-
1
-
-
0037097593
-
Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40:CD40L costimulatory pathway results in the generation of a potent immune regulatory cell
-
Taylor PA, Friedman TM, Korngold R, et al. Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40:CD40L costimulatory pathway results in the generation of a potent immune regulatory cell. Blood 2002;99:4601-9.
-
(2002)
Blood
, vol.99
, pp. 4601-4609
-
-
Taylor, P.A.1
Friedman, T.M.2
Korngold, R.3
-
2
-
-
2242423605
-
CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
-
Belkaid Y, Piccirillo CA, Mendez S, et al. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 2002;420:502-7.
-
(2002)
Nature
, vol.420
, pp. 502-507
-
-
Belkaid, Y.1
Piccirillo, C.A.2
Mendez, S.3
-
3
-
-
22244462396
-
Regulatory T cells in immunologie self-tolerance and autoimmune disease
-
Sakaguchi S, Sakaguchi N. Regulatory T cells in immunologie self-tolerance and autoimmune disease. Int Rev Immunol 2005;24:211-26.
-
(2005)
Int Rev Immunol
, vol.24
, pp. 211-226
-
-
Sakaguchi, S.1
Sakaguchi, N.2
-
4
-
-
0034679567
-
Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation
-
Read S, Malmstrom V, Powrie F. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J Exp Med 2000;192:295-302.
-
(2000)
J Exp Med
, vol.192
, pp. 295-302
-
-
Read, S.1
Malmstrom, V.2
Powrie, F.3
-
5
-
-
0037446531
-
Cutting edge: Cure of colitis by CD4+CD25+ regulatory T cells
-
Mottet C, Uhlig HH, Powrie F. Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J Immunol 2003;170:3939-43.
-
(2003)
J Immunol
, vol.170
, pp. 3939-3943
-
-
Mottet, C.1
Uhlig, H.H.2
Powrie, F.3
-
7
-
-
4344682025
-
CD4+CD25bright T cells in human intestinal lamina propria as regulatory cells
-
Makita S, Kanai T, Oshima S, et al. CD4+CD25bright T cells in human intestinal lamina propria as regulatory cells. J Immunol 2004;173:3119-30.
-
(2004)
J Immunol
, vol.173
, pp. 3119-3130
-
-
Makita, S.1
Kanai, T.2
Oshima, S.3
-
8
-
-
1842732224
-
Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis
-
Viglietta V, Baecher-Allan C, Weiner HL, et al. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med 2004;199:971-9.
-
(2004)
J Exp Med
, vol.199
, pp. 971-979
-
-
Viglietta, V.1
Baecher-Allan, C.2
Weiner, H.L.3
-
9
-
-
0029788211
-
Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
-
Asano M, Toda M, Sakaguchi N, et al. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J Exp Med 1996;184:387-96.
-
(1996)
J Exp Med
, vol.184
, pp. 387-396
-
-
Asano, M.1
Toda, M.2
Sakaguchi, N.3
-
10
-
-
25844504653
-
Developmental regulation of Foxp3 expression during ontogeny
-
Fontenot JD, Dooley JL, Farr AG, et al. Developmental regulation of Foxp3 expression during ontogeny. J Exp Med 2005;202:901-6.
-
(2005)
J Exp Med
, vol.202
, pp. 901-906
-
-
Fontenot, J.D.1
Dooley, J.L.2
Farr, A.G.3
-
11
-
-
17144400393
-
TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells
-
Marie JC, Letterio JJ, Gavin M, et al. TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells. J Exp Med 2005;201:1061-7.
-
(2005)
J Exp Med
, vol.201
, pp. 1061-1067
-
-
Marie, J.C.1
Letterio, J.J.2
Gavin, M.3
-
12
-
-
27544446622
-
Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling
-
D'Cruz LM, Klein L. Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling. Nat Immunol 2005;6:1152-9.
