Hyperhomocysteinemia increases damage on brain slices exposed to in vitro model of oxygen and glucose deprivation: prevention by folic acid

International Journal of Developmental Neuroscience

Volumn 24, Issue 4, 2006, Pages 285-291

  Tagliari, Bárbara ^a   Zamin, Lauren L ^a   Salbego, Christianne G ^a   Netto, Carlos Alexandre ^a   Wyse, Angela T S ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Cerebral ischemia; Folic acid; Homocysteine; Inborn errors of metabolism; Rat; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; FOLIC ACID; GLUCOSE; HOMOCYSTEINE; OXYGEN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CELL DAMAGE; CONTROLLED STUDY; HYPERHOMOCYSTEINEMIA; HYPOXIA; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REOXYGENATION;

ANALYSIS OF VARIANCE; ANIMALS; ANOXIA; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; DRUG INTERACTIONS; FOLIC ACID; GLUCOSE; HOMOCYSTEINE; HYPERHOMOCYSTEINEMIA; HYPOXIA-ISCHEMIA, BRAIN; LACTATE DEHYDROGENASES; MALE; RATS; RATS, WISTAR; VITAMIN A; VITAMIN B COMPLEX;

RATTUS NORVEGICUS;

EID: 33646836104     PISSN: 07365748     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijdevneu.2006.01.002     Document Type: Article

References (66)

