredity
, vol.86
, pp. 641-647
-
-
Nielsen, R.1
-
24
-
-
0242524432
-
Patterns of human genetic diversity: Implications for human evolutionary history and disease
-
Tishkoff SA, Verrelli BC (2003) Patterns of human genetic diversity: Implications for human evolutionary history and disease. Annu Rev Genomics Hum Genet 4: 293-340.
-
(2003)
Annu Rev Genomics Hum Genet
, vol.4
, pp. 293-340
-
-
Tishkoff, S.A.1
Verrelli, B.C.2
-
25
-
-
0037167852
-
Detecting recent positive selection in the human genome from haplotype structure
-
Sabeti PC, Reich DE, Higgins JM, Levine HZ, Richter DJ, et al. (2002) Detecting recent positive selection in the human genome from haplotype structure. Nature 419: 832-837.
-
(2002)
Nature
, vol.419
, pp. 832-837
-
-
Sabeti, P.C.1
Reich, D.E.2
Higgins, J.M.3
Levine, H.Z.4
Richter, D.J.5
-
26
-
-
0035653671
-
Genetics of susceptibility to human infectious disease
-
Cooke GS, Hill AV (2001) Genetics of susceptibility to human infectious disease. Nat Rev Genet 2: 967-977.
-
(2001)
Nat Rev Genet
, vol.2
, pp. 967-977
-
-
Cooke, G.S.1
Hill, A.V.2
-
27
-
-
13944278863
-
A common inversion under selection in Europeans
-
Stefansson H, Helgason A, Thorleifsson G, Steinthorsdottir V, Masson G, et al. (2005) A common inversion under selection in Europeans. Nat Genet 37: 129-137.
-
(2005)
Nat Genet
, vol.37
, pp. 129-137
-
-
Stefansson, H.1
Helgason, A.2
Thorleifsson, G.3
Steinthorsdottir, V.4
Masson, G.5
-
28
-
-
0024313579
-
Statistical method for testing the neutral mutation hypothesis by DNA polymorphism
-
Tajima F (1989) Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. Genetics 123: 585-595.
-
(1989)
Genetics
, vol.123
, pp. 585-595
-
-
Tajima, F.1
-
29
-
-
0033911640
-
Hitchhiking under positive Darwinian selection
-
Fay JC, Wu CI (2000) Hitchhiking under positive Darwinian selection. Genetics 155: 1405-1413.
-
(2000)
Genetics
, vol.155
, pp. 1405-1413
-
-
Fay, J.C.1
Wu, C.I.2
-
30
-
-
0032884643
-
Recombination and the power of statistical tests of neutrality
-
Wall J (1999) Recombination and the power of statistical tests of neutrality. Genet Res 74: 65-79.
-
(1999)
Genet Res
, vol.74
, pp. 65-79
-
-
Wall, J.1
-
31
-
-
1542329549
-
Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans
-
Evans PD, Anderson JR, Vallender EJ, Gilbert SL, Malcom CM, et al. (2004) Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans. Hum Mol Genet 13: 489-494.
-
(2004)
Hum Mol Genet
, vol.13
, pp. 489-494
-
-
Evans, P.D.1
Anderson, J.R.2
Vallender, E.J.3
Gilbert, S.L.4
Malcom, C.M.5
-
32
-
-
19344374302
-
Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansion
-
DOI: 10.1371/journal.pbio.0020126
-
Kouprina N, Pavlicek A, Mochida GH, Solomon G, Gersch W, et al. (2004) Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansion. PLoS Biol 2: DOI: 10.1371/journal.pbio.0020126
-
(2004)
PLoS Biol
, vol.2
-
-
Kouprina, N.1
Pavlicek, A.2
Mochida, G.H.3
Solomon, G.4
Gersch, W.5
-
33
-
-
0347992009
-
Evolution of the human ASPM gene, a major determinant of brain size
-
Zhang J (2003) Evolution of the human ASPM gene, a major determinant of brain size. Genetics 165: 2063-2070.
-
(2003)
Genetics
, vol.165
, pp. 2063-2070
-
-
Zhang, J.1
-
34
-
-
0036157464
-
Complex signatures of natural selection at the Duffy blood group locus
-
Hamblin MT, Thompson EE, Di Rienzo A (2002) Complex signatures of natural selection at the Duffy blood group locus. Am J Hum Genet 70: 369-383.
