Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 11, 2001, Pages 1411-1415

  Bergman, Jeffrey M ^a   Abrams, Marc T ^a   Davide, Joseph P ^a   Greenberg, Ian B ^a   Robinson, Ronald G ^a   Buser, Carolyn A ^a   Huber, Hans E ^a   Koblan, Kenneth S ^a   Kohl, Nancy E ^a   Lobell, Robert B ^a   Graham, Samuel L ^a   Hartman, George D ^a   Williams, Theresa M ^a   Dinsmore, Christopher J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GERANYLTRANSFERASE; PIPERAZINE DERIVATIVE; PIPERAZINONE DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

ALKYL AND ARYL TRANSFERASES; DRUG DESIGN; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; GENES, RAS; PIPERAZINES; POLYMERS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035806168     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00240-2     Document Type: Article

References (21)