Anions Modulate the Potency of Geranylgeranyl-Protein Transferase I Inhibitors

Journal of Biological Chemistry

Volumn 276, Issue 27, 2001, Pages 24457-24465

  Huber, Hans E ^a   Robinson, Ronald G ^a   Watkins, Aubrey ^a   Nahas, Deborah D ^a   Abrams, Marc T ^a   Buser, Carolyn A ^a   Lobell, Robert B ^a   Patrick, Denis ^a,b   Anthony, Neville J ^a   Dinsmore, Christopher J ^a   Graham, Samuel L ^a   Hartman, George D ^a   Lumma, William C ^a   Williams, Theresa M ^a   Heimbrook, David C ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; ENZYME INHIBITION; NEGATIVE IONS; PHOSPHATES; PROTEINS;

INHIBITORS;

BIOCHEMISTRY;

ADENOSINE TRIPHOSPHATE; ANION; FARNESYL TRANS TRANSFERASE; GERANYLGERANYL PROTEIN TRANSFERASE I INHIBITOR; GERANYLGERANYL PROTEIN TRANSFERASE I PROTEIN; GERANYLGERANYL PYROPHOSPHATE; GERANYLTRANSFERASE; L 778123; PEPTIDE; PHOSPHATE; PROTEIN; PROTEIN FARNESYLTRANSFERASE; RAP1A PROTEIN; UNCLASSIFIED DRUG; ENZYME INHIBITOR; GERANYLGERANYLTRANSFERASE TYPE I; GERANYLGERANYLTRANSFERASE TYPE-I; IMIDAZOLE DERIVATIVE; ISOPRENOID PHOSPHATE; L 778,123; P21(RAS) FARNESYL PROTEIN TRANSFERASE; P21(RAS) FARNESYL-PROTEIN TRANSFERASE; TRANSFERASE;

ARTICLE; COMPETITIVE INHIBITION; DRUG POTENCY; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME STRUCTURE; ENZYME SUBSTRATE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; PROTEIN PROCESSING; STRUCTURE ACTIVITY RELATION; BINDING COMPETITION; CHEMICAL MODEL; DRUG ANTAGONISM; HUMAN; KINETICS; METABOLISM; PROTEIN BINDING;

ADENOSINE TRIPHOSPHATE; ALKYL AND ARYL TRANSFERASES; ANIONS; BINDING, COMPETITIVE; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; KINETICS; MODELS, CHEMICAL; POLYISOPRENYL PHOSPHATES; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035816644     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M100325200     Document Type: Article

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