Notch in mammary gland development and breast cancer

Seminars in Cancer Biology

Volumn 14, Issue 5, 2004, Pages 341-347

  Politi, Katerina ^a   Feirt, Nikki ^a   Kitajewski, Jan ^a  

^a 10032 ^*  (United States)

Author keywords

Breast cancer; Mammary gland; Notch; Signaling pathways

Indexed keywords

FIBROBLAST GROWTH FACTOR; NOTCH RECEPTOR;

ALLELE; BREAST CANCER; CARCINOGENESIS; CELL DIFFERENTIATION; EPITHELIUM CELL; GENE; HUMAN; IN VITRO STUDY; LIGAND BINDING; MAMMARY GLAND; MOUSE MAMMARY TUMOR ONCOVIRUS; NONHUMAN; PROTEIN EXPRESSION; REVIEW;

EID: 3342952083     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semcancer.2004.04.013     Document Type: Article

References (42)

1. Tekmal R.R., Keshava N. Role of MMTV integration locus cellular genes in breast cancer. Front Biosci. 2:1997;d519-d526
2. Daniel C.W., Smith G.H. The mammary gland: a model for development. J. Mammary Gland Biol. Neoplasia. 4:1999;3-8
3. Smith G.H., Boulanger C.A. Mammary epithelial stem cells: transplantation and self-renewal analysis. Cell Prolif. 36(Suppl. 1):2003;3-15
4. Artavanis-Tsakonas S., Matsuno K., Fortini M.E. Notch signaling. Science. 268:1995;225-232
5. Greenwald I. LIN-12/Notch signaling: lessons form worms and flies. Genes Dev. 12:1998;1751-1762
6. Wharton K.A., Johansen K.M., Xu T., Artavanis-Tsakonas S. Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell. 43:1985;567-581
7. Greenwald I. Structure/function studies of lin-12/Notch proteins. Curr. Opin. Genet. Dev. 4:1994;556-562
8. Blaumueller C.M., Qi H., Zagouras P., Artavanis-Tsakonas S. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell. 90:1997;281-291
9. Weinmaster G., Roberts V.J., Lemke G. A homolog of Drosphila Notch expressed during mammalian development. Development. 113:1991;199-205
10. Weinmaster G., Roberts V.J., Lemke G. Notch2: a second mammalian Notch gene. Development. 116:1992;931-941
11. Lardelli M., Dahlstrand J., Lendahl U. The novel Notch homologue mouse Notch3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium. Mech. Dev. 46:1994;123-136
12. Uyttendaele H., Marazzi G., Wu G., Yan Q., Sassoon D., Kitajewski J. Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development. 122:1996;2251-2259
13. Muskavitch M.A. Delta-notch signaling and Drosophila cell fate choice. Dev. Biol. 166:1994;415-430
14. Henderson S.T., Gao D., Christensen S., Kimble J. Functional domains of LAG-2, a putative signaling ligand for LIN-12 and GLP-1 receptors in Caenorhabditis elegans. Mol. Biol. Cell. 8:1997;1751-1762
15. De Strooper B., Annaert W., Cupers P., et al. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. 398:1999;518-522
16. Saxena M.T., Schroeter E.H., Mumm J.S., Kopan R. Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis. J. Biol. Chem. 276:2001;40268-40273
17. Struhl G., Greenwald I. Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature. 398:1999;522-525
18. Krantz I.D., Piccoli D.A., Spinner N.B. Clinical and molecular genetics of Alagille syndrome. Curr. Opin. Pediatr. 11:1999;558-564
19. Joutel A., Corpechot C., Ducros A., et al. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature. 383:1996;707-710
20. Gallahan D., Kozak C., Callahan R. A new common integration region (int-3) for mouse mammary tumor virus on mouse chromosome 17. J. Virol. 61:1987;218-220
21. Dievart A., Beaulieu N., Jolicoeur P. Involvement of Notch1 in the development of mouse mammary tumors. Oncogene. 18:1999;5973-5981
22. Nusse R., Varmus H.E. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell. 31:1982;99-109
23. Nusse R. The int genes in mammary tumorigenesis and in normal development. Trends Genet. 4:1988;291-295
24. Gallahan D., Callahan R. The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4). Oncogene. 14:1997;1883-1890
25. Smith G.H., Gallahan D., Diella F., Jhappan C., Merlino G., Callahan R. Constitutive expression of a truncated INT3 gene in mouse mammary epithelium impairs differentiation and functional development. Cell Growth Differ. 6:1995;563-577
26. Jhappan C., Gallahan D., Stahle C., et al. Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands. Genes Dev. 6:1992;345-355
27. Gallahan D., Jhappan C., Robinson G., et al. Expression of a truncated Int3 gene in developing secretory mammary epithelium specifically retards lobular differentiation resulting in tumorigenesis. Cancer Res. 56:1996;1775-1785
28. Soriano J.V., Uyttendaele H., Kitajewski J., Montesano R. Expression of an activated Notch4 (int-3) oncoprotein disrupts morphogenesis and induces an invasive phenotype in mammary epithelial cells in vitro. Int. J. Cancer. 86:2000;652-659
29. Uyttendaele H., Soriano J.V., Montesano R., Kitajewski J. Notch4 and Wnt-1 proteins function to regulate branching morphogenesis of mammary epithelial cells in an opposing fashion. Dev. Biol. 196:1998;204-217
30. Imatani A., Callahan R. Identification of a novel NOTCH-4/INT-3 RNA species encoding an activated gene product in certain human tumor cell lines. Oncogene. 19:2000;223-231
31. Callahan R. MMTV-induced mutations in mouse mammary tumors: their potential relevance to human breast cancer. Breast Cancer Res. Treatment. 39:1996;33-44
32. Robbins J., Blondel B.J., Gallahan D., Callahan R. Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells. J. Virol. 66:1992;2594-2599
33. Cardiff R.D., Munn R.J. Comparative pathology of mammary tumorigenesis in transgenic mice. Cancer Lett. 90:1995;13-19
34. Cardiff R.D., Sinn E., Muller W., Leder P. Transgenic oncogene mice. Tumor phenotype predicts genotype. Am. J. Pathol. 139:1991;495-501
35. Weijzen S., Rizzo P., Braid M., et al. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat. Med. 8:2002;979-986
36. Fitzgerald K., Harrington A., Leder P. Ras pathway signals are required for notch-mediated oncogenesis. Oncogene. 19:2000;4191-4198
37. Price J.V., Savenye E.D., Lum D., Breitkreutz A. Dominant enhancers of Egfr in Drosophila melanogaster: genetic links between the Notch and Egfr signaling pathways. Genetics. 147:1997;1139-1153
38. Zecchini V., Brennan K., Martinez-Arias A. An activity of Notch regulates JNK signalling and affects dorsal closure in Drosophila. Curr. Biol. 9:1999;460-469
39. Berset T., Hoier E.F., Battu G., Canevascini S., Hajnal A. Notch inhibition of RAS signaling through MAP kinase phosphate LIP-1 during C. elegans vulval development. Science. 291:2001;1055-1058
40. Carmena A., Buff E., Halfon M.S., et al. Reciprocal regulatory interactions between the Notch and Ras signaling pathways in the Drosophila embryonic mesoderm. Dev. Biol. 244:2002;226-242
41. Shaye D.D., Greenwald I. Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans. Nature. 420:2002;686-690
42. Siziopikou K., Jang M.-S., Miao H., Miele L. Notch signaling in ductal carcinoma in situ of the breast. Proc. Am. Assoc. Cancer Res. 43:2002;4