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Volumn 37, Issue 4, 2002, Pages 301-313
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Synthesis, cytotoxic activities and proposed mode of binding of a series of bis{[(9-oxo-9,10-dihydroacridine-4-carbonyl)amino]alkyl}alkylamines
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Author keywords
Acridine; Anticancer; Bisintercalation; Cytotoxicity; DNA binding; Molecular modelling
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Indexed keywords
ACRIDINE;
ACRIDINE DERIVATIVE;
CISPLATIN;
DOUBLE STRANDED DNA;
ETHIDIUM BROMIDE;
INTERCALATING AGENT;
LIGAND;
N,N BIS[2 [(1 CHLORO 9 OXO 9,10 DIHYDROACRIDINE 4 CARBONYL)AMINO]ETHYL]METHYLAMINE;
N,N BIS[2 [(1 NITRO 9 OXO 9,10 DIHYDROACRIDINE 4 CARBONYL)AMINO]ETHYL]METHYLAMINE;
N,N BIS[3 [(1 CHLORO 9 OXO 9,10 DIHYDROACRIDINE 4 CARBONYL)AMINO]PROPYL]METHYLAMINE;
N,N BIS[3 [(1 NITRO 9 OXO 9,10 DIHYDROACRIDINE 4 CARBONYL)AMINO]PROPYL]METHYLAMINE;
N,N' BIS[2 [(1 AMINO 9 OXO 9,10 DIHYDROACRIDINE 4 CARBONYL)AMINO]ETHYL] N,N' DIMETHYLETHYLENEDIAMINE;
N,N' BIS[2 [(1 AMINO 9 OXO 9,10 DIHYDROACRIDINE 4 CARBONYL)AMINO]ETHYL] N,N' DIMETHYLPROPYLENEDIAMINE;
N,N' BIS[2 [(1 CHLORO 9 OXO 9,10 DIHYDROACRIDINE 4 CARBONYL)AMINO]ETHYL] N,N' DIMETHYLETHYLENEDIAMINE;
N,N' BIS[2 [(1 CHLORO 9 OXO 9,10 DIHYDROACRIDINE 4 CARBONYL)AMINO]ETHYL] N,N' DIMETHYLPROPYLENEDIAMINE;
N,N' BIS[2 [(1 NITRO 9 OXO 9,10 DIHYDROACRIDINE 4 CARBONYL)AMINO]ETHYL] N,N' DIMETHYLETHYLENEDIAMINE;
N,N' BIS[2 [(1 NITRO 9 OXO 9,10 DIHYDROACRIDINE 4 CARBONYL)AMINO]ETHYL] N,N' DIMETHYLPROPYLENEDIAMINE;
N,N' BIS[2 [(9 OXO 9,10 DIHYDROACRIDINE 4 CARBONYL)AMINO]ETHYL] N,N' DIMETHYLPROPYLENEDIAMINE;
PLASMID DNA;
UNCLASSIFIED DRUG;
ANIMAL CELL;
ANTINEOPLASTIC ACTIVITY;
ARTICLE;
BINDING ASSAY;
BINDING COMPETITION;
CANCER CELL CULTURE;
CELL STRAIN HT29;
CHROMATOPHORE;
CONFORMATIONAL TRANSITION;
CONTROLLED STUDY;
CYTOTOXICITY TEST;
DNA DRUG COMPLEX;
DNA HELIX;
DNA SUPERCOILING;
DRUG ACTIVITY;
DRUG CONFORMATION;
DRUG DNA BINDING;
DRUG POTENCY;
DRUG RESISTANCE;
DRUG SENSITIVITY;
DRUG SYNTHESIS;
HUMAN;
HUMAN CELL;
INTERCALATION COMPLEX;
MOLECULAR DYNAMICS;
MOLECULAR MODEL;
MOUSE;
NONHUMAN;
PREDICTION;
ACRIDINES;
AMINES;
ANTINEOPLASTIC AGENTS;
BINDING SITES;
CISPLATIN;
DNA, SUPERHELICAL;
DRUG RESISTANCE, NEOPLASM;
DRUG SCREENING ASSAYS, ANTITUMOR;
HUMANS;
INHIBITORY CONCENTRATION 50;
INTERCALATING AGENTS;
LIGANDS;
MODELS, MOLECULAR;
OLIGONUCLEOTIDES;
STRUCTURE-ACTIVITY RELATIONSHIP;
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EID: 0037023565
PISSN: 02235234
EISSN: None
Source Type: Journal
DOI: 10.1016/S0223-5234(02)01348-X Document Type: Article |
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Times cited : (19)
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References (43)
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