Computer-assisted design of selective imidazole inhibitors for cytochrome P450 enzymes

Journal of Medicinal Chemistry

Volumn 47, Issue 14, 2004, Pages 3572-3579

  Verras, Andreas ^a   Kuntz, Irwin D ^a   Ortiz De Montellano, Paul R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; COORDINATION COMPOUND; CYTOCHROME P450; CYTOCHROME P450 INHIBITOR; HEME; IMIDAZOLE DERIVATIVE; LEUCINE; MUTANT PROTEIN; PYRROLE DERIVATIVE; RECOMBINANT ENZYME;

ALGORITHM; ARTICLE; BINDING AFFINITY; CHEMICAL BOND; COMPUTER AIDED DESIGN; CONTROLLED STUDY; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; IC 50; MODEL; NONHUMAN; SPECTROSCOPY;

COMPUTER-AIDED DESIGN; CYTOCHROME P-450 ENZYME SYSTEM; DATABASES, FACTUAL; DRUG DESIGN; ENZYME INHIBITORS; IMIDAZOLES; MUTATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 3042645255     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030608t     Document Type: Article

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