1. Almli L.M., Hamrick S.E., Koshy A.A., Tauber M.G., and Ferriero D.M. Multiple pathways of neuroprotection against oxidative stress and excitotoxic injury in immature primary hippocampal neurons. Dev. Brain Res. 132 (2001) 121-129
2. Assanelli D., Bonamone A., Pezzini A., Albertini F., Maccali P., Grassi M., Archetti S., Negrini R., and Visioli F. Folic acid and Vitamin E supplementation effects on homocysteinemia, endothelial function and plasma antioxidant capacity in young myocardial-infarction patients. Pharmacol. Res. 49 (2004) 79-84
3. Botez M.I., Young S.N., Bachevalier J., and Gauthier S. Effect of folic acid and Vitamin B12 deficiencies on 5-hydroxyindoleacetic acid in human cerebrospinal fluid. Ann. Neurol. 12 (1982) 479-484
4. Bottiglieri T. Homocysteine and folate metabolism in depression. Prog. Neuropsychopharmacol. Biol. Psychiatr. 29 (2005) 1103-1112
5. Cárdenas A., Moro M.A., Hurtado O., Leza J.C., Lorenzo P., Castrillo A., Bodelo'n O.G., Bosca' O.G., and Lizasoain I. Implication of glutamate in the expression of inducible nitric oxide synthase after oxygen and glucose deprivation in rat forebrain slices. J. Neurochem. 74 (2000) 2041-2048
6. Chaudhary G., Sinha K., and Gupta Y.K. Protective effect of exogenous administration of a-tocopherol in middle cerebral artery occlusion model of cerebral ischemia in rats. Fund. Clin. Pharmacol. 17 (2003) 703-707
7. Cimarosti H., Rodnight R., Tavares A., Paiva R., Valentim L., Rocha E., and Salbego C. An investigation of the neuroprotective effect of lithium in organotypic slice cultures of rat hippocampus exposed to oxygen and glucose deprivation. Neurosci. Lett. 315 (2001) 33-36
8. Clarke R., Smith A.D., Jobst K.A., Refsum H., Sutton L., and Ueland P.M. Folate, Vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch. Neurol. 55 (1998) 1449-1455
9. Daly L.E., Kirke P.N., Molloy A., Weir D.G., and Scott J.M. Folate levels and neural tube defects. Implications for prevention. JAMA 274 (1995) 1698-1702
10. Delwing D., Chiarani F., Bavaresco C.S., Wannmacher C.M.D., Wajner M., Dutra-Filho C.S., and Wyse A.T.S. Protective effect of antioxidants on brain oxidative damage caused by proline administration. Neurosci. Res. 52 (2005) 69-74
11. Dwyer B.E., Raina A.K., Perry G., and Smith M.A. Homocysteine and Alzheime's disease: a modifiable risk?. Free Radic. Biol. Med. 36 (2004) 1471-1475
12. Eikelboom J.W., Hankey G.J., Anand S.S., Lofthouse E., Staples N., and Baker R.I. Association between high homocyst(e)ine and ischemic stroke due to large- and small-artery disease but not other etiologic subtypes of ischemic stroke. Stroke 31 (2000) 1069-1075
13. El Kossi M.M.H., and Zakhary M.M. Oxidative stress in the context of acute cerebrovascular stroke. Stroke 31 (2000) 1889-1892
14. Faraci F.M., and Lentz S.R. Hyperhomocysteinemia, oxidative stress, and cerebral vascular dysfunction. Stroke 35 (2004) 345-347
15. +-ATPase activity in synaptic plasma membrane of rat hippocampus. Int. J. Dev. Neurosci. 21 (2003) 303-307
16. Fujimoto S., Katsuki H., Kume T., Kaneko S., and Akaike A. Mechanisms of oxygen glucose deprivation-induced glutamate release from cerebrocortical slice cultures. Neurosci. Res. 50 (2004) 179-187
17. Gilgun-Sherki Y., Rosenbaum Z., Melamed E., and Offen D. Antioxidant therapy in acute central nervous system injury: current state. Pharmacol. Rev. 54 (2002) 271-284
18. Halliwell B., and Gutteridge J.M. Free Radicals in Biology and Medicine (1999), Oxford University Press, New York
19. Hankey G.J., and Eikelboom V.W. Homocysteine and stroke. Curr. Opin. Neurol. 14 (2001) 95-102
20. Hassan A., Hunt B.J., O'Sullivan M., Bell R., D'Souza R., Jeffery S., Bamford J.M., and Markus H.S. Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction. Brain 127 (2004) 212-219
21. He K., Marchant A., Rimm E.B., Rosner B.A., Stampfer M.J., Willter W.C., and Ascherio A. Folate, Vitamin B6, and B12 intakes in relation of risk of stroke among men. Stroke 35 (2004) 169-174
