Effects of treatment of rats with indole-3-carbinol on apoptosis in the mammary gland and mammary adenocarcinomas

Anticancer Research

Volumn 23, Issue 3 B, 2003, Pages 2473-2479

  Zhang, Xuexian ^a,b   Malejka Giganti, Danuta ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; Indole 3 carbinol; Mammary adenocarcinoma; Mammary gland

Indexed keywords

3 INDOLEMETHANOL; 7,12 DIMETHYLBENZ[A]ANTHRACENE; CARCINOGEN; CASPASE 3; CASPASE 8; CASPASE 9; CORN OIL;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST ADENOCARCINOMA; BREAST CARCINOGENESIS; BREAST CARCINOMA; CANCER PREVENTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; FEMALE; MAMMARY GLAND; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ADENOCARCINOMA; ANIMALS; ANTICARCINOGENIC AGENTS; APOPTOSIS; BETA-NAPHTHOFLAVONE; CARCINOGENS; FEMALE; INDOLES; MAMMARY GLANDS, ANIMAL; MAMMARY NEOPLASMS, EXPERIMENTAL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0042306526     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Verhoeven DTH, Verhagen H, Goldbohm RA, Vanden Brandt PA and Van Poppel G: A review of mechanisms underlying anticarcinogenicity of brassica vegetables. Chem-Biol Interact 103: 79-129, 1997.
2. Wattenberg LW and Leong JL: Inhibition of the carcinogenic action of 7,12-dimethylbenz(a)anthracene by beta-naphthoflavone. Proc Soc Exp Biol Med 128: 940-943, 1968.
3. Bjeldanes LF, Kim J-Y, Grose KR, Bartholomew JC and Bradfield CA: Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: Comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Proc Natl Acad Sci USA 88: 9543-9547, 1991.
4. Jellinck PH, Forkert PG, Riddick DS, Okey AB, Michnovicz JJ and Bradlow HL: Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem Pharmacol 45: 1129-1136, 1993.
5. Safe SH: Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Pharmac Ther 67: 247-281, 1995.
6. Cantrell SM, Joy-Schlezinger J, Stegeman JJ, Tillitt DE and Hannink M: Correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced apoptotic cell death in the embryonic vasculature with embryotoxicity. Toxicol Appl Pharmacol 148: 24-34, 1998.
7. Weber LP and Janz DM: Effect of β-naphthoflavone and dimethylbenz[α]anthracene on apoptosis and HSP70 expression in juvenile channel catfish (Ictalurus punctatus) ovary. Aquat Toxicol 54: 39-50, 2001.
8. Dong W, Teraoka H, Kondo S and Hiraga T: 2,3,7,8-tetrachlorodibenzo-p-dioxin induces apoptosis in the dorsal midbrain of zebrafish embryos by activation of arylhydrocarbon receptor. Neuroscience Lett 303: 169-172, 2001.
9. Telang NT, Katdare M, Bradlow HL, Osborne MP and Fishman J: Inhibition of proliferation and modulation of estradiol metabolism: novel mechanisms for breast cancer prevention by the phytochemical indole-3-carbinol. Proc Soc Exp Biol Med 216: 246-252, 1997.
10. Cover CM, Hsieh SJ, Tran SH, Hallden G, Kim GS, Bjeldanes LF and Firestone GL: Indole-3-carbinol inhibits the expression of cyclin-dependent kinase-6 and induces a G1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling. J Biol Chem 273: 3838-3847, 1998.
11. Cram EJ, Liu BD, Bjeldanes LF and Firestone GL: Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter. J Biol Chem 276: 22332-22340, 2001.
12. 1 cell cycle arrest and apoptosis in prostate cancer cells. Oncogene 20: 2927-2936, 2001.
13. Rahman KMW, Aranha O, Glazyrin A, Chinni SR and Sarkar FH: Translocation of Bax to mitochondria induces apoptotic cell death in indole-3-carbinol (I3C) treated breast cancer cells. Oncogene 19: 5764-5771, 2000.