-
(2005)
Nat Immunol
, vol.6
, pp. 1152-1159
-
-
D'Cruz, L.M.1
Klein, L.2
-
13
-
-
0035320679
-
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide
-
Jordan MS, Boesteanu A, Reed AJ, et al. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat Immunol 2001;2:301-6.
-
(2001)
Nat Immunol
, vol.2
, pp. 301-306
-
-
Jordan, M.S.1
Boesteanu, A.2
Reed, A.J.3
-
14
-
-
0035920510
-
Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells
-
Bensinger SJ, Bandeira A, Jordan MS, et al. Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells. J Exp Med 2001;194:427-38.
-
(2001)
J Exp Med
, vol.194
, pp. 427-438
-
-
Bensinger, S.J.1
Bandeira, A.2
Jordan, M.S.3
-
15
-
-
13944260538
-
CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
-
Tai X, Cowan M, Feigenbaum L, et al. CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat Immunol 2005;6:152-62.
-
(2005)
Nat Immunol
, vol.6
, pp. 152-162
-
-
Tai, X.1
Cowan, M.2
Feigenbaum, L.3
-
16
-
-
24144480562
-
Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus
-
Watanabe N, Wang YH, Lee HK, et al. Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus. Nature 2005;436:1181-5.
-
(2005)
Nature
, vol.436
, pp. 1181-1185
-
-
Watanabe, N.1
Wang, Y.H.2
Lee, H.K.3
-
17
-
-
11244291391
-
Functional defect of regulatory CD4(+)CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis
-
Balandina A, Lecart S, Dartevelle P, et al. Functional defect of regulatory CD4(+)CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis. Blood 2005;105:735-41.
-
(2005)
Blood
, vol.105
, pp. 735-741
-
-
Balandina, A.1
Lecart, S.2
Dartevelle, P.3
-
18
-
-
2942557115
-
Colitis is associated with thymic destruction attenuating CD4+25+ regulatory T cells in the periphery
-
Faubion WA, De Jong YP, Molina AA, et al. Colitis is associated with thymic destruction attenuating CD4+25+ regulatory T cells in the periphery. Gastroenterology 2004;126:1759-70.
-
(2004)
Gastroenterology
, vol.126
, pp. 1759-1770
-
-
Faubion, W.A.1
De Jong, Y.P.2
Molina, A.A.3
-
19
-
-
2542420993
-
In vivo instruction of suppressor commitment in naive T cells
-
Apostolou I, von Boehmer H. In vivo instruction of suppressor commitment in naive T cells. J Exp Med 2004;199:1401-8.
-
(2004)
J Exp Med
, vol.199
, pp. 1401-1408
-
-
Apostolou, I.1
Von Boehmer, H.2
-
20
-
-
2142645808
-
Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7
-
Fantini MC, Becker C, Monteleone G, et al. Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. J Immunol 2004;172:5149-53.
-
(2004)
J Immunol
, vol.172
, pp. 5149-5153
-
-
Fantini, M.C.1
Becker, C.2
Monteleone, G.3
-
21
-
-
0348223787
-
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
-
Chen W, Jin W, Hardegen N, et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003;198:1875-86.
-
(2003)
J Exp Med
, vol.198
, pp. 1875-1886
-
-
Chen, W.1
Jin, W.2
Hardegen, N.3
-
22
-
-
4744356110
-
TGF-beta induces Foxp3 + T-regulatory cells from CD4+ CD25-precursors
-
Fu S, Zhang N, Yopp AC, et al. TGF-beta induces Foxp3 + T-regulatory cells from CD4+ CD25-precursors. Am J Transplant 2004;4:1614-27.
-
(2004)
Am J Transplant
, vol.4
, pp. 1614-1627
-
-
Fu, S.1
Zhang, N.2
Yopp, A.C.3
-
23
-
-
0346969978
-
Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells
-
Walker MR, Kasprowicz DJ, Gersuk VH, et al. Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells. J Clin Invest 2003;112:1437-43.