-
(2002)
Am J Hum Genet
, vol.70
, pp. 369-383
-
-
Hamblin, M.T.1
Thompson, E.E.2
Di Rienzo, A.3
-
35
-
-
2442677652
-
Genetic signatures of strong recent positive selection at the lactase gene
-
Bersaglieri T, Sabeti PC, Patterson N, Vanderploeg T, Schaffner SF, et al. (2004) Genetic signatures of strong recent positive selection at the lactase gene. Am J Hum Genet 74: 1111-1120.
-
(2004)
Am J Hum Genet
, vol.74
, pp. 1111-1120
-
-
Bersaglieri, T.1
Sabeti, P.C.2
Patterson, N.3
Vanderploeg, T.4
Schaffner, S.F.5
-
36
-
-
0035978759
-
Natural selection and resistance to HIV
-
Schliekelman P, Garner C, Slatkin M (2001) Natural selection and resistance to HIV. Nature 411: 545-546.
-
(2001)
Nature
, vol.411
, pp. 545-546
-
-
Schliekelman, P.1
Garner, C.2
Slatkin, M.3
-
37
-
-
18444412585
-
A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity
-
Osier MV, Pakstis AJ, Soodyall H, Comas D, Goldman D, et al. (2002) A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. Am J Hum Genet 71: 84-99.
-
(2002)
Am J Hum Genet
, vol.71
, pp. 84-99
-
-
Osier, M.V.1
Pakstis, A.J.2
Soodyall, H.3
Comas, D.4
Goldman, D.5
-
38
-
-
0141455095
-
A method for detecting recent selection in the human genome from allele age estimates
-
Toomajian C, Ajioka RS, Jorde LB, Kushner JP, Kreitman M (2003) A method for detecting recent selection in the human genome from allele age estimates. Genetics 165: 287-297.
-
(2003)
Genetics
, vol.165
, pp. 287-297
-
-
Toomajian, C.1
Ajioka, R.S.2
Jorde, L.B.3
Kushner, J.P.4
Kreitman, M.5
-
39
-
-
0037158715
-
Molecular evolution of FOXP2, a gene involved in speech and language
-
Enard W, Przeworski M, Fisher SE, Lai CS, Wiebe V, et al. (2002) Molecular evolution of FOXP2, a gene involved in speech and language. Nature 418: 869-872.
-
(2002)
Nature
, vol.418
, pp. 869-872
-
-
Enard, W.1
Przeworski, M.2
Fisher, S.E.3
Lai, C.S.4
Wiebe, V.5
-
40
-
-
1842539589
-
Natural selection and molecular evolution in PTC, a bitter-taste receptor gene
-
Wooding S, Kim UK, Bamshad MJ, Larsen J, Jorde LB, et al. (2004) Natural selection and molecular evolution in PTC, a bitter-taste receptor gene. Am J Hum Genet 74: 637-646.
-
(2004)
Am J Hum Genet
, vol.74
, pp. 637-646
-
-
Wooding, S.1
Kim, U.K.2
Bamshad, M.J.3
Larsen, J.4
Jorde, L.B.5
-
41
-
-
0034976976
-
The use of intraallelic variability for testing neutrality and estimating population growth rate
-
Slatkin M, Bertorelle G (2001) The use of intraallelic variability for testing neutrality and estimating population growth rate. Genetics 158: 865-874.
-
(2001)
Genetics
, vol.158
, pp. 865-874
-
-
Slatkin, M.1
Bertorelle, G.2
-
42
-
-
2942737273
-
Molecular evolution of microcephalin, a gene determining human brain size
-
Wang YQ, Su B (2004) Molecular evolution of microcephalin, a gene determining human brain size. Hum Mol Genet 13: 1131-1137.
-
(2004)
Hum Mol Genet
, vol.13
, pp. 1131-1137
-
-
Wang, Y.Q.1
Su, B.2
-
43
-
-
2942744749
-
Reconstructing the evolutionary history of microcephalin, a gene controlling human brain size
-
Evans PD, Anderson JR, Vallender EJ, Choi SS, Lahn BT (2004) Reconstructing the evolutionary history of microcephalin, a gene controlling human brain size. Hum Mol Genet 13: 1139-1145.
-
(2004)
Hum Mol Genet
, vol.13
, pp. 1139-1145
-
-
Evans, P.D.1
Anderson, J.R.2
Vallender, E.J.3
Choi, S.S.4
Lahn, B.T.5
-
44
-
-
10344221021
-
Disentangling the effects of demography and selection in human history
-
Stajich JE, Hahn MW (2005) Disentangling the effects of demography and selection in human history. Mol Biol Evol 22: 63-73.
-
(2005)
Mol Biol Evol
, vol.22
, pp. 63-73
-
-
Stajich, J.E.1
Hahn, M.W.2
-
45
-
-
2342531738
-
The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus
-
Wang E, Ding YC, Flodman P, Kidd JR, Kidd KK, et al. (2004) The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus. Am J Hum Genet 74: 931-944.
-
(2004)
Am J Hum Genet
, vol.74
, pp. 931-944
-
-
Wang, E.1
Ding, Y.C.2
Flodman, P.3
Kidd, J.R.4
Kidd, K.K.5
-
46
-
-
4644367204
-
Positive selection on MMP3 regulation has shaped heart disease risk
-
Rockman MV, Hahn MW, Soranzo N, Loisel DA, Goldstein DB, et al. (2004) Positive selection on MMP3 regulation has shaped heart disease risk. Curr Biol 14: 1531-1539.
-
(2004)
Curr Biol
, vol.14
, pp. 1531-1539
-
-
Rockman, M.V.1
Hahn, M.W.2
Soranzo, N.3
Loisel, D.A.4
Goldstein, D.B.5
-
47
-
-
0344620583
-
Evidence for the multicentric origin of the sickle cell hemoglobin gene in Africa
-
Pagnier J, Mears JG, Dunda-Belkhodja O, Schaefer-Rego KE, Beldjord C, et al. (1984) Evidence for the multicentric origin of the sickle cell hemoglobin gene in Africa. Proc Natl Acad Sci U S A 81: 1771-1773.
-
(1984)
Proc Natl Acad Sci U S A
, vol.81
, pp. 1771-1773
-
-
Pagnier, J.1
Mears, J.G.2
Dunda-Belkhodja, O.3
Schaefer-Rego, K.E.4
Beldjord, C.5
-
48
-
-
12144289055
-
The evolution and population genetics of the ALDH2 locus: Random genetic drift, selection, and low levels of recombination
-
Oota H, Pakstis AJ, Bonne-Tamir B, Goldman D, Grigorenko E, et al. (2004) The evolution and population genetics of the ALDH2 locus: Random genetic drift, selection, and low levels of recombination. Ann Hum Genet 68: 93-109.
-
(2004)
Ann Hum Genet
, vol.68
, pp. 93-109
-
-
Oota, H.1
Pakstis, A.J.2
Bonne-Tamir, B.3
Goldman, D.4
Grigorenko, E.5
-
49
-
-
0033927855
-
Evidence for variable selective pressures at MC1R
-
Harding RM, Healy E, Ray AJ, Ellis NS, Flanagan N, et al. (2000) Evidence for variable selective pressures at MC1R. Am J Hum Genet 66: 1351-1361.
-
(2000)
Am J Hum Genet
, vol.66
, pp. 1351-1361
-
-
Harding, R.M.1
Healy, E.2
Ray, A.J.3
Ellis, N.S.4
Flanagan, N.5
-
50
-
-
0034425607
-
Adaptive evolution of the tumour suppressor BRCA1 in humans and chimpanzees. Australian Breast Cancer Family Study
-
Huttley GA, Easteal S, Southey MC, Tesoriero A, Giles GG, et al. (2000) Adaptive evolution of the tumour suppressor BRCA1 in humans and chimpanzees. Australian Breast Cancer Family Study. Nat Genet 25: 410-413.
-
(2000)
Nat Genet
, vol.25
, pp. 410-413
-
-
Huttley, G.A.1
Easteal, S.2
Southey, M.C.3
Tesoriero, A.4
Giles, G.G.5
|