Molecular basis of the time-dependent inhibition of cyclooxygenases by indomethacin

Biochemistry

Volumn 43, Issue 49, 2004, Pages 15439-15445

  Prusakiewicz, Jeffery J ^a   Felts, Andrew S ^a   Mackenzie, Bonnie S ^a   Marnett, Lawrence J ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; DRUG PRODUCTS; FLUORESCENCE; HYDROPHOBICITY; MUTAGENESIS; QUENCHING; REACTION KINETICS; SYNTHESIS (CHEMICAL);

ANTIINFLAMMATORY DRUGS; ARACHIDONIC ACID; CYCLOOXYGENASES (COX); INDOMETHACIN;

ENZYME INHIBITION;

ARACHIDONIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; INDOMETACIN; INDOMETACIN DERIVATIVE; PROSTAGLANDIN SYNTHASE;

ARTICLE; CHEMICAL REACTION KINETICS; ENZYME INHIBITION; PRIORITY JOURNAL;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; INDOMETHACIN; ISOENZYMES; KINETICS; MALE; MICE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SHEEP; SPECTROMETRY, FLUORESCENCE; SUBSTRATE SPECIFICITY; TIME FACTORS;

EID: 10644285687     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi048534q     Document Type: Article

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