Promoter selection for the cytosine deaminase suicide gene constructs in gastric cancer

European Journal of Gastroenterology and Hepatology

Volumn 16, Issue 1, 2004, Pages 63-67

  Aberle, Susanne ^a   Schug, Nicola ^a   Mathlouthi, Rabea ^a   Seitz, Gerhard ^b   Küpper, Jan Heiner ^c   Schröder, Kristina ^c   Blin, Nikolaus ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b Hospital of Bamberg   (Germany)

^c Heart BioSystems GmbH   (Germany)

Author keywords

Cancer genes; Cytotoxicity; Gene therapy; Regulation; Stomach carcinoma

Indexed keywords

CARBOXYL ESTER LIPASE; CYTOKERATIN; CYTOSINE DEAMINASE; KRT19 PROTEIN; LUCIFERASE; MUCIN 1; MUCIN 4; PROTEIN; RECOMBINANT DNA; RECOMBINANT ENZYME; SEL1L PROTEIN; TELOMERASE REVERSE TRANSCRIPTASE; TFF1 PEPTIDE; TREFOIL PEPTIDE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ARTICLE; CANCER GENE THERAPY; CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; GENE ACTIVITY; GENE CONSTRUCT; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MONITORING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; STOMACH CARCINOMA; SUICIDE GENE; SUICIDE GENE THERAPY; TUMOR CELL; TUMOR CELL CULTURE; UPREGULATION; CELL DEATH; GENETICS; STOMACH TUMOR; SUICIDE TRANSGENE; TUMOR CELL LINE;

CELL DEATH; CELL LINE, TUMOR; CYTOSINE DEAMINASE; GENES, REPORTER; GENES, TRANSGENIC, SUICIDE; HUMANS; LUCIFERASES; PROMOTER REGIONS (GENETICS); STOMACH NEOPLASMS;

EID: 3042826251     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042737-200401000-00010     Document Type: Article

References (19)

1. Devesa SS, Blot WJ, Fraumeni JF Jr. Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer 1998; 83:2049-2053.
2. Tallarida RJ. The association of age and current world cancer mortality rates in relation to a century of cancer deaths in the U.S. Life Sci 1993; 53:459-464.
3. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988; 9:525-532.
4. Correa P, Chen VW. Gastric cancer. Cancer Surv 1994; 19-20:55-76.
5. Correa P. Gastric neoplasia. Curr Gastroenterol Rep 2002; 4:463-470.
6. Tamura G. Genetic and epigenetic alterations of tumor suppressor and tumor-related genes in gastric cancer. Histol Histopathol 2002; 17:323-329.
7. Jerome V, Muller R. Tissue-specific, cell cycle-regulated chimeric transcription factors for the targeting of gene expression to tumor cells. Hum Gene Ther 1998; 9:2653-2659.
8. Gurbuz Y, Kahlke V, Kloppel G. How do gastric carcinoma classification systems relate to mucin expression patterns? An immunohistochemical analysis in a series of advanced gastric carcinomas. Virchows Arch 2002; 440:505-511.
9. Andrianifahanana M, Moniaux N, Schmied BM, Ringel J, Friess H, Hollingsworth MA, et al. Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: a potential role of MUC4 as a tumor marker of diagnostic significance. Clin Cancer Res 2001; 7:4033-4040.
10. Cattaneo M, Sorio C, Malferrari G, Rogozin IB, Bernard L, Scarpa A, et al. Cloning and functional analysis of SEL1L promoter region, a pancreas-specific gene. DNA Cell Biol 2001; 20:1-9.
11. Welter C, Theisinger B, Rio MC, Seitz G, Schuder G, Blin N. Expression pattern of breast-cancer-associated protein pS2/BCEI in colorectal tumors. Int J Cancer 1994; 56:52-55.
12. Bartek J, Bartkova J, Schneider J, Taylor-Papadimitriou J, Kovarik J, Rejthar A. Expression of monoclonal antibody-defined epitopes of keratin 19 in human tumours and cultured cells. Eur J Cancer Clin Oncol 1986; 22:1441-1452.
13. Takakura M, Kyo S, Kanaya T, Hirano H, Takeda J, Yutsudo M, et al. Cloning of human telomerase catalytic subunit (HTERT) gene promoter and indentification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res 1999; 59:551-557.
14. Terada T, Kitamura Y, Ashida K, Matsunaga Y, Kato M, Harada K, et al. Expression of pancreatic digestive enzymes in normal and pathologic epithelial cells of the human gastrointestinal system. Virchows Arch 1997; 431:195-203.
15. Mullen CA, Kilstrup M, Blaese RM. Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system. Proc Natl Acad Sci USA 1992; 89:33-37.
16. Hsu EC, Hsi B, Hirota-Tsuchihara M, Ruland J, Iorio C, Sarangi F, et al. Modified apoptotic molecule (BID) reduces hepatitis C virus infection in mice with chimeric human livers. Nat Biotechnol 2003; 21:519-525.
17. Mullen CA. Metabolic suicide genes in gene therapy. Pharmacol Ther 1994; 63:199-207.
18. Block A, Chen SH, Kosai K, Finegold M, Woo SL. Adenoviral-mediated herpes simplex virus thymidine kinase gene transfer: regression of hepatic metastasis of pancreatic tumors. Pancreas 1997; 15:25-34.
19. Rosenfeld ME, Vickers SM, Raben D, Wang M, Sampson L, Feng M, et al. Pancreatic carcinoma cell killing via adenoviral mediated delivery of the herpes simplex virus thymidine kinase gene. Ann Surg 1997; 225:609-618.