-
(2003)
J Clin Invest
, vol.112
, pp. 1437-1443
-
-
Walker, M.R.1
Kasprowicz, D.J.2
Gersuk, V.H.3
-
24
-
-
33646251141
-
Transforming growth factor β induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis
-
Fantini MC, Becker C, Tubbe I, et al. Transforming growth factor β induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis. Gut 2006;55:671-80.
-
(2006)
Gut
, vol.55
, pp. 671-680
-
-
Fantini, M.C.1
Becker, C.2
Tubbe, I.3
-
25
-
-
29244435493
-
Inducing and expanding regulatory T cell populations by foreign antigen
-
Kretschmer K, Apostolou I, Hawiger D, et al. Inducing and expanding regulatory T cell populations by foreign antigen. Nat Immunol 2005;6:1219-27.
-
(2005)
Nat Immunol
, vol.6
, pp. 1219-1227
-
-
Kretschmer, K.1
Apostolou, I.2
Hawiger, D.3
-
26
-
-
27544481941
-
A function for interleukin 2 in Foxp3-expressing regulatory T cells
-
Fontenot JD, Rasmussen JP, Gavin MA, et al. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 2005;6:1142-51.
-
(2005)
Nat Immunol
, vol.6
, pp. 1142-1151
-
-
Fontenot, J.D.1
Rasmussen, J.P.2
Gavin, M.A.3
-
27
-
-
18844371714
-
Regulation of CD4+CD25+ regulatory T cell activity: It takes (IL-)two to tango
-
Scheffold A, Huhn J, Hofer T. Regulation of CD4+CD25+ regulatory T cell activity: it takes (IL-)two to tango. Eur J Immunol 2005;35:1336-41.
-
(2005)
Eur J Immunol
, vol.35
, pp. 1336-1341
-
-
Scheffold, A.1
Huhn, J.2
Hofer, T.3
-
28
-
-
2442637772
-
Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function
-
Thornton AM, Donovan EE, Piccirillo CA, et al. Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function. J Immunol 2004;172:6519-23.
-
(2004)
J Immunol
, vol.172
, pp. 6519-6523
-
-
Thornton, A.M.1
Donovan, E.E.2
Piccirillo, C.A.3
-
29
-
-
0034894059
-
Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease
-
Monteleone G, Kumberova A, Croft NM, et al. Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease. J Clin Invest 2001;108:601-9.
-
(2001)
J Clin Invest
, vol.108
, pp. 601-609
-
-
Monteleone, G.1
Kumberova, A.2
Croft, N.M.3
-
30
-
-
0035801335
-
Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta
-
Nakamura K, Kitani A, Strober W. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med 2001;194:629-44.
-
(2001)
J Exp Med
, vol.194
, pp. 629-644
-
-
Nakamura, K.1
Kitani, A.2
Strober, W.3
-
31
-
-
0037099613
-
CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness
-
Piccirillo CA, Letterio JJ, Thornton AM, et al. CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness. J Exp Med 2002;196:237-46.
-
(2002)
J Exp Med
, vol.196
, pp. 237-246
-
-
Piccirillo, C.A.1
Letterio, J.J.2
Thornton, A.M.3
-
32
-
-
1642577126
-
TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice
-
Nakamura K, Kitani A, Fuss I, et al. TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice. J Immunol 2004;172:834-42.
-
(2004)
J Immunol
, vol.172
, pp. 834-842
-
-
Nakamura, K.1
Kitani, A.2
Fuss, I.3
-
33
-
-
15444363794
-
T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells
-
Fahlen L, Read S, Gorelik L, et al. T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells. J Exp Med 2005;201:737-46.
-
(2005)
J Exp Med
, vol.201
, pp. 737-746
-
-
Fahlen, L.1
Read, S.2
Gorelik, L.3
-
34
-
-
27644590054
-
TGF-beta1 production by CD4+ CD25+ regulatory T cells is not essential for suppression of intestinal inflammation
-
Kullberg MC, Hay V, Cheever AW, et al. TGF-beta1 production by CD4+ CD25+ regulatory T cells is not essential for suppression of intestinal inflammation. Eur J Immunol 2005;35:2886-95.
