Synthesis and biological evaluation of heteroaryldiamides and heteroaryldiamines as cytotoxic agents, apoptosis inducers and caspase-3 activators

Archiv der Pharmazie

Volumn 339, Issue 4, 2006, Pages 182-192

  Echeverría, Mikel ^a   Mendívil, Beatriz ^a   Cordeu, Lucía ^b   Cubedo, Elena ^b   García Foncillas, Jesús ^b   Font, María ^a   Sanmartín, Carmen ^a   Palop, Juan Antonio ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

Apoptosis; Caspase 3; Cytotoxicity; Heteroaryldiamides; Heteroaryldiamines

Indexed keywords

1,4 BIS(PYRIDIN 2 YLMETHYL)PIPERAZINE; 2 QUINOLINIC ACID; 3 QUINOLINIC ACID; APOPTOSIS INDUCING FACTOR; BENZENE; BIS(1 AMINOPYRIDINIUM)DERIVATIVE; CASPASE 3; CYTOTOXIC AGENT; DIAMINE; DIQUINOLINE DIOXIDE; ENZYME ACTIVATOR; INDOLE; N,N' BIS[3 (PYRIDO[2,3 D]PYRIMIDIN 4 YLAMINO)PROPYL]BUTANE 1,4 DIAMINE; PIPERAZINE; PIPERAZINE DERIVATIVE; POLYAMINE; PYRIDINE; PYRIDINIUM DERIVATIVE; PYRIDO[2,3 D]PYRIMIDINE DERIVATIVE; QUINOLINE DERIVATIVE; QUINOLINIC ACID DERIVATIVE; QUINOLONE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BLADDER CANCER; BREAST CANCER; COLON CANCER; CONTROLLED STUDY; DOSE RESPONSE; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL;

AMIDES; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASES; CELL LINE, TUMOR; CELL SURVIVAL; DIAMINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HT29 CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33646127349     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200500220     Document Type: Article

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