14. Chinni SR and Sarkar FH: Akt inactivation is a key event in indole-3-carbinol-induced apoptosis in PC-3 cells. Clin Canc Res 8: 1228-1236, 2002.
15. Ge X, Fares FA and Yannai S: Induction of apoptosis in MCF-7 cells by indole-3-carbinol is independent of p53 and Bax. Anticancer Res 19: 3199-3204, 1999.
16. Ge X, Yannai S, Rennert G, Gruener N and Fares FA: 3,3′-Diindolylmethane induces apoptosis in human cancer cells. Biochem Biophys Res Commun 228: 153-158, 1996.
17. Hong C, Firestone GL and Bjeldanes LF: Bcl-2 family-mediated apoptotic effects of 3, 3′-diindolylmethane (DIM) in human breast cancer cells. Biochem Pharmacol 63: 1085-1097, 2002.
18. WAF1/CIP1 expression. Carcinogenesis 23: 1297-1305, 2002.
19. Chen I, McDougal A, Wang F and Safe S: Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane. Carcinogenesis 19: 1631-1639, 1998.
20. Stoner G, Casto B, Ralston S, Roebuck B, Pereira C and Bailey G: Development of a multi-organ rat model for evaluating chemopreventive agents: efficacy of indole-3-carbinol. Carcinogenesis 23: 265-272, 2002.
21. Malejka-Giganti D, Niehans GA, Reichert MA and Bliss RL: Post-initiation treatment of rats with indole-3-carbinol or β-naphthoflavone does not suppress 7,12-dimethylbenz[α]anthracene-induced mammary gland carcinogenesis. Cancer Lett 160: 209-218, 2000.
22. Horn TL, Reichert MA, Bliss RL and Malejka-Giganti D: Modulations of P450 mRNA in liver and mammary gland and P450 activities and metabolism of estrogen in liver by treatment of rats with indole-3-carbinol. Biochem Pharmacol 64: 393-404, 2002.
23. Kaufmann SH and Hengartner MO: Programmed cell death: alive and well in the new millennium. Trends Cell Biol 11: 526-534, 2001.
24. Chang YC, Riby J, Chang GH, Peng BC, Firestone G and Bjeldanes LF: Cytostatic and antiestrogenic effects of 2-(indol-3-ylmethyl)-3,3′-diindolylmethane, a major in vivo product of dietary indole-3-carbinol. Biochem Pharmacol 58: 825-834, 1999.
25. Willingham MC: Cytochemical methods for the detection of apoptosis. J Histochem Cytochem 47: 1101-1109, 1999.
26. Oltvai ZN, Milliman CL and Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death. Cell 74: 609-619, 1993.
27. Sedlak TW, Oltvai ZN, Yang E, Wang K, Boise LH, Thompson CB and Korsmeyer SJ: Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc Natl Acad Sci USA 92: 7834-7838, 1995.
28. Grose KR and Bjeldanes LF: Oligomerization of indole-3-carbinol in aqueous acid. Chem Res Toxicol 5: 188-193, 1992.
29. Kyprianou N, English HF, Davidson NE and Isaacs JT: Programmed cell death during regression of the MCF-7 human breast cancer following estrogen ablation. Cancer Res 51: 162-166, 1991.
30. Monroe DG, Berger RR and Sanders MM: Tissue-protective effects of estrogen involve regulation of caspase gene expression. Molec Endocrin 16: 1322-1331, 2002.
31. Ritter CL, Prigge WF, Reichert MA and Malejka-Giganti D: Oxidations of 17β-estradiol and estrone and their interconversions catalyzed by liver, mammary gland and mammary tumor after acute and chronic treatment of rats with indole-3-carbinol or β-naphthoflavone. Can J Physiol Pharmacol 79: 519-532, 2001.
32. Mandlekar S, Hebbar V, Christov K and Kong ANT: Pharmacodynamics of tamoxifen and its 4-hydroxy and N-desmethyl metabolites: activation of caspases and induction of apoptosis in rat mammary tumors and in human breast cancer cell lines. Cancer Res 60: 6601-6606, 2000.