22. Ho P.I., Ortiz D., Rogers E., and Shea T.B. Multiple aspects of homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactivation and DNA damage. J. Neurosci. Res. 70 (2002) 694-702
23. Homocysteine Lowering Trialists' Collaboration. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. BMJ 316 (1998) 894-898
24. Koh J.Y., and Choi D.W. Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay. J. Neurosci. Meth. 20 (1987) 83-90
25. Korczyn A.D. Homocysteine, stroke, and dementia. Stroke 33 (2002) 2343-2344
26. Kruman I.I., Kumaravel T.S., Lohani A., Pedersen W.A., Culter R.G., Kruman Y., Haughey N., Lee J., Evans M., and Mattson M.P. Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. J. Neurosci. 22 (2002) 1752-1762
27. Lalonde R., Joyal C.C., and Botez M.I. Effects of folic acid and folinic acid on cognitive and motor behaviors in 20-month-old rats. Pharmacol. Biochem. Behav. 44 (1993) 703-707
28. Lamers Y., Prinz-Langenohl R., Moser R., and Pietrzik K. Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces plasma total homocysteine concentrations in healthy women. Am. J. Clin. Nutr. 79 (2004) 473-478
29. Lipton P. Ischemic cell death in brain neurons. Physiol. Rev. 79 (1999) 1-33
30. Loscalzo J. Homocysteine and dementias. N. Engl. J. Med. 346 (2002) 466-468
31. +-ATPase activity in parietal, prefrontal and cingulate cortex of young rats. Int. J. Dev. Neurosci. 22 (2004) 185-190
32. Mattson M.P., Kruman I.I., and Duan W. Folic acid and homocysteine in age-related disease. Ageing Res. Rev. 1 (2002) 95-111
33. Mattson M.P., and Shea T.B. Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci. 26 (2003) 137-146
34. McCaddon A., Regland B., Hudson P., and Davies G. Functional Vitamin B12 deficiency and Alzheimer disease. Neurology 58 (2002) 1395-1399
35. Moore J.L. The significance of folic acid for epilepsy patients. Epilepsy Behav. 7 (2005) 172-181
36. Morris M.S. Homocysteine and Alzheimer's disease. Lancet Neurol. 2 (2003) 425-428
37. Mudd S.H., Levy H.L., and Skovby F. Disorders of transulfuration. In: Scriver C.R., Beaudet A.L., Sly W.S., and Valle D. (Eds). The Metabolic and Molecular Bases of Inherited Disease vol. 2 (2001), McGraw-Hill, New York 1279-1327
38. Pfanzagl B. Ascorbate is particularly effective against LDL oxidation in the presence of iron(III) and homocysteine/cystine at acidic pH. Biochim. Biophys. Acta 1736 (2005) 237-243
39. Racek J., Rusňáková H., Trefil L., and Siala K.K. The influence of folate and antioxidants on homocysteine levels and oxidative stress in patients with hyperlipidemia and hyperhomocysteinemia. Physiol. Res. 54 (2005) 87-95
40. Reynolds E.H. Folic acid, ageing, depression and dementia. BMJ 324 (2002) 1512-1515
41. Reis E.A., Zugno A.I., Franzon R., Tagliari B., Matté C., Lammers M.L., Netto C.A., and Wyse A.T.S. Pretreatment with Vitamins E and C prevent the impairment of memory caused by homocysteine administration in rats. Metab. Brain Dis. 17 (2002) 211-217
42. Rydlewicz A., Simpson J.A., Taylor R.J., Bond C.M., and Golden M.H.N. The effect of folic acid supplementation on plasma homocyteine in an elderly population. Quart. J. Med. 95 (2002) 27-35
43. Schurr A., Payne R.S., Heine M.F., and Rigor B.M. Hypoxia, excitotoxicity and neuroprotection in the hippocampal slice preparation. J. Neurosci. Meth. 59 (1995) 129-138
44. Shea T.B., Rogers E., Ashline D., Ortiz D., and Sheu M.S. Apolipoprotein E deficiency promotes increased oxidative stress and compensatory increases in antioxidants in brain tissue. Free Radic. Biol. Med. 33 (2002) 1115-1120
45. Sies H., Stahl W., and Sundquist A.R. Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, other carotenoids. Am. J. Clin. Nutr. 62 (1995) 1315S-1321S
46. Siqueira I.R., Cimarosti H., Fochesatto C., Salbego C., and Netto C.A. Age-related susceptibility to oxygen and glucose deprivation damage in rat hippocampal slices. Brain Res. 1025 (2004) 226-230
47. Stefanello F.M., Franzon R., Tagliari B., Wannmacher C.M.D., Wajner M., and Wyse A.T.S. Reduction of butyrylcholinesterase activity in rat serum subjected to hyperhomocysteinemia. Metab. Brain Dis. 20 (2005) 97-103
48. Streck E.L., Matté C., Vieira P.S., Rombaldi F., Wannmacher C.M.D., Dutra-Filho C.S., Wajner M., and Wyse A.T.S. Reduction of Na(+),K(+)-ATPase activity in hippocampus of rats subjected to chemically induced hyperhomocysteinemia. Neurochem. Res. 27 (2002) 1593-1598
49. Streck E.L., Matté C., Vieira P.S., Calcagnotto T., Wannmacher C.M.D., Wajner M., and Wyse A.T.S. Impairment of energy metabolism in hippocampus of rats subjected to chemically-induced hyperhomocysteinemia. Biochim. Biophys. Acta 1637 (2003) 187-192
50. Streck E.L., Vieira P.S., Wannmacher C.M.D., Dutra-Filho C.S., Wajner M., and Wyse A.T.S. In vitro effect of homocysteine on some parameters of oxidative stress in rat hippocampus. Metab. Brain Dis. 18 (2003) 147-154
51. Streck E.L., Bavaresco C.S., Netto C.A., and Wyse A.T.S. Chronic hyperhomocysteinemia provokes a memory deficit in rats in the Morris water maze task. Behav. Brain Res. 153 (2004) 377-381
52. Taylor C.P., Burke S.P., and Weber M.L. Hippocampal slices: glutamate overflow and cellular damage from ischemia are reduced by sodium channel blockade. J. Neurosci. Meth. 59 (1995) 121-128
53. Tucker J.M., and Townsend D.M. Alpha-tocopherol: roles in prevention and therapy of human disease. Biomed. Pharmacother. 59 (2005) 380-387
54. Ullegaddi R., Powers H.J., and Gariballa S. B-group vitamin supplementation mitigates oxidative damage after acute ischaemic stroke. Clin. Sci. 107 (2004) 477-484
55. Van Beynum I.M., Smeitink J.A.M., Den Heijer M.T.W.B., te Poele Pothoff H., and Blom J. Hyperhomocysteinemia, a risk factor for ischemic stroke in children. Circulation 99 (1999) 2070-2072
56. Van der Worp H.B., Bar P.R., Kappelle L.J., and de Wildt D.J. Dietary Vitamin E levels affect outcome of permanent focal cerebral ischemia in rats. Stroke 29 (1998) 1002-1006
57. Verhaar M.C., Stroes E., and Rabelink T.J. Folates and cardiovascular disease. Arterioscler. Thromb. Vasc. Biol. 22 (2002) 6-13
58. Walter J.H., Wraith J.E., White F.J., Bridge C., and Till J. Strategies for the treatment of cystathionine beta-synthase deficiency: the experience of the Willink Biochemical Genetics Unit over the past 30 years. Eur. J. Pediatr. 157 (1998) 71-76
59. Wang X., and Quinn P.J. Vitamin E and its function in membranes. Prog. Lipid Res. 38 (1999) 309-336
60. Warner D.S., Sheng H., and Batinié-Haberle I. Oxidants, antioxidants and the ischemic brain. J. Exp. Biol. 207 (2004) 3221-3231
61. White A.R., Huang X., Jobling M.F., Barrow C.J., Beyreuther K., Masters C.L., Bush A.I., and Cappai R. Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways. J. Neurochem. 76 (2001) 1509-1520
62. White B.C., Sullivan J.M., DeGracia D.J., O'Neil B.J., Neumar R.W., Grossman L.I., Rafols J.A., and Krause G.S. Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. J. Neurol. Sci. 179 (2000) 1-33
63. +-ATPase activity in hippocampus of rats subjected to acute administration of homocysteine is prevented by Vitamins E and C treatment. Neurochem. Res. 27 (2002) 1685-1689
64. Wyse A.T., Stefanello F.M., Chiarani F., Delwing D., Wannmacher C.M., and Wajner M. Arginine administration decreases cerebral cortex acetylcholinesterase and serum butyrylcholinesterase probably by oxidative stress induction. Neurochem. Res. 19 (2004) 385-389
65. Yoo J.H., Chung C.S., and Kang S.S. Relation of plasma homocyst(e)ine to cerebral infarction and cerebral atherosclerosis. Stroke 29 (1998) 2478-2483
66. Zhang B., Tanaka J., Yang L., Sakanaka M., Hata R., Maeda N., and Mitsuda N. Protective effect of Vitamin E against focal brain ischemia and neuronal death through induction of target genes of hipoxia-inducible factor-1. Neuroscience 126 (2004) 433-440