Argos inhibits epidermal growth factor receptor signalling by ligand sequestration

Nature

Volumn 430, Issue 7003, 2004, Pages 1040-1044

  Klein, Daryl E ^a   Nappi, Valerie M ^a   Reeves, Gregory T ^b   Shvartsman, Stanislav Y ^b   Lemmon, Mark A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Princeton University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODIVERSITY; GROWTH KINETICS; PROTEINS; TUMORS;

ARGOS FUNCTION; EPIDERMAL GROWTH FACTOR RECEPTOR (EDFR);

CELLS;

BONE MORPHOGENETIC PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; INHIBITOR PROTEIN; LIGAND; PROTEIN ARGOS; PROTEIN SPITZ; RECOMBINANT PROTEIN; SOMATOMEDIN BINDING PROTEIN; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG;

CANCER; MEDICINE;

ANIMAL CELL; ARTICLE; BINDING SITE; CANCER GROWTH; CELL SURFACE; COMPLEX FORMATION; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; IN VITRO STUDY; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN IMMOBILIZATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SURFACE PLASMON RESONANCE; ULTRACENTRIFUGATION;

ANIMALS; BINDING SITES; DOWN-REGULATION; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ELECTRON SPIN RESONANCE SPECTROSCOPY; EPIDERMAL GROWTH FACTOR; EYE PROTEINS; LIGANDS; MEMBRANE PROTEINS; NERVE TISSUE PROTEINS; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, INVERTEBRATE PEPTIDE; SIGNAL TRANSDUCTION;

ANIMALIA; DROSOPHILA MELANOGASTER; MELANOGASTER;

EID: 4344611655     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02840     Document Type: Article

References (27)

1. Jorissen, R. N. et al. Epidermal growth factor receptor: mechanisms of activation and signalling. Exp. Cell Res. 284, 31-53 (2003).
2. Yarden, Y. & Sliwkowski, M. X. Untangling the ErbB signalling network. Nature Rev. Mol. Cell Biol. 2, 127-137 (2001).
3. Shilo, B. Z. Signaling by the Drosophila epidermal growth factor receptor pathway during development. Exp. Cell Res. 284, 140-149 (2003).
4. Wiley, H. S., Shvartsman, S. Y. & Lauffenburger, D. A. Computational modeling of the EGF-receptor system: a paradigm for systems biology. Trends Cell Biol. 12, 43-50 (2003).
5. Schweitzer, R., Howes, R., Smith, R., Shilo, B. Z. & Freeman, M. Inhibition of Drosophila EGF receptor activation by the secreted protein Argos. Nature 376, 699-702 (1995).
6. Golembo, M., Schweitzer, R., Freeman, M. & Shilo, B. Z. Argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop. Development 122, 223-230 (1996).
7. Freeman, M., Klambt, C., Goodman, C. S. & Rubin, G. M. The argos gene encodes a diffusible factor that regulates cell fate decisions in the Drosophila eye. Cell 69, 963-975 (1992).
8. Wasserman, J. D. & Freeman, M. An autoregulatory cascade of EGF receptor signaling patterns the Drosophila egg. Cell 95, 355-364 (1998).
9. Jin, M. H., Sawamoto, K., Ito, M. & Okano, H. The interaction between the Drosophila secreted protein argos and the epidermal growth factor receptor inhibits dimerization of the receptor and binding of secreted spitz to the receptor. Mol. Cell. Biol. 20, 2098-2107 (2000).
10. Vinos, J. & Freeman, M. Evidence that Argos is an antagonistic ligand of the EGF receptor. Oncogene 19, 3560-3562 (2000).
11. Ferguson, K. M. et al. EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. Mol. Cell 11, 507-517 (2003).
12. Howes, R., Wasserman, J. D. & Freeman, M. In vivo analysis of Argos structure-function. Sequence requirements for inhibition of the Drosophila epidermal growth factor receptor. J. Biol. Chem. 273, 4275-4281 (1998).
13. Duan, C. Beyond carrier proteins: Specifying the cellular responses to IGF signals: roles of IGF-binding proteins. J. Endocrinol. 175, 41-54 (2002).
14. Groppe, I. et al. Structural basis of BMP signalling inhibition by the cystine knot protein Noggin. Nature 420, 636-642 (2002).
15. Mattoon, D., Klein, P., Lemmon, M. A., Lax, I. & Schlessinger, J. The tethered configuration of the EGF receptor extracellular domain exerts only a limited control of receptor function. Proc. Natl Acad. Sci. USA 101, 923-928 (2004).
16. Schlessinger, J., Shechter, Y., Willingham, M. C. & Pastan, I. Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells. Proc. Natl Acad. Sci. USA 75, 2659-2663 (1978).
17. Verveer, P. J., Wouters, F. S., Reynolds, A. R. & Bastiaens, P. I. Quantitative imaging of lateral ErbB1 receptor signal propagation in the plasma membrane. Science 290, 1567-1570 (2000).
18. Paine-Saunders, S., Viviano, B. L., Economides, A. N. & Saunders, S. Heparan sulfate proteoglycans retain Noggin at the cell surface: a potential mechanism for shaping bone morphogenetic protein gradients. J. Biol. Chem. 277, 2089-2096 (2002).
19. Powell, A. K., Yates, E. A., Fernig, D. G. & Turnbull, J. E. Interactions of heparin/heparan sulfate with proteins: appraisal of structural factors and experimental approaches. Glycobiology 14, 17R-30R (2004).
20. Kramer, K. L. & Yost, H. J. Heparan sulfate core proteins in cell-cell signaling. Annu. Rev. Genet. 37, 461-484 (2003).
21. Arend, W. P., Malyak, M., Guthridge, C. J. & Gabay, C. Interleukin-1 receptor antagonist: role in biology. Annu. Rev. Immunol. 16, 27-55 (1998).
22. Mantovani, A., Locati, M., Vecchi, A., Sozzani, S. & Allavena, P. Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines. Trends Immunol. 22, 328-336 (2001).
23. Barkai, N. & Shilo, B. Z. Modeling pattern formation: counting to two in the Drosophila egg. Curr. Biol. 12, R493-R495 (2002).
24. Shvartsman, S. Y., Muratov, C. B. & Lauffenburger, D. A. Modeling and computational analysis of EGF receptor-mediated cell communication in Drosophila oogenesis. Development 129, 2577-2589 (2002).
25. Salomon, D. S., Brandt, R., Ciardiello, F. & Normanno, N. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit. Rev. Oncol. Hematol. 19, 183-232 (1995).
26. Ferguson, K. M., Darling, P. J., Mohan, M. J., Macatee, T. L. & Lemmon, M. A. Extracellular domains drive homo- but not hetero-dimerization of erbB receptors. EMBO J. 19, 4632-4643 (2000).
27. Schweitzer, R., Shaharabany, M., Seger, R. & Shilo, B. Z. Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination. Genes Dev. 9, 1518-1529 (1995).