Geranylgeranyl diphosphate-based inhibitors of post-translational geranylgeranylation of cellular proteins

Journal of Medicinal Chemistry

Volumn 39, Issue 7, 1996, Pages 1352-1356

  Macchia, Marco ^a   Jannitti, Nicoletta ^a   Gervasi, Gianbattista ^b   Danesi, Romano ^c  

^a UNIVERSITY OF PISA   (Italy)

^b Laboratori Baldacci   (Italy)

^c SCUOLA SUPERIORE SANT ANNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

[2 OXO 2 [[(3,7,11,15 TETRAMETHYL 2,6,10,14 HEXADECATETRAENYL)OXY]AMINO]ETHYL]PHOSPHONIC ACID; ENZYME INHIBITOR; GERANYLGERANYL PROTEIN TRANSFERASE INHIBITOR; N AMINOSULFONYL O (3,7,11,15 TETRAMETHYL 2,6,10,14 HEXADECATETRAENYL)URETHANE; PHOSPHONIC ACID DERIVATIVE; PHOSPHONOACETIC ACID; PROTEIN FARNESYLTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ESTERIFICATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MALE; ONCOGENE RAS; PROSTATE CANCER; PROTEIN PROCESSING;

ALKYL AND ARYL TRANSFERASES; ANTINEOPLASTIC AGENTS; CELL DIVISION; ENZYME INHIBITORS; GTP-BINDING PROTEINS; HUMANS; IMMUNOBLOTTING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MOLECULAR STRUCTURE; POLYISOPRENYL PHOSPHATES; PROSTATIC NEOPLASMS; PROTEIN ISOPRENYLATION; PROTO-ONCOGENE PROTEINS P21(RAS); RAP GTP-BINDING PROTEINS; TRANSFERASES; TUMOR CELLS, CULTURED;

EID: 0029938011     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960127s     Document Type: Article

References (10)

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