-
(2005)
Eur J Immunol
, vol.35
, pp. 2886-2895
-
-
Kullberg, M.C.1
Hay, V.2
Cheever, A.W.3
-
35
-
-
0141703239
-
CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes
-
Green EA, Gorelik L, McGregor CM, et al. CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes. Proc Natl Acad Sci U S A 2003;100:10878-83.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 10878-10883
-
-
Green, E.A.1
Gorelik, L.2
McGregor, C.M.3
-
36
-
-
12244285937
-
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo
-
Chen ML, Rittet MJ, Gorelik L, et al. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc Natl Acad Sci U S A 2005;102:419-24.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 419-424
-
-
Chen, M.L.1
Rittet, M.J.2
Gorelik, L.3
-
37
-
-
0035806323
-
Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
-
Levings MK, Sangregorio R, Roncarolo MG. Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 2001;193:1295-302.
-
(2001)
J Exp Med
, vol.193
, pp. 1295-1302
-
-
Levings, M.K.1
Sangregorio, R.2
Roncarolo, M.G.3
-
38
-
-
20444374502
-
CD27/CFSE-based ex vivo selection of highly suppressive alloantigen-specific human regulatory T cells
-
Koenen HJ, Fasse E, Joosten I. CD27/CFSE-based ex vivo selection of highly suppressive alloantigen-specific human regulatory T cells. J Immunol 2005;174:7573-83.
-
(2005)
J Immunol
, vol.174
, pp. 7573-7583
-
-
Koenen, H.J.1
Fasse, E.2
Joosten, I.3
-
39
-
-
3242801352
-
Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells
-
Hoffmann P, Eder R, Kunz-Schughart LA, et al. Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells. Blood 2004;104:895-903.
-
(2004)
Blood
, vol.104
, pp. 895-903
-
-
Hoffmann, P.1
Eder, R.2
Kunz-Schughart, L.A.3
-
40
-
-
14044278784
-
Generation of antigen-specific, Foxp3-expressing CD4+ regulatory T cells by inhibition of APC proteosome function
-
Cong Y, Konrad A, Iqbal N, et al. Generation of antigen-specific, Foxp3-expressing CD4+ regulatory T cells by inhibition of APC proteosome function. J Immunol 2005;174:2787-95.
-
(2005)
J Immunol
, vol.174
, pp. 2787-2795
-
-
Cong, Y.1
Konrad, A.2
Iqbal, N.3
-
41
-
-
14044259353
-
Augmented induction of CD4+CD25+ Treg using monoclonal antibodies to CD200R
-
Gorczynski RM, Lee L, Boudakov I. Augmented induction of CD4+CD25+ Treg using monoclonal antibodies to CD200R. Transplantation 2005,79:1180-3.
-
(2005)
Transplantation
, vol.79
, pp. 1180-1183
-
-
Gorczynski, R.M.1
Lee, L.2
Boudakov, I.3
-
42
-
-
18144387626
-
Induction of CD4+CD25+ regulatory T cells by copolymer-I through activation of transcription factor Foxp3
-
Hong J, Li N, Zhang X, et al. Induction of CD4+CD25+ regulatory T cells by copolymer-I through activation of transcription factor Foxp3. Proc Natl Acad Sci U S A 2005;102:6449-54.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 6449-6454
-
-
Hong, J.1
Li, N.2
Zhang, X.3
-
43
-
-
12744262844
-
Antigen-specific FoxP3-transduced T-cells can control established type 1 diabetes
-
Jaeckel E, von Boehmer H, Manns M. Antigen-specific FoxP3-transduced T-cells can control established type 1 diabetes. Diabetes 2005;54:306-10.
-
(2005)
Diabetes
, vol.54
, pp. 306-310
-
-
Jaeckel, E.1
Von Boehmer, H.2
Manns, M.3
|