Inhibition of Na+,K+-ATpase activity in hippocampus of rats subjected to acute administration of homocysteine is prevented by vitamins E and C treatment

Neurochemical Research

Volumn 27, Issue 12, 2002, Pages 1685-1689

  Wyse, Angela T S ^a   Zugno, Alexandra I ^a   Streck, Emilio L ^a   Matté, Cristiane ^a   Calcagnotto, Thiago ^a   Wannmacher, Clovis M D ^a   Wajner, Moacir ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Catalase; Homocysteine; Na+,K+ ATPase; Vitamins E and C

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CATALASE; GLUTATHIONE; HOMOCYSTEINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HIPPOCAMPUS; HOMOCYSTINURIA; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SYNAPSE;

ANIMALS; ASCORBIC ACID; CATALASE; GLUTATHIONE PEROXIDASE; HIPPOCAMPUS; HOMOCYSTEINE; NA(+)-K(+)-EXCHANGING ATPASE; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; VITAMIN E;

ANIMALIA; FELIS CATUS; HIPPOCAMPUS HIPPOCAMPUS;

EID: 0036912033     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1021647329937     Document Type: Article

References (32)

1. Mudd, S. H., Levy, H. L., and Skovby, F. 2001. Disorders of transsulfuration. Pages 1279-1327, in Scriver, C. R., Beaudet, A. L., Sly, W. S., and Valle, D. (eds). The Metabolic and Molecular Bases of Inherited Disease, 8th Ed. McGraw-Hill, New York.
2. Erecinska, M. and Silver, I. A. 1994. Ions and energy in mammalian brain. Prog. Neurobiol. 16:37-71.
3. Lees, G. J. 1993. Contributory mechanisms in the causation of neurodegenerative disorders. Neuroscience 54:287-322.
4. +-ATPase activity after brain ischemia. Neurochem. Res. 25:969-973.
5. + pump in epilepsy. Ann. Neurol. 16 (Suppl):128-134.
6. Halliwell, B. and Gutteridge, J. M. C. 1985. Oxygen radicals in the nervous system. Trends Neurosci. 8:22-26.
7. Welch, G. N., Upchurch, G. R., and Loscalzo, J. 1997. Homocysteine, oxidative stress and vascular disease. Hosp. Pract. 32:81-92.
8. Hogg, N. 1999. The effect of cyst(e)ine on the auto-oxidation of homocysteine. Free Radical Biol. Med. 27:28-33.
9. Kubová, H., Folbergrová, J., and Mares, P. 1995. Seizures induced by homocysteine in rats during ontogenesis. Epilepsia 36: 750-756
10. +-ATPase activity induced by homocysteine is probably mediated by oxidative stress. Neurochem. Res. 26:1195-1200.
11. Fighera, M. R., Queiroz, C. M., Stracke, M. P., Brauer, M. L. N., González-Rodrigues, L. L., Frussa-Filho, R., Wajner, M., and Mello, C. F. 1999. Ascorbic acid and α-tocopherol attenuate methylmalonic acid-induced convulsions. NeuroReport 10:2039-2043.
12. Jones, D. H. and Matus, A. I. 1974, Isolation of plasma synaptic membrane from brain by combination flotation-sedimentation density gradient centrifugation. Biochim. Biophys. Acta 356:276-287.
13. +)-stimulated ATPase and acetylcholinesterase activities of dog brain synaptosomal plasma membranes. Biochem. J. 22:301-307.
14. 2+-stimulated ATPase activity. Anal. Biochem. 157:375-380.
15. Lissi, E., Pascual, C., and del Castillo, M. D. 1992. Luminol luminescence induced by 2,2′-azo-bis(2-amidopropane) thermolysis. Free Rad. Res. Comm. 17:299-311.
16. Aebi, H. 1984. Catalase in vitro. Methods Enzymol. 105:121-126.
17. Wendel, A. 1981. Glutathione peroxidase. Methods Enzymol. 77:325-332.
18. Lowry, O. K., Rosenbrough, R.L., Farr, R. L., and Randall, R. J. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275.
19. Fuchs, D., Jaeger, M., Widner, B., Wirleitner, B., Artner-Dworzak, E., and Leblhuber, F. 2001. Is hyperhomocysteinemia due to the oxidative depletion of folate rather than to insufficient dietary intake? Clin. Chem. Lab. Med. 39:691-694.
20. Ames, B. N., Shigenaga, M. K., and Hagen, T. M. 1993. Oxidants, antioxidants and the degenerative diseases of aging. Proc. Natl. Acad. Sci. U.S.A. 90:7915-7922.
21. Jacobsen, D. J. 2000. Hyperhomocysteinemia and oxidative stress. Time for a reality check? Arterioscler. Thromb. Vasc. Biol. 20:1182-1184.
22. Malinow, M. R. 1990. Hyperhomocyst(e)inemia. A common and easily reversible risk factor for occlusive atherosclerosis. Circulation 81:2004-2006.
23. Hitschke, K., Buhler, R., Apell, H. J., and Stark G. 1994. Inactivation of the Na,K-ATPase by radiation-induced free radicals. Evidence for a radical-chain mechanism. FEBS Lett. 353:297-300.
24. Burton, G. W., Wronska, U., Stone, L., Foster, D. O., and Ingold, K. U. 1990. Biokinetics of dietary RRR-α-tocopherol in the male guinea-pig at three dietary levels of vitamin C and two levels of vitamin E. Lipids 25:199-210.
25. McCay, P. B. 1985. Vitamin E: Interactions with free radical and ascorbate. Annu. Rev. Nutr. 5:323-340.
26. Frei, B., Stocker, R., England, L., and Ames, B. N. 1990. Ascorbate: The most effective antioxidant in the blood. Adv. Exp. Med. Biol. 264:155-163.
27. Carr, A. and Frei, B. 1999. Does vitamin C act as a pro-oxidant under physiological conditions? FASEB J. 13:1007-1024.
28. Hara, H., Kato, H., and Kogure, K. 1990. Protective effect of alpha-tocopherol on ischemic neuronal damage in the gerbil hippocampus. Brain Res. 510:335-338.
29. Anderson, D. K., Waters, T. R., and Means, E. D. 1988, Pre-treatment with alpha-tocopherol enhances neurologic recovery after experimental spinal cord compression injury. J. Neurotrauma 5:61-67.
30. Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, S., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., Schneider, L. S., and Thal, L. J. 1997. A controlled trial of selegiline, α-tocopherol, or both as treatment for Alzheimer's disease. N. Engl. J. Med. 336:1216-1222.
31. Allen, I. C., Grieve, A., and Griffiths, R. 1986. Differential changes in the content of amino acid neurotransmitters in discrete regions of the rat brain prior to the onset and during the course of homocysteine-induced seizures. J. Neurochem. 46:1582-1592.
32. Kim, W.-K., and Pae, Y.-S. 1996. Involvement of N-methyl-D-aspartate receptor and free radical in homocysteine-mediated toxicity on rat cerebellar granule cells in culture. Neurosci. Lett. 216:17-120.