The 1.92-Å structure of Streptomyces coelicolor A3(2) CYP154C1: A new monooxygenase that functionalizes macrolide ring systems

Journal of Biological Chemistry

Volumn 278, Issue 14, 2003, Pages 12214-12221

  Podust, Larissa M ^a,e   Kim, Youngchang ^b   Arase, Miharu ^a   Neely, Benjamin A ^a   Beck, Brian J ^c   Bach, Horacio ^c   Sherman, David H ^c   Lamb, David C ^d   Kelly, Steven L ^d   Waterman, Michael R ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ARGONNE NATIONAL LABORATORY   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d ABERYSTWYTH UNIVERSITY   (United Kingdom)

^e VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BIOREMEDIATION; CATALYSIS; OXIDATION; SUBSTRATES;

MACROLIDE ANTIBIOTICS;

PROTEINS;

CYTOCHROME P450 154C1; CYTOCHROME P450 ISOENZYME; HEME; LACTONE; MACROLIDE; OXYGEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOL DERIVATIVE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; CYTOCHROME P450; MIXED FUNCTION OXIDASE; NARBOMYCIN; YC 17 MACROLIDE; YC-17 MACROLIDE;

AMINO ACID SEQUENCE; ANTIBIOTIC BIOSYNTHESIS; ANTIMICROBIAL ACTIVITY; ARTICLE; BETA SHEET; BINDING SITE; BIOREMEDIATION; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ENGINEERING; ENZYME SPECIFICITY; MOLECULAR EVOLUTION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; SEQUENCE HOMOLOGY; STEREOCHEMISTRY; STREPTOMYCES COELICOLOR; X RAY CRYSTALLOGRAPHY; CHEMISTRY; CRYSTALLOGRAPHY; ELECTRICITY; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; STREPTOMYCES; STRUCTURE ACTIVITY RELATION;

ACTINOBACTERIA (CLASS); STREPTOMYCES; STREPTOMYCES COELICOLOR; UNCULTURED ACTINOMYCETE;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BINDING SITES; CRYSTALLOGRAPHY; CYTOCHROME P-450 ENZYME SYSTEM; ELECTROSTATICS; MACROLIDES; MIXED FUNCTION OXYGENASES; MOLECULAR SEQUENCE DATA; OXYGEN; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; STREPTOMYCES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037809271     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M212210200     Document Type: Article

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