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Volumn 4, Issue 9, 2006, Pages 1768-1784

Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inhibitors of protein geranylgeranyltransferase-I

(8) Peng, Hairuo a Carrico, Dora a Thai, Van b Blaskovich, Michelle b Bucher, Cynthia b Pusateri, Erin E a Sebti, Said M b Hamilton, Andrew D a

a YALE UNIVERSITY (United States)

b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST SELECTIVITY; ENZYME INHIBITION; ESTERS; KETONES; SUBSTITUTION REACTIONS; SUBSTRATES; SYNTHESIS (CHEMICAL);

FREE CARBOXYL TERMINUS; PHARMACOPHORES; PIPERAZIN-2-ONE;

ENZYMES;

ENZYME INHIBITOR; GERANYLGERANYLTRANSFERASE TYPE I; GERANYLGERANYLTRANSFERASE TYPE-I; KETONE; PIPERAZINE DERIVATIVE; TRANSFERASE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; DRUG ANTAGONISM; HUMAN; MOLECULAR MIMICRY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ALKYL AND ARYL TRANSFERASES; AMINO ACID SEQUENCE; ANIMALS; ENZYME INHIBITORS; HUMANS; KETONES; MOLECULAR MIMICRY; PIPERAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33744806644 PISSN: 14770520 EISSN: None Source Type: Journal
DOI: 10.1039/b517572k Document Type: Article

Times cited : (49)

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