Synthesis and biological activities of bisnaphthalimido polyamines derivatives: Cytotoxicity, DNA binding, DNA damage and drug localization in breast cancer MCF 7 cells

Biochemical Pharmacology

Volumn 69, Issue 1, 2005, Pages 19-27

  Dance, Anne Marie ^a   Ralton, Lynda ^a   Fuller, Zoe ^a   Milne, Lesley ^b   Duthie, Susan ^b   Bestwick, Charles S ^b   Lin, Paul Kong Thoo ^a  

^a ROBERT GORDON UNIVERSITY   (United Kingdom)

^b ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Bisnaphthalimides; Cytotoxicity; DNA binding and damage; Fluorescence microscopy; Single cell gel electrophoresis assay; Synthesis

Indexed keywords

ANTINEOPLASTIC AGENT; BISNAPHTHALIMIDOOXYPROPYLPUTRESCINE; BISNAPHTHALIMIDOOXYPROPYLSPERMIDINE; BISNAPHTHALIMIDOOXYPROPYLSPERMINE; BISNAPHTHALIMIDOPROPYLSPERMIDINE; BISNAPHTHALIMIDOPROPYLSPERMINE; ETHIDIUM BROMIDE; POLYAMINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DNA DENATURATION; DRUG CYTOTOXICITY; DRUG DISTRIBUTION; DRUG DNA BINDING; DRUG SCREENING; DRUG SYNTHESIS; DRUG TRANSPORT; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; POLYAMINE SYNTHESIS; PRIORITY JOURNAL;

BINDING SITES; BREAST NEOPLASMS; CELL LINE, TUMOR; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; NAPHTHALENES; POLYAMINES;

EID: 9944250011     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.09.020     Document Type: Article

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