SEL1L a multifaceted protein playing a role in tumor progression

Journal of Cellular Physiology

Volumn 208, Issue 1, 2006, Pages 23-38

  Biunno, Ida ^a,c   Cattaneo, Monica ^a   Orlandi, Rosaria ^b   Canton, Cristina ^a   Biagiotti, Laura ^a   Ferrero, Stefano ^d   Barberis, Massimo ^e   Pupa, Serenella M ^b   Scarpa, Aldo ^f   Ménard, Sylvie ^b  

^a CNR   (Italy)

^b NATIONAL CANCER INSTITUTE   (Italy)

^c BioRep SrL   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

^e IRCCS MULTIMEDICA   (Italy)

^f UNIVERSITY OF VERONA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PROTEASOME; PROTEIN SEL1L; UBIQUITIN; UNCLASSIFIED DRUG;

CHROMOSOME 14Q; EXON; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; HUMAN; MOLECULAR CLONING; MOLECULAR EVOLUTION; NONHUMAN; NUCLEOTIDE SEQUENCE; ORTHOLOGY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; REVIEW; SEL1L GENE; STRUCTURE ANALYSIS; TUMOR GROWTH;

AMINO ACID SEQUENCE; ANIMALS; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 14; DISEASE PROGRESSION; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; EXONS; FETUS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MOLECULAR SEQUENCE DATA; NEOPLASM METASTASIS; NEOPLASMS; POLYMORPHISM, GENETIC; PROTEIN ISOFORMS; PROTEINS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

CAENORHABDITIS ELEGANS;

EID: 33744924211     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20574     Document Type: Review

References (97)

1. Aberle S, Schug N, Mathlouthi R, Seitz G, Kupper JH, Schroder K, Blin N. 2004. Promoter selection for the cytosine deaminase suicide gene constructs in gastric cancer. Eur J Gastroenterol Hepatol 16:63-67. Journal of Cellular Physiology DOI 10.1002/jcp
2. Allen JH, Nguyen LX, Sargent KE, Lipson KL, Hackett A, Urano F. 2004. High ER stress in beta-cells stimulates intracellular degradation of misfolded insulin. Biochem Biophys Res Commun 324:166-170.
3. Artavanis-Tsakonas S, Rand MD, Lake RJ. 1999. Notch signaling: Cell fate control and signal integration in development. Science 284:770-776. Review.
4. Bagatell R, Whitesell L. 2004. Altered Hsp90 function in cancer: A unique therapeutic opportunity. Mol Cancer Ther 3:1021-1030. Review.
5. Ban Y, Taniyama M, Tozaki T, Yanagawa T, Tomita M, Ban Y. 2001. SEL1L microsatellite polymorphism in Japanese patients with autoimmune thyroid diseases. Thyroid 11:335-338.
6. Barberis M, Roz E, Biunno I. 2005. SEL1L expression in prostatic intraepithelial neoplasia and adenocarcinomas: An immunohistochemical study. Histopathology (in press).
7. Bianchi L, Canton C, Bini L, Orlandi R, Menard S, Armini A, Cattaneo M. Pallini V, Bernardi LR, Biunno I. 2005. Protein profile changes in the human breast cancer cell line MCF-7 reponse to SEL1L gene induction. Proteomics 5:2433-2442.
8. Biunno I, Appierto V, Cattaneo M, Leone BE, Balzano G, Socci C, Saccone S, Letizia A, Della Valle G, Sgaramella V. 1997. Isolation of a pancreas-specific gene located on human chromosome 14q31: Expression analysis in human pancreatic ductal carcinomas. Genomics 46:284-286.
9. Biunno I, Bernard L, Dear P, Cattaneo M, Volorio S, Zannini L, Bankier A, Zollo M. 2000. SEL1L, the human homolog of C. elegans sel-1: Refined physical mapping, gene structure and identification of polymorphic markers. Hum Genet 106:227-235.
10. Biunno I, Castiglioni B, Rogozin IB, DeBellis G, Malferrari G, Cattaneo M. 2002. Cross-species conservation of SEL1L, a human pancreas-specific expressing gene. OMICS 6:187-198.
11. Blatch GL, Lassle M. 1999. The tetratricopeptide repeat: A structural motif mediating protein-protein interactions. Bioessays 21:932-939. Review.
12. Bruder E, Moch H. 2004. Pediatric renal cell carcinoma. Pathologe 25:324-327.
13. Capobianco AJ, Zagouras P, Blaumueller CM, Artavanis-Tsakonas S, Bishop JM. 1997. Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2. Mol Cell Biol 17:6265-6273.
14. Cattaneo M, Orlandi R, Ronchini C, Granelli P, Malferrari G, Menard S, Biunno I. 2000. The expression of SEL1L and TAN-1 in normal and neoplastic cells. Int J Biol Markers 15:26-32.
15. Cattaneo M, Zollo M, Malferrari G, Orlandi R, D'Angelo A, Menard S, Biunno I. 2001a. Allelic polymorphisms in the transcriptional regulatory region of human SEL1L. Mutat Res 458:71-76.
16. Cattaneo M, Sorio C, Malferrari G, Rogozin IB, Bernard L, Scarpa A, Zollo M, Biunno I. 2001b. Cloning and functional analysis of SEL1L promoter region, a pancreas-specific gene. DNA Cell Biol 20:1-9.
17. Cattaneo M, Orlandini S, Beghelli S, Moore PS, Sorio C, Bonora A, Bassi C, Talamini G, Zamboni G, Orlandi R, Menard S, Bernardi LR, Biunno I, Scarpa A. 2003. SEL1L expression in pancreatic adenocarcinoma parallels SMAD4 expression and delays tumor growth in vitro and in vivo. Oncogene 22:6359-6368.
18. Cattaneo M, Canton C, Albertini A, Biunno I. 2004. Identification of a region within SEL1L protein required for tumour growth inhibition. Gene 326:149-156.
19. Cattaneo M, Fontanella E, Canton C, Delia D, Biunno I. SEL1L affects human pancreatic cancer cell cycle and invasiveness through modulation of PTEN and genes related to cell-matrix interactions. Neoplasia (in press).
20. Chen YG, Lui HM, Lin SL, Lee JM, Ying SY. 2002. Regulation of cell proliferation, apoptosis, and carcinogenesis by activin. Exp Biol Med (Maywood) 227:75-87. Review.
21. Chiaramonte R, Calzavara E, Basile A, Comi P, Sherbet GV. 2002. Notch signal transduction is not regulated by SEL1L in leukaemia and lymphoma cells in culture. Anticancer Res 22:4211-4214.
22. Chin K, de Solorzano CO, Knowles D, Jones A, Chou W, Rodriguez EG, Kuo WL, Ljung BM, Chew K, Myambo K, Miranda M, Krig S, Garbe J, Stampfer M, Yaswen P, Gray JW, Lockett SJ. 2004. In situ analyses of genome instability in breast cancer. Nat Genet 36:984-988.
23. Ciocca DR, Calderwood SK. 2005. Heat shock proteins in cancer: Diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones 10:86-103.
24. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A. 2003. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: A bioinformatics assessment. Genome Res 13:2265-2270.
25. Cocolakis E, Lemay S, Ali S, Lebrun JJ. 2001. The p38 MAPK pathway is required for cell growth inhibition of human breast cancer cells in response to activin. J Biol Chem 276:18430-18446.
26. Conroy SE, Sasieni PD, Fentiman I, Latchman DS. 1998. Autoantibodies to the 90 kDa heat shock protein and poor survival in breast cancer patients. Eur J Cancer 34:942-943.
27. Das AK, Cohen PW, Barford D. 1998. The structure of the tetratricopeptide repeats of protein phosphatase 5: Implications for TPR-mediated protein-protein interactions. EMBO J 17:1192-1199.
28. Di Guglielmo GM, Le Roy C, Goodfellow AF, Wrana JL. 2003. Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. Nat Cell Biol 5:410-421.
29. Diaferia G, Cattaneo M, Saltini G, Proverbio MC, Monferini E, Malferrari G, Albertini A, Biunno I. 2004. RNA-mediated interference indicates that SEL1L plays a role in pancreatic beta-cell growth. DNA Cell Biol 23:510-518.
30. Dichamp C, Taillibert S, Aguirre-Cruz L, Lejeune J, Marie Y, Kujas M, Delattre JY, Hoang-Xuan K, Sanson M. 2004. Loss of 14q chromosome in oligodendroglial and astrocytic tumors. J Neurooncol 67:281-285.
31. Dissemond J, Busch M, Kothen T, Mors J, Weimann TK, Lindeke A, Goos M, Wagner SN. 2004. Differential downregulation of endoplasmic reticulum-residing chaperones calnexin and calreticulin in human metastatic melanoma. Cancer Lett 203:225-231.
32. Donoviel DB, Donoviel MS, Fan E, Hadjantonakis A, Bernstein A. 1998. Cloning and characterization of Sel-11, a murine homolog of the C. elegans sel-1 gene. Mech Dev 78:203-207.
33. Ellisen LW, Bird J, West DC, Soreng AL, Reynolds TC, Smith SD, Sklar J. 1991. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66:649-661.
34. Furue M, Zhang Y, Okamoto T, Hata RI, Asashima M. 2001. Activin A induces expression of rat Sel-11 mRNA, a negative regulator of notch signaling, in rat salivary gland-derived epithelial cells. Biochem Biophys Res Commun 282:745-749.
35. Gallahan D, Callahan R. 1997. The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4). Oncogene 14:1883-1890.
36. Granelli P, Cattaneo M, Ferrero S, Bottiglieri L, Bosari S, Fichera G, Biunno I. 2004. SEL1L and squamous cell carcinoma of the esophagus. Clinical Cancer Res 10:5857-5861.
37. Grant B, Greenwald I. 1996. The Caenorhabditis elegans sel-1 gene, a negative regulator of lin-12 and glp-1, encodes a predicted extracellular protein. Genetics 143:237-247.
38. Grant B, Greenwald I. 1997. Structure, function, and expression of SEL-1, a negative regulator of LIN-12 and GLP-1 in C. elegans. Development 124:637-644.
39. Greenwald I. 1998. LIN-12/Notch signaling: Lessons from worms and flies. Genes Dev 12:1751-1762. Review.
40. Hampton RY. 2002. ER-associated degradation in protein quality control and cellular regulation. Curr Opinion Cell Biol 14:476-482.
41. Hampton RY, Gardner RG, Rine J. 1996. Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol Biol Cell 7:2029-2044.
42. Harada Y, Ozaki K, Suzuki M, Fujiwara T, Takahashi E, Nakamura Y, Tanigami A. 1999. Complete cDNA sequence and genomic organization of a human pancreas-specific gene homologous to Caenorhabditis elegans sel-1. J Hum Genet 44:330-336.
43. Hart A, Papadopoulou S, Edlund H. 2003. Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells. Dev Dyn 228:185-193.
44. Hu J, Pang JC, Tong CY, Lau B, Yin XL, Poon WS, Jiang CC, Zhou LF, Ng HK. 2002. High-resolution genome-wide allelotype analysis identifies loss of chromosome 14q as a recurrent genetic alteration in astrocytic tumours. Br J Cancer 87:218-224.
45. Hu P, Han Z, Couvillon AD, Exton J. 2004. Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death. J Biol Chem 279:49420-49429.
46. Isfort RJ, Cody DB, Doersen CJ, Richards WG, Yoder BK, Wilkinson JE, Kier LD, Jirtle RL, Isenberg JS, Klounig JE, Woychik RP. 1997. The tetratricopeptide repeat containing Tg737 gene is a liver neoplasia tumor suppressor gene. Oncogene 15:1797-1803.
47. Iso T, Kedes L, Hamamori Y. 2003. HES and HERP families: Multiple effectors of the notch signaling pathway. J Cell Physiol 194:237-255.
48. Kamauchi S, Nakatani H, Nakano C, Urade R. 2005. Gene expression in response to endoplasmic reticulum stress in Arabidopsis thaliana. FASEB J 272:3461-3476.
49. Kaneko M, Nomura Y. 2003. ER signaling in unfolded protein response. Life Sci 74:199-205.
50. Kaufman RJ. 2002. Orchestrating the unfolded protein response in health and disease. J Clin Invest 110:1389-1398.
51. Kay BK, Williamson MP, Sudol M. 2000. The importance of being proline: The interaction of proline-rich motifs in signaling proteins with their cognate domains. FASEB J 14:231-241. Review.
52. Kikkert M, Doolman R, Dai M, Avner R, Hassink G, van Voorden S, Thanedar S, Roitelman J, Chau V, Wiertz E. 2004. Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum. J Biol Chem 279:3525-3534.
53. Kostova Z, Wolf DH. 2003. For whom the bell tolls: Protein quality control of the endoplasmic reticulum and the ubiquitin-proteasome connection. EMBO J 22:2309-2317. Review.
54. Kressel M, Schmucker B. 2002. Nucleocytoplasmic transfer of the NF2 tumor suppressor protein merlin is regulated by exon 2 and a CRM1-dependent nuclear export signal in exon 15. Hum Mol Genet 11:2269-2278.
55. Kus B, Gajadhar A, Stanger K, Cho R, Sun W, Rouleau N, Lee T, Chan D, Wolting C, Edwards A, Bosse R, Rotin D. 2005. A high throughput screen to identify substrates for the ubiquitin ligase Rsp5. J Biol Chem 280:29470-29478.
56. Larsen ZM, Angelo AD, Cattaneo M, Nerup J, Biunno I, Zollo M, Pociot F. 2001. Complete mutation scanning of the human SEL 1L gene: A candidate gene for type 1 diabetes. Acta Diabetol 38:191-192.
57. Lecca MR, Wagner U, Patrignani A, Berger EG, Hennet T. 2005. Genome-wide analysis of the unfolded protein response in fibroblasts from congenital disorders of glycosylation type-1 patients. FASEB J 19:240-242.
58. Lee DJ, Koch WM, Yoo G, Lango M, Reed A, Califano J, Brennan JA, Westra WH, Zahurak M, Sidransky D. 1997. Impact of chromosome 14q loss on survival in primary head and neck squamous cell carcinoma. Clin Cancer Res 3:501-505.
59. Lei J, Zou TT, Shi YQ, Zhou X, Smolinski KN, Yin J, Souza RF, Appel R, Wang S, Cymes K, Chan O, Abraham JM, Harpaz N, Meltzer SJ. 1996. Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms. Oncogene 13:2459-2462.
60. Lewinski MK, Bisgrove D, Shinn P, Chen H, Hoffmann C, Hannenhalli S, Verdin E, Berry CC, Ecker JR, Bushman FD. 2005. Genome-wide analysis of chromosomal features repressing human immunodeficiency virus transcription. J Virol 79:6610-6619.
61. Liu QY, Niranjan B, Gomes P, Gomm JJ, Davies D, Coombes RC, Buluwela L. 1996. Inhibitory effects of activin on the growth and morpholgenesis of primary and transformed mammary epithelial cells. Cancer Res 56:1155-1163.
62. Luthy L, Grutter MG, Mittl PR. 2004. The crystal structure of helicobacter cysteine-rich protein C at 2.0 A resolution: Similar peptide-binding sites in TPR and SEL1-like repeat proteins. J Mol Biol 340:829-841.
63. Mathlouthi R, Aberle S, Schug N, Kupper JH, Schroder K, Seitz G, Blin N. 2003. Assessing optimal promoter activity for constructs in gastrointestinal gene therapy. Anticancer Res 23:4011-4015.
64. Medeiros LJ, Palmedo G, Krigman HR, Kovacs G, Beckwith JB. 1999. Oncocytoid renal cell carcinoma after neuroblastoma: A report of four cases of a distinct clinicopathologic entity. Am J Surg Pathol 23:772-780.
65. Miele L, Osborne B. 1999. Arbiter of differentiation and death: Notch signaling meets apoptosis. J Cell Physiol 181:393-409. Review.
66. Nickoloff BJ, Osborne BA, Miele L. 2003. Notch signaling as a therapeutic target in cancer: A new approach to the development of cell fate modifying agents. Oncogene 22:6598-6608. Review.
67. Nobrega MA, Zhu Y, Plajzer-Frick I, Afzal V, Rubin EM. 2004. Megabase deletions of gene deserts result in viable mice. Nature 431:988-993.
68. Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ, Murray HL, Volkert TL, Schreiber J, Rolfe PA, Gifford DK, Fraenkel E, Bell GI, Young RA. 2004. Control of pancreas and liver gene expression by HNF transcription factors. Science 303:1378-1381.
69. Orlandi R, Cattaneo M, Troglio F, Casalini P, Ronchini C, Menard S, Biunno I. 2002a. SEL1L expression decreases breast tumor cell aggressiveness in vivo and in vitro. Cancer Res 62:567-574.
70. Orlandi R, Cattaneo M, Troglio F, Campiglio M, Biunno I, Menard S. 2002b. Production of a monoclonal antibody directed against the recombinant SEL1L protein. Int J Biol Markers 17:104-111.
71. Orlowski RZ, Dees EC. 2003. The role of the ubiquitination-proteasome pathway in breast cancer: Applying drugs that affect the ubiquitin-proteasome pathway to the therapy of breast cancer. Breast Cancer Res 5:1-7. Review.
72. Pear WS, Aster JC, Scott ML, Hasserjian RP, Soffer B, Sklar J, Baltimore D. 1996. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med 183:2283-2291.
73. Pece S, Serresi M, Santolini E, Capra M, Hulleman E, Galimberti V, Zurrida S, Maisonneuve P, Viale G, Di Fiore PP. 2004. Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol 167:215-221.
74. Petersen HH, Hilpert J, Militz D, Zandler V, Jacobsen C, Roebroek AJ, Willnow TE. 2003. Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule. J Cell Sci 116:453-461.
75. Pickford AR, Smith SP, Staunton D, Boyd J, Campbell ID. 2001. The hairpin structure of the (6)F1(1)F2(2)F2 fragment from human fibronectin enhances gelatin binding. EMBO J 20:1519-1529.
76. Pociot F, Larsen ZM, Zavattari P, Deidda E, Nerup J, Cattaneo M, Chiaramonte R, Comi P, Sabbadini M, Zollo M, Biunno I, Cucca F. 2001. No evidence for SEL1L as a candidate gene for IDDM11-conferred susceptibility. Diabetes Metab Res Rev 17:292-295.
77. Politi K, Feirt N, Kitajewski J. 2004. Notch in mammary gland development and breast cancer. Semin Cancer Biol 14:341-347. Review.
78. Polo S, Pece S, Di Fiore PP. 2004. Endocytosis and cancer. Curr Opin Cell Biol 16:156-161. Review.
79. Ponting CP. 2000. Proteins of the endoplasmic-reticulum-associated degradation pathway. Domain detection and function prediction. Biochem J 351:527-535.
80. Qu L, Koromilas AE. 2004. Control of tumor suppressor p53 function by endoplasmic reticulum stress. Cell Cycle 3:567-570.
81. Rajkumar SV, Richardson PG, Hideshima T, Anderson KC. 2005. Proteasome inhibition as a novel therapeutic target in human cancer. J Clin Oncol 23:630-639. Review.
82. Richards WG, Yoder BK, Isfort RJ, Detilleux PG, Foster C, Neilsen N, Woychik RP, Wilkinson JE. 1997. Isolation and characterization of liver epithelial cell lines from wild-type and mutant TgN737Rpw mice. Am J Pathol 150:1189-1197.
83. Richter K, Buchner J. 2001. Hsp90: Chaperoning signal transduction. J Cell Physiol 188:281-290.
84. Ron D. 2002. Translational control in the endoplasmic reticulum stress response. J Clin Invest 110:1383-1388. Review.
85. Rozenblum E, Schutte M, Goggins M, Hahn SA, Panzer S, Zahurak M, Goodman SN, Sohn TA, Hruban RH, Yeo CJ, Kern SE. 1997. Tumor-suppressive pathways in pancreatic carcinoma. Cancer Res 57:1731-1734.
86. Saltini G, Proverbio MC, Malferrari G, Biagiotti L, Boettcher P, Dominici R, Monferini E, Lorenzini E, Cattaneo M, Antonello D, Moore PS, Zamproni I, Viscardi M, Chiumello G, Biunno I. 2004. Identification of a novel polymorphism in the fibronectin type II domain of the SEL1L gene and possible relation to the persistent hyperinsulinemic hypoglycemia of infancy. Mutat Res 554:159-163.
87. Schutte M, Hruban RH, Hedrick L, Cho KR, Nadasdy GM, Weinstein CL, Bova GS, Isaacs WB, Cairns P, Nawroz H, Sidransky D, Casero RA, Jr., Meltzer PS, Hahn SA, Kern SE. 1996. DPC4 gene in various tumor types. Cancer Res 56:2527-2530.
88. Schwarte-Waldhoff I, Volpert OV, Bouck NP, Sipos B, Hahn SA, Klein-Scory S, Luttges J, Kloppel G, Graeven U, Eilert-Micus C, Hintelmann A, Schmiegel W. 2000. Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis. Proc Natl Acad Sci USA 97:9624-9629.
89. Stavridi ES, Halazonetis TD. 2004. p53 and stress in the ER. Genes Dev 18:241-244.
90. Stefani M. 2004. Protein misfolding and aggregation: New examples in medicine and biology of the dark side of the protein world. Biochim Biophys Acta 1739:5-25. Review.
91. Thorstensen L, Qvist H, Nesland JM, Giercksky KE, Lothe RA. 2001. Identification of two potential suppressor gene regions on chromosome arm 14q that are commonly lost in advanced colorectal carcinomas. Scand J Gastroenterol 36:1327-1331.
92. Tse JY, Ng HK, Lau KM, Lo KW, Poon WS, Huang DP. 1997. Loss of heterozygosity of chromosome 14q in low- and high-grade meningiomas. Hum Pathol 28:779-785.
93. Urano F, Calfon M, Yoneda T, Yun C, Kiraly M, Clark SG, Ron D. 2002. A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response. J Cell Biol 158:639-646.
94. Vargas-Roig LM, Gago FE, Tello O, Aznar JC, Ciocca DR. 1998. Heat shock protein expression and drug resistance in breast cancer patients treated with induction chemotherapy. Int J Cancer 79:468-475.
95. Wilson CA, Payton MN, Elliott GS, Buaas FW, Cajulis EE, Grosshans D, Ramos L, Reese DM, Slamon DJ, Calzone FJ. 1997. Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-delta11b. Oncogene 14:1-16.
96. Yoon K, Gaiano N. 2005. Notch signaling in the mammalian central nervous system: Insights from mouse mutants. Nat Neurosci 8:709-715. Review.
97. Zhang H, Li XJ, Martin DB, Aebersold R. 2003. Identification and quantification of N-Iinked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. Nat Biotechnol 21:660-666.