메뉴 건너뛰기




Volumn 5, Issue 11, 2006, Pages 1184-1188

Lipid modification of secreted signaling proteins

Author keywords

Acyltransferase; Cholesterol; Epidermal growth factor receptor; Hedgehog; Lipid; Morphogen; Palmitoylation; Spitz; Wnt

Indexed keywords

ACYLTRANSFERASE; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR; LIGAND; LIPID; SONIC HEDGEHOG PROTEIN; WNT PROTEIN;

EID: 33744932941     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.5.11.2804     Document Type: Review
Times cited : (54)

References (51)
  • 1
    • 0036849497 scopus 로고    scopus 로고
    • Similarities between the Hedgehog and Wnt signaling pathways
    • Kalderon D. Similarities between the Hedgehog and Wnt signaling pathways. Trends Cell Biol 2002; 12:523-31.
    • (2002) Trends Cell Biol , vol.12 , pp. 523-531
    • Kalderon, D.1
  • 3
    • 0034161499 scopus 로고    scopus 로고
    • A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling
    • Hofmann K. A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling. Trends Biochem Sci 2000; 25:111-2.
    • (2000) Trends Biochem Sci , vol.25 , pp. 111-112
    • Hofmann, K.1
  • 4
    • 0035860538 scopus 로고    scopus 로고
    • Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the Hedgehog signal
    • Chamoun Z, Mann RK, Nellen D, von Kessler DP, Bellotto M, Beachy PA, Basler K. Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the Hedgehog signal. Science 2001; 293:2080-4.
    • (2001) Science , vol.293 , pp. 2080-2084
    • Chamoun, Z.1    Mann, R.K.2    Nellen, D.3    Von Kessler, D.P.4    Bellotto, M.5    Beachy, P.A.6    Basler, K.7
  • 5
    • 0035694931 scopus 로고    scopus 로고
    • Distinct roles of Central missing and Dispatched in sending the Hedgehog signal
    • Amanai K, Jiang J. Distinct roles of Central missing and Dispatched in sending the Hedgehog signal. Development 2001; 128:5119-27.
    • (2001) Development , vol.128 , pp. 5119-5127
    • Amanai, K.1    Jiang, J.2
  • 6
    • 0035942989 scopus 로고    scopus 로고
    • Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein
    • Lee JD, Treisman JE. Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein. Curr Biol 2001; 11:1147-52.
    • (2001) Curr Biol , vol.11 , pp. 1147-1152
    • Lee, J.D.1    Treisman, J.E.2
  • 7
    • 0036339605 scopus 로고    scopus 로고
    • Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling
    • Micchelli CA, The I, Selva E, Mogila V, Perrimon N. Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling. Development 2002; 129:843-51.
    • (2002) Development , vol.129 , pp. 843-851
    • Micchelli, C.A.1    The, I.2    Selva, E.3    Mogila, V.4    Perrimon, N.5
  • 9
    • 4043154959 scopus 로고    scopus 로고
    • Drosophila Wnt-1 undergoes a hydrophobic modification and is targeted to lipid rafts, a process that requires porcupine
    • Zhai L, Chaturvedi D, Cumberledge S. Drosophila Wnt-1 undergoes a hydrophobic modification and is targeted to lipid rafts, a process that requires porcupine. J Biol Chem 2004; 279:33220-7.
    • (2004) J Biol Chem , vol.279 , pp. 33220-33227
    • Zhai, L.1    Chaturvedi, D.2    Cumberledge, S.3
  • 10
    • 1842853184 scopus 로고    scopus 로고
    • Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates
    • Chen MH, Li YJ, Kawakami T, Xu SM, Chuang PT. Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev 2004; 18:641-59.
    • (2004) Genes Dev , vol.18 , pp. 641-659
    • Chen, M.H.1    Li, Y.J.2    Kawakami, T.3    Xu, S.M.4    Chuang, P.T.5
  • 11
    • 31744439979 scopus 로고    scopus 로고
    • Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion
    • Miura GI, Buglino J, Alvarado D, Lemmon MA, Resh MD, Treisman JE. Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion. Dev Cell 2006; 10:167-76.
    • (2006) Dev Cell , vol.10 , pp. 167-176
    • Miura, G.I.1    Buglino, J.2    Alvarado, D.3    Lemmon, M.A.4    Resh, M.D.5    Treisman, J.E.6
  • 13
    • 1242306884 scopus 로고    scopus 로고
    • Model organisms lead the way to protein palmitoyltransferases
    • Linder ME, Deschenes RJ. Model organisms lead the way to protein palmitoyltransferases. J Cell Sci 2004; 117:521-6.
    • (2004) J Cell Sci , vol.117 , pp. 521-526
    • Linder, M.E.1    Deschenes, R.J.2
  • 14
    • 0344464720 scopus 로고    scopus 로고
    • Wnts and Hedgehogs: Lipid-modified proteins and similarities in signaling mechanisms at the cell surface
    • Nusse R. Wnts and Hedgehogs: Lipid-modified proteins and similarities in signaling mechanisms at the cell surface. Development 2003; 130:5297-305.
    • (2003) Development , vol.130 , pp. 5297-5305
    • Nusse, R.1
  • 15
    • 0027368963 scopus 로고
    • Mutations in the segment polarity genes wingless and porcupine impair secretion of the Wingless protein
    • van den Heuvel M, Harryman-Samos C, Klingensmith J, Perrimon N, Nusse R. Mutations in the segment polarity genes wingless and porcupine impair secretion of the Wingless protein. EMBO J 1993; 12:5293-302.
    • (1993) EMBO J , vol.12 , pp. 5293-5302
    • Van Den Heuvel, M.1    Harryman-Samos, C.2    Klingensmith, J.3    Perrimon, N.4    Nusse, R.5
  • 16
    • 0030450052 scopus 로고    scopus 로고
    • The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing
    • Kadowaki T, Wilder E, Klingensmith J, Zachary K, Perrimon N. The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. Genes Dev 1996; 10:3116-28.
    • (1996) Genes Dev , vol.10 , pp. 3116-3128
    • Kadowaki, T.1    Wilder, E.2    Klingensmith, J.3    Zachary, K.4    Perrimon, N.5
  • 18
    • 0037066744 scopus 로고    scopus 로고
    • Drosophila segment polarity gene product Porcupine stimulates the posttranslational N-glycosylation of Wingless in the endoplasmic reticulum
    • Tanaka K, Kitagawa Y, Kadowaki T. Drosophila segment polarity gene product Porcupine stimulates the posttranslational N-glycosylation of Wingless in the endoplasmic reticulum. J Biol Chem 2002; 277:12816-23.
    • (2002) J Biol Chem , vol.277 , pp. 12816-12823
    • Tanaka, K.1    Kitagawa, Y.2    Kadowaki, T.3
  • 19
    • 0037429688 scopus 로고    scopus 로고
    • Signaling by the Drosophila epidermal growth factor receptor pathway during development
    • Shilo BZ. Signaling by the Drosophila epidermal growth factor receptor pathway during development. Exp Cell Res 2003; 284:140-9.
    • (2003) Exp Cell Res , vol.284 , pp. 140-149
    • Shilo, B.Z.1
  • 20
    • 0037213362 scopus 로고    scopus 로고
    • The on-off story of protein palmitoylation
    • Bijlmakers MJ, Marsh M. The on-off story of protein palmitoylation. Trends Cell Biol 2003; 13:32-42.
    • (2003) Trends Cell Biol , vol.13 , pp. 32-42
    • Bijlmakers, M.J.1    Marsh, M.2
  • 21
    • 33244463974 scopus 로고    scopus 로고
    • Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix
    • Callejo A, Torroja C, Quijada L, Guerrero I. Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix. Development 2006; 133:471-83.
    • (2006) Development , vol.133 , pp. 471-483
    • Callejo, A.1    Torroja, C.2    Quijada, L.3    Guerrero, I.4
  • 22
    • 33244482560 scopus 로고    scopus 로고
    • Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia
    • Gallet A, Ruel L, Staccini-Lavenant L, Therond PP. Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia. Development 2006; 133:407-18.
    • (2006) Development , vol.133 , pp. 407-418
    • Gallet, A.1    Ruel, L.2    Staccini-Lavenant, L.3    Therond, P.P.4
  • 23
    • 4544331178 scopus 로고    scopus 로고
    • Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein
    • Casali A, Struhl G. Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein. Nature 2004; 431:76-80.
    • (2004) Nature , vol.431 , pp. 76-80
    • Casali, A.1    Struhl, G.2
  • 25
    • 0035337027 scopus 로고    scopus 로고
    • An acylatable residue of Hedgehog is differentially required in Drosophila, and mouse limb development
    • Lee JD, Kraus P, Gaiano N, Nery S, Kohtz J, Fishell G, Loomis CA, Treisman JE. An acylatable residue of Hedgehog is differentially required in Drosophila, and mouse limb development. Dev Biol 2001; 233:122-36.
    • (2001) Dev Biol , vol.233 , pp. 122-136
    • Lee, J.D.1    Kraus, P.2    Gaiano, N.3    Nery, S.4    Kohtz, J.5    Fishell, G.6    Loomis, C.A.7    Treisman, J.E.8
  • 27
    • 0035368725 scopus 로고    scopus 로고
    • Cholesterol modification of Sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1
    • Lewis PM, Dunn MP, McMahon JA, Logan M, Martin JF, St-Jacques B, McMahon AP. Cholesterol modification of Sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell 2001; 105:599-612.
    • (2001) Cell , vol.105 , pp. 599-612
    • Lewis, P.M.1    Dunn, M.P.2    McMahon, J.A.3    Logan, M.4    Martin, J.F.5    St-Jacques, B.6    McMahon, A.P.7
  • 29
    • 33645228803 scopus 로고    scopus 로고
    • A highly conserved amino-terminal region of Sonic hedgehog is required for the formation of its freely diffusible multimeric form
    • Goetz JA, Singh S, Suber LM, Kull FJ, Robbins DJ. A highly conserved amino-terminal region of Sonic hedgehog is required for the formation of its freely diffusible multimeric form. J Biol Chem 2006; 281:4087-93.
    • (2006) J Biol Chem , vol.281 , pp. 4087-4093
    • Goetz, J.A.1    Singh, S.2    Suber, L.M.3    Kull, F.J.4    Robbins, D.J.5
  • 30
    • 18344378499 scopus 로고    scopus 로고
    • Lipoprotein particles are required for Hedgehog and Wingless signalling
    • Panakova D, Sprong H, Marois E, Thiele C, Eaton S. Lipoprotein particles are required for Hedgehog and Wingless signalling. Nature 2005; 435:58-65.
    • (2005) Nature , vol.435 , pp. 58-65
    • Panakova, D.1    Sprong, H.2    Marois, E.3    Thiele, C.4    Eaton, S.5
  • 31
    • 0037020216 scopus 로고    scopus 로고
    • Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of Dispatched
    • Ma Y, Erkner A, Gong R, Yao S, Taipale J, Basler K, Beachy PA. Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of Dispatched. Cell 2002; 111:63-75.
    • (2002) Cell , vol.111 , pp. 63-75
    • Ma, Y.1    Erkner, A.2    Gong, R.3    Yao, S.4    Taipale, J.5    Basler, K.6    Beachy, P.A.7
  • 32
    • 0033598964 scopus 로고    scopus 로고
    • Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified Hedgehog from signaling cells
    • Burke R, Nellen D, Bellotto M, Hafen E, Senti KA, Dickson BJ, Basler K. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified Hedgehog from signaling cells. Cell 1999; 99:803-15.
    • (1999) Cell , vol.99 , pp. 803-815
    • Burke, R.1    Nellen, D.2    Bellotto, M.3    Hafen, E.4    Senti, K.A.5    Dickson, B.J.6    Basler, K.7
  • 33
    • 12344310615 scopus 로고    scopus 로고
    • Functions of heparan sulfate proteoglycans in cell signaling during development
    • Lin X. Functions of heparan sulfate proteoglycans in cell signaling during development. Development 2004; 131:6009-21.
    • (2004) Development , vol.131 , pp. 6009-6021
    • Lin, X.1
  • 34
  • 35
    • 13244257603 scopus 로고    scopus 로고
    • The Drosophila, ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog
    • Gorfinkiel N, Sierra J, Callejo A, Ibanez C, Guerrero I. The Drosophila, ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog. Dev Cell 2005; 8:241-53.
    • (2005) Dev Cell , vol.8 , pp. 241-253
    • Gorfinkiel, N.1    Sierra, J.2    Callejo, A.3    Ibanez, C.4    Guerrero, I.5
  • 36
    • 0030584086 scopus 로고    scopus 로고
    • Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye
    • Freeman M. Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 1996; 87:651-60.
    • (1996) Cell , vol.87 , pp. 651-660
    • Freeman, M.1
  • 37
    • 5044249045 scopus 로고    scopus 로고
    • Small wing PLCgamma is required for ER retention of cleaved Spitz during eye development in Drosophila
    • Schlesinger A, Kiger A, Perrimon N, Shilo BZ. Small wing PLCgamma is required for ER retention of cleaved Spitz during eye development in Drosophila. Dev Cell 2004; 7:535-45.
    • (2004) Dev Cell , vol.7 , pp. 535-545
    • Schlesinger, A.1    Kiger, A.2    Perrimon, N.3    Shilo, B.Z.4
  • 38
    • 33645546778 scopus 로고    scopus 로고
    • Signal dynamics in Sonic hedgehog tissue patterning
    • Saha K, Schaffer DV. Signal dynamics in Sonic hedgehog tissue patterning. Development 2006; 133:889-900.
    • (2006) Development , vol.133 , pp. 889-900
    • Saha, K.1    Schaffer, D.V.2
  • 41
    • 3042799334 scopus 로고    scopus 로고
    • Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction
    • Torroja C, Gorfinkiel N, Guerrero I. Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction. Development 2004; 131:2395-408.
    • (2004) Development , vol.131 , pp. 2395-2408
    • Torroja, C.1    Gorfinkiel, N.2    Guerrero, I.3
  • 42
    • 0030297553 scopus 로고    scopus 로고
    • Dual roles for patched in sequestering and transducing Hedgehog
    • Chen Y, Struhl G. Dual roles for patched in sequestering and transducing Hedgehog. Cell 1996; 87:553-63.
    • (1996) Cell , vol.87 , pp. 553-563
    • Chen, Y.1    Struhl, G.2
  • 43
    • 0032577556 scopus 로고    scopus 로고
    • Wingless repression of Drosophila frizzled 2 expression shapes the Wingless morphogen gradient in the wing
    • Cadigan KM, Fish MP, Rulifson EJ, Nusse R. Wingless repression of Drosophila frizzled 2 expression shapes the Wingless morphogen gradient in the wing. Cell 1998; 93:767-77.
    • (1998) Cell , vol.93 , pp. 767-777
    • Cadigan, K.M.1    Fish, M.P.2    Rulifson, E.J.3    Nusse, R.4
  • 44
    • 30644480899 scopus 로고    scopus 로고
    • The endocytic pathway and formation of the Wingless morphogen gradient
    • Marois E, Mahmoud A, Eaton S. The endocytic pathway and formation of the Wingless morphogen gradient. Development 2006; 133:307-17.
    • (2006) Development , vol.133 , pp. 307-317
    • Marois, E.1    Mahmoud, A.2    Eaton, S.3
  • 46
    • 0029671192 scopus 로고    scopus 로고
    • Argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop
    • Golembo M, Schweitzer R, Freeman M, Shilo BZ. Argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop. Development 1996; 122:223-30.
    • (1996) Development , vol.122 , pp. 223-230
    • Golembo, M.1    Schweitzer, R.2    Freeman, M.3    Shilo, B.Z.4
  • 47
    • 4344611655 scopus 로고    scopus 로고
    • Argos inhibits epidermal growth factor receptor signalling by ligand sequestration
    • Klein DE, Nappi VM, Reeves GT, Shvartsman SY, Lemmon MA. Argos inhibits epidermal growth factor receptor signalling by ligand sequestration. Nature 2004; 430:1040-4.
    • (2004) Nature , vol.430 , pp. 1040-1044
    • Klein, D.E.1    Nappi, V.M.2    Reeves, G.T.3    Shvartsman, S.Y.4    Lemmon, M.A.5
  • 48
    • 0033580269 scopus 로고    scopus 로고
    • Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein
    • Chuang PT, McMahon AP. Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature 1999; 397:617-21.
    • (1999) Nature , vol.397 , pp. 617-621
    • Chuang, P.T.1    McMahon, A.P.2
  • 49
    • 0038783316 scopus 로고    scopus 로고
    • Secreted antagonists of the Wnt signalling pathway
    • Kawano Y, Kypta R. Secreted antagonists of the Wnt signalling pathway. J Cell Sci 2003; 116:2627-34.
    • (2003) J Cell Sci , vol.116 , pp. 2627-2634
    • Kawano, Y.1    Kypta, R.2
  • 50
    • 1842842204 scopus 로고    scopus 로고
    • pyramus and thisbe: FGF genes that pattern the mesoderm of Drosophila, embryos
    • Stathopoulos A, Tam B, Ronshaugen M, Frasch M, Levine M. pyramus and thisbe: FGF genes that pattern the mesoderm of Drosophila, embryos. Genes Dev 2004; 18:687-99.
    • (2004) Genes Dev , vol.18 , pp. 687-699
    • Stathopoulos, A.1    Tam, B.2    Ronshaugen, M.3    Frasch, M.4    Levine, M.5
  • 51
    • 0030582677 scopus 로고    scopus 로고
    • Branchless encodes a Drosophila, FGF homolog that controls tracheal cell migration and the pattern of branching
    • Sutherland D, Samakovlis C, Krasnow MA. branchless encodes a Drosophila, FGF homolog that controls tracheal cell migration and the pattern of branching. Cell 1996; 87:1091-101.
    • (1996) Cell , vol.87 , pp. 1091-1101
    • Sutherland, D.1    Samakovlis, C.2    Krasnow